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Search results 1 to 100 out of 1243 for Uchl1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Domain
Type: Family
Description: Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinase that has dual hydrolase and ligase activities []. It is the most abundant protein in brain lysates (1-2%), regulating the timing and the pattern of ubiquitination []. Mutations in the UCHL1 gene has been linked to neurodegenerative diseases [, ]. UCHL1 also pays a major role in oncogenesis [].
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Allele
Name: transgene insertion NO63, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication
First Author: Jara JH
Year: 2013
Journal: Cell Biochem Biophys
Title: Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.
Volume: 67
Issue: 1
Pages: 45-53
Publication
First Author: Setsuie R
Year: 2007
Journal: Neurochem Int
Title: The functions of UCH-L1 and its relation to neurodegenerative diseases.
Volume: 51
Issue: 2-4
Pages: 105-11
Publication
First Author: Proctor CJ
Year: 2010
Journal: PLoS One
Title: Modelling the role of UCH-L1 on protein aggregation in age-related neurodegeneration.
Volume: 5
Issue: 10
Pages: e13175
Strain
Attribute String: transgenic, mutant stock
Publication
First Author: Gao H
Year: 2020
Journal: PLoS One
Title: UCHL1 regulates oxidative activity in skeletal muscle.
Volume: 15
Issue: 11
Pages: e0241716
Publication
First Author: Fuchs EC
Year: 2016
Journal: Neuron
Title: Local and Distant Input Controlling Excitation in Layer II of the Medial Entorhinal Cortex.
Volume: 89
Issue: 1
Pages: 194-208
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
Protein
Organism: Mus musculus
Length: 223  
Fragment?: false
Protein
Organism: Mus musculus
Length: 147  
Fragment?: true
Protein
Organism: Mus musculus
Length: 225  
Fragment?: true
Publication  
First Author: Gao H
Year: 2019
Journal: Life Sci
Title: UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle.
Volume: 233
Pages: 116699
Publication
First Author: Carrieri C
Year: 2012
Journal: Nature
Title: Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.
Volume: 491
Issue: 7424
Pages: 454-7
Publication  
First Author: Coulombe J
Year: 2014
Journal: Front Aging Neurosci
Title: Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system.
Volume: 6
Pages: 129
Publication      
First Author: Liu H
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Publication
First Author: Jara JH
Year: 2015
Journal: Cereb Cortex
Title: Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function.
Volume: 25
Issue: 11
Pages: 4259-72
Publication      
First Author: Karst SY
Year: 2010
Journal: MGI Direct Data Submission
Title: Gracile axonal dystrophy 2 Jackson; a neuromuscular mutation in the Uchl1 gene
Publication
First Author: Setsuie R
Year: 2007
Journal: Neurochem Int
Title: Dopaminergic neuronal loss in transgenic mice expressing the Parkinson's disease-associated UCH-L1 I93M mutant.
Volume: 50
Issue: 1
Pages: 119-29
Publication
First Author: Yasuda T
Year: 2009
Journal: J Neurochem
Title: Effects of UCH-L1 on alpha-synuclein over-expression mouse model of Parkinson's disease.
Volume: 108
Issue: 4
Pages: 932-44
Publication
First Author: Wiese CB
Year: 2013
Journal: Genesis
Title: A Uchl1-Histone2BmCherry:GFP-gpi BAC transgene for imaging neuronal progenitors.
Volume: 51
Issue: 12
Pages: 852-61
Publication
First Author: Wang Y
Year: 2000
Journal: Genomics
Title: YAC/BAC-based physical and transcript mapping around the gracile axonal dystrophy (gad) locus identifies Uchl1, Pmx2b, Atp3a2, and Hip2 genes.
Volume: 66
Issue: 3
Pages: 333-6
Publication
First Author: Read NC
Year: 2014
Journal: Biochim Biophys Acta
Title: Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis.
Volume: 1842
Issue: 7
Pages: 1028-40
Publication
First Author: Koyanagi S
Year: 2012
Journal: Reproduction
Title: Effects of ubiquitin C-terminal hydrolase L1 deficiency on mouse ova.
Volume: 143
Issue: 3
Pages: 271-9
Publication
First Author: Zhang M
Year: 2012
Journal: J Neurochem
Title: Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1.
Volume: 120
Issue: 6
Pages: 1129-38
Publication
First Author: Lei Q
Year: 2020
Journal: Sci Rep
Title: Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Volume: 10
Issue: 1
Pages: 10604
Publication
First Author: Chu KY
Year: 2012
Journal: Diabetologia
Title: Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions.
Volume: 55
Issue: 1
Pages: 128-40
Publication
First Author: Hussain S
Year: 2018
Journal: Blood
Title: UCH-L1 bypasses mTOR to promote protein biosynthesis and is required for MYC-driven lymphomagenesis in mice.
Volume: 132
Issue: 24
Pages: 2564-2574
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Saigoh K
Year: 1999
Journal: Nat Genet
Title: Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice.
Volume: 23
Issue: 1
Pages: 47-51
Publication
First Author: Marzban G
Year: 2002
Journal: Exp Gerontol
Title: Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries.
Volume: 37
Issue: 12
Pages: 1451-60
Publication
First Author: Harada T
Year: 2004
Journal: Am J Pathol
Title: Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo.
Volume: 164
Issue: 1
Pages: 59-64
Publication
First Author: Sakurai M
Year: 2008
Journal: Eur J Neurosci
Title: Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene.
Volume: 27
Issue: 3
Pages: 691-701
Publication
First Author: Cartier AE
Year: 2009
Journal: J Neurosci
Title: Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1.
Volume: 29
Issue: 24
Pages: 7857-68
Publication
First Author: Yamazaki K
Year: 1988
Journal: Proc Soc Exp Biol Med
Title: Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse.
Volume: 187
Issue: 2
Pages: 209-15
Publication
First Author: Yamazaki K
Year: 1993
Journal: Mol Chem Neuropathol
Title: Substance P-immunoreactive astrocytes in gracile sensory nervous tract of spinal cord in gracile axonal dystrophy mutant mouse.
Volume: 20
Issue: 1
Pages: 1-20
Publication
First Author: Yamazaki K
Year: 1992
Journal: Jikken Dobutsu
Title: Behavioral study on the gracile axonal dystrophy (GAD) mutant mouse.
Volume: 41
Issue: 4
Pages: 523-7
Publication
First Author: Pfeffer M
Year: 2012
Journal: Neurobiol Aging
Title: Disturbed sleep/wake rhythms and neuronal cell loss in lateral hypothalamus and retina of mice with a spontaneous deletion in the ubiquitin carboxyl-terminal hydrolase L1 gene.
Volume: 33
Issue: 2
Pages: 393-403
Publication
First Author: Takagi A
Year: 1996
Journal: Virchows Arch
Title: Fine structural changes of muscle spindles in the gracile axonal dystrophy mutant mouse.
Volume: 428
Issue: 4-5
Pages: 289-96
Publication
First Author: Miura H
Year: 1993
Journal: Neuropathol Appl Neurobiol
Title: Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy.
Volume: 19
Issue: 1
Pages: 41-51
Publication
First Author: Yamazaki K
Year: 1994
Journal: Neurosci Lett
Title: Methylcobalamin (methyl-B12) promotes regeneration of motor nerve terminals degenerating in anterior gracile muscle of gracile axonal dystrophy (GAD) mutant mouse.
Volume: 170
Issue: 1
Pages: 195-7
Publication
First Author: Suh JG
Year: 1994
Journal: Biomed Res
Title: Pathophysiological study of axonal degeneration in the gracile axonal dystrophy (gad) mutant mouse.
Volume: 15
Issue: 4
Pages: 241-246
Publication
First Author: Chandran AP
Year: 1995
Journal: Electromyogr Clin Neurophysiol
Title: Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse.
Volume: 35
Issue: 4
Pages: 225-30
Publication
First Author: Mukoyama M
Year: 1989
Journal: Acta Neuropathol
Title: Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons.
Volume: 79
Issue: 3
Pages: 294-9
Publication
First Author: Wang YL
Year: 2006
Journal: Mol Reprod Dev
Title: Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice.
Volume: 73
Issue: 1
Pages: 40-9
Publication
First Author: Xilouri M
Year: 2012
Journal: Hum Mol Genet
Title: Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system.
Volume: 21
Issue: 4
Pages: 874-89
Publication
First Author: Bedekovics T
Year: 2016
Journal: Blood
Title: UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma.
Volume: 127
Issue: 12
Pages: 1564-74
Publication
First Author: Chen F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.
Volume: 107
Issue: 4
Pages: 1636-41
Publication
First Author: Li JC
Year: 2000
Journal: World J Gastroenterol
Title: Immunohistochemical study on gastroenteric nervous system in trisomy 16 mice:an animal model of Down syndrome.
Volume: 6
Issue: 6
Pages: 793-799
Publication
First Author: Schofield JN
Year: 1995
Journal: Brain Res Dev Brain Res
Title: PGP9.5, a ubiquitin C-terminal hydrolase; pattern of mRNA and protein expression during neural development in the mouse.
Volume: 85
Issue: 2
Pages: 229-38
Publication
First Author: Suh JG
Year: 1995
Journal: Genomics
Title: Mapping of the gracile axonal dystrophy (gad) gene to a region between D5Mit197 and D5Mit113 on proximal mouse chromosome 5.
Volume: 27
Issue: 3
Pages: 549-51
Publication
First Author: Sekiguchi S
Year: 2003
Journal: Exp Anim
Title: Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse.
Volume: 52
Issue: 4
Pages: 365-9
Publication
First Author: Li JC
Year: 2001
Journal: World J Gastroenterol
Title: The development of colon innervation in trisomy 16 mice and Hirschsprung's disease.
Volume: 7
Issue: 1
Pages: 16-21
Publication
First Author: Lohmann F
Year: 2014
Journal: Biochim Biophys Acta
Title: UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.
Volume: 1842
Issue: 7
Pages: 945-58
Publication
First Author: Reinicke AT
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitin C-terminal hydrolase L1 (UCH-L1) loss causes neurodegeneration by altering protein turnover in the first postnatal weeks.
Volume: 116
Issue: 16
Pages: 7963-7972
Publication
First Author: Radón V
Year: 2018
Journal: Kidney Int
Title: Ubiquitin C-Terminal Hydrolase L1 is required for regulated protein degradation through the ubiquitin proteasome system in kidney.
Volume: 93
Issue: 1
Pages: 110-127
Publication
First Author: Reinicke AT
Year: 2019
Journal: J Immunol
Title: Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules.
Volume: 203
Issue: 7
Pages: 1730-1742
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 14
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 8
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3267828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 5
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1755028
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3519728
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 30
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1925228
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 29
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3552328
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: false
Specimen Num: 17
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 20
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 11
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: false
Specimen Num: 25
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 10
GXD Expression      
Probe: MGI:3804413
Assay Type: RT-PCR
Annotation Date: 2008-09-05
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3804645
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3283428
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 28
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 23
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3276028
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: false
Specimen Num: 18
GXD Expression      
Probe: MGI:3625129
Assay Type: RT-PCR
Annotation Date: 2006-06-22
Strength: Present
Sex: Male
Emaps: EMAPS:2979428
Stage: TS28
Assay Id: MGI:3625133
Age: postnatal
Detected: true
Specimen Num: 34