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Search results 1 to 100 out of 1089 for Ucp1

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Type Details Score
Gene
key_980140 | Ucp1
Type: gene
Organism: Not Specified
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Gene
7350 | UCP1
Type: gene
Organism: human
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Gene
281561 | UCP1
Type: gene
Organism: cattle
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Gene
83908 | ucp1
Type: gene
Organism: zebrafish
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Gene
574124 | UCP1
Type: gene
Organism: macaque, rhesus
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Gene
100135179 | ucp1
Type: gene
Organism: frog, western clawed
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Gene
24860 | Ucp1
Type: gene
Organism: rat
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Gene
403574 | UCP1
Type: gene
Organism: dog, domestic
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Gene
461504 | UCP1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR040011 | UCP1
Type: Family
Description: Uncoupling protein 1 (UCP1) is mainly expressed in brown adipose tissue, and acts in thermogenesis, regulation of energy expenditure, and protection against oxidative stress. Despite being a member of the family of mitochondrial anion carriers, UCP1 is a H(+) carrier activated by long-chain fatty acids []. It is activated by fatty acids and inhibited by purine nucleotides []. UCP1 catalyzes proton leakage across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is a candidate gene for the development of obesity and type 2 diabetes mellitus [].
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Protein Coding Gene
MGI:98894 | Ucp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23063128 | J:189069
First Author: Fedorenko A
Year: 2012
Journal: Cell
Title: Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.
Volume: 151
Issue: 2
Pages: 400-13
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Publication
22952235 | J:236213
First Author: Divakaruni AS
Year: 2012
Journal: J Biol Chem
Title: Fatty acids change the conformation of uncoupling protein 1 (UCP1).
Volume: 287
Issue: 44
Pages: 36845-53
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Publication
22790465 | -
First Author: Brondani LA
Year: 2012
Journal: Arq Bras Endocrinol Metabol
Title: The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus.
Volume: 56
Issue: 4
Pages: 215-25
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Protein
P12242
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Publication
34861155 | J:321712
First Author: Mills EL
Year: 2022
Journal: Cell Metab
Title: Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Volume: 34
Issue: 1
Pages: 140-157.e8
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Publication
10050760 | J:53082
First Author: Baumruk F
Year: 1999
Journal: FEBS Lett
Title: Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential.
Volume: 444
Issue: 2-3
Pages: 206-10
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Publication
31918922 | J:299340
 
First Author: Johnson JM
Year: 2020
Journal: Mol Metab
Title: Alternative splicing of UCP1 by non-cell-autonomous action of PEMT.
Volume: 31
Pages: 55-66
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Publication
12746468 | J:83834
First Author: Coulter AA
Year: 2003
Journal: Physiol Genomics
Title: Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat.
Volume: 14
Issue: 2
Pages: 139-47
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Publication
16595854 | J:111348
First Author: Golozoubova V
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: UCP1 is essential for adaptive adrenergic nonshivering thermogenesis.
Volume: 291
Issue: 2
Pages: E350-7
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Publication
38272036 | J:345951
First Author: Rahbani JF
Year: 2024
Journal: Cell Metab
Title: Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Volume: 36
Issue: 3
Pages: 526-540.e7
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Publication
24290753 | J:206840
First Author: Shabalina IG
Year: 2013
Journal: Cell Rep
Title: UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.
Volume: 5
Issue: 5
Pages: 1196-203
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Publication
15924571 | J:292570
First Author: Kontani Y
Year: 2005
Journal: Aging Cell
Title: UCP1 deficiency increases susceptibility to diet-induced obesity with age.
Volume: 4
Issue: 3
Pages: 147-55
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Publication
34129966 | J:310472
 
First Author: Fujita H
Year: 2021
Journal: Biochem Biophys Res Commun
Title: UCP1 expression in the mouse adrenal gland is not upregulated by thermogenic conditions.
Volume: 566
Pages: 184-189
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Publication
27264172 | J:238159
First Author: Sambeat A
Year: 2016
Journal: Cell Rep
Title: LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
Volume: 15
Issue: 11
Pages: 2536-49
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Publication
32184391 | J:286400
First Author: Shamsi F
Year: 2020
Journal: Nat Commun
Title: FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis.
Volume: 11
Issue: 1
Pages: 1421
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Publication
35236897 | J:321669
First Author: Saijo S
Year: 2022
Journal: Sci Rep
Title: Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
Volume: 12
Issue: 1
Pages: 3449
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Publication
31000437 | J:275689
First Author: Wang G
Year: 2019
Journal: Mol Cell
Title: Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Volume: 74
Issue: 4
Pages: 844-857.e7
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Publication
23757405 | J:203201
First Author: Adjeitey CN
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production.
Volume: 305
Issue: 3
Pages: E405-15
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Publication
33107819 | J:298568
   
First Author: Yi D
Year: 2020
Journal: Elife
Title: Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes.
Volume: 9
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Publication
28696252 | J:267233
First Author: Williams JW
Year: 2017
Journal: Circ Res
Title: Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood.
Volume: 121
Issue: 6
Pages: 662-676
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Publication
20238096 | J:159866
First Author: Shore A
Year: 2010
Journal: Diabetologia
Title: Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue.
Volume: 53
Issue: 6
Pages: 1164-73
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Publication
27508873 | J:251871
First Author: Porter C
Year: 2016
Journal: Cell Metab
Title: Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function.
Volume: 24
Issue: 2
Pages: 246-55
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Publication
19958747 | J:164820
First Author: Keipert S
Year: 2010
Journal: Biochim Biophys Acta
Title: UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production.
Volume: 1797
Issue: 2
Pages: 324-30
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Publication
25578880 | J:218161
First Author: Dempersmier J
Year: 2015
Journal: Mol Cell
Title: Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
Volume: 57
Issue: 2
Pages: 235-46
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Publication
30348622 | J:278923
 
First Author: Qiu Y
Year: 2018
Journal: EBioMedicine
Title: Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue.
Volume: 37
Pages: 344-355
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Publication
28630339 | J:244963
First Author: Kazak L
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
Volume: 114
Issue: 30
Pages: 7981-7986
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Publication
37125774 | J:335532
     
First Author: Som R
Year: 2023
Journal: Am J Physiol Cell Physiol
Title: Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression.
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Publication
16543238 | J:113503
First Author: Shabalina IG
Year: 2006
Journal: J Biol Chem
Title: UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent.
Volume: 281
Issue: 20
Pages: 13882-93
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Publication
17164436 | J:120398
First Author: Okamatsu-Ogura Y
Year: 2007
Journal: Am J Physiol Endocrinol Metab
Title: Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice.
Volume: 292
Issue: 4
Pages: E1135-9
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Publication
15208325 | J:92814
First Author: Shabalina IG
Year: 2004
Journal: J Biol Chem
Title: Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids.
Volume: 279
Issue: 37
Pages: 38236-48
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Publication
25605929 | J:217660
First Author: Laursen WJ
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.
Volume: 112
Issue: 5
Pages: 1607-12
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Publication
17972916 | J:128906
First Author: Kiskinis E
Year: 2007
Journal: EMBO J
Title: RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes.
Volume: 26
Issue: 23
Pages: 4831-40
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Publication
29890133 | J:270593
First Author: Jung S
Year: 2018
Journal: Biochem Biophys Res Commun
Title: HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression.
Volume: 503
Issue: 1
Pages: 285-290
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Publication
16368788 | J:108376
First Author: Inokuma K
Year: 2006
Journal: Am J Physiol Endocrinol Metab
Title: Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation.
Volume: 290
Issue: 5
Pages: E1014-21
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Publication
29203476 | J:257465
First Author: Bond LM
Year: 2018
Journal: J Lipid Res
Title: UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver.
Volume: 59
Issue: 2
Pages: 224-236
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Publication
29212043 | J:333169
First Author: Macher G
Year: 2018
Journal: Biochim Biophys Acta Biomembr
Title: Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.
Volume: 1860
Issue: 3
Pages: 664-672
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Publication
30177570 | J:266624
 
First Author: Chen HF
Year: 2018
Journal: EMBO J
Title: CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue.
Volume: 37
Issue: 20
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Publication
16135818 | J:101371
First Author: Xue B
Year: 2005
Journal: Mol Cell Biol
Title: Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots.
Volume: 25
Issue: 18
Pages: 8311-22
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Publication
24416310 | J:212205
First Author: Knudsen JG
Year: 2014
Journal: PLoS One
Title: Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue.
Volume: 9
Issue: 1
Pages: e84910
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Publication
19187776 | J:146646
First Author: Feldmann HM
Year: 2009
Journal: Cell Metab
Title: UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.
Volume: 9
Issue: 2
Pages: 203-9
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Publication
26518386 | J:250632
First Author: Hilse KE
Year: 2016
Journal: Biochim Biophys Acta
Title: The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue.
Volume: 1857
Issue: 1
Pages: 72-78
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Publication
26884382 | J:237316
First Author: Sakamoto T
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice.
Volume: 310
Issue: 8
Pages: E676-E687
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Publication
23717545 | J:200834
First Author: Ringholm S
Year: 2013
Journal: PLoS One
Title: PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue.
Volume: 8
Issue: 5
Pages: e64123
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Publication
25863250 | J:271356
First Author: Dai N
Year: 2015
Journal: Cell Metab
Title: IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins.
Volume: 21
Issue: 4
Pages: 609-21
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Publication
38325495 | J:345694
 
First Author: Stanic S
Year: 2024
Journal: Biochem Pharmacol
Title: Prolonged FGF21 treatment increases energy expenditure and induces weight loss in obese mice independently of UCP1 and adrenergic signaling.
Volume: 221
Pages: 116042
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Publication
37240054 | J:336168
 
First Author: Zu Y
Year: 2023
Journal: Int J Mol Sci
Title: Temperature-Dependent Effects of Eicosapentaenoic Acid (EPA) on Browning of Subcutaneous Adipose Tissue in UCP1 Knockout Male Mice.
Volume: 24
Issue: 10
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Publication
25742717 | J:223358
First Author: Wanders D
Year: 2015
Journal: FASEB J
Title: UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity.
Volume: 29
Issue: 6
Pages: 2603-15
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Publication
- | J:148827
     
First Author: Moir L
Year: 2009
Journal: MGI Direct Data Submission
Title: TRI is an allele of Ucp1 and results in thermoregulation defects: Record for Ucp11H
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Publication
18678870 | J:142314
First Author: Anunciado-Koza R
Year: 2008
Journal: J Biol Chem
Title: Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity.
Volume: 283
Issue: 41
Pages: 27688-97
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Publication
27881400 | J:246770
First Author: Winn NC
Year: 2017
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice.
Volume: 312
Issue: 1
Pages: R74-R84
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Publication
22676960 | J:188064
First Author: Jastroch M
Year: 2012
Journal: Biochim Biophys Acta
Title: Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak.
Volume: 1817
Issue: 9
Pages: 1660-70
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Publication
10497167 | J:57998
First Author: Matthias A
Year: 1999
Journal: J Biol Chem
Title: The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling").
Volume: 274
Issue: 40
Pages: 28150-60
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Publication
32715748 | J:296858
First Author: Botezelli JD
Year: 2020
Journal: Am J Physiol Endocrinol Metab
Title: Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice.
Volume: 319
Issue: 3
Pages: E529-E539
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Publication
32179129 | J:293988
First Author: Kataoka N
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice.
Volume: 1866
Issue: 7
Pages: 165762
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Publication
15036332 | J:102003
First Author: Blanco G
Year: 2004
Journal: Neuromuscul Disord
Title: Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle.
Volume: 14
Issue: 3
Pages: 217-28
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Publication
26841864 | J:232728
First Author: Schneider K
Year: 2016
Journal: J Biol Chem
Title: Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2).
Volume: 291
Issue: 14
Pages: 7754-66
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Publication
28655717 | J:262153
First Author: Winn NC
Year: 2017
Journal: Am J Physiol Endocrinol Metab
Title: Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction.
Volume: 313
Issue: 4
Pages: E402-E412
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Publication
16876797 | J:112155
First Author: Lehr L
Year: 2006
Journal: FEBS Lett
Title: The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture.
Volume: 580
Issue: 19
Pages: 4661-6
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Publication
15964803 | J:99123
First Author: Robidoux J
Year: 2005
Journal: Mol Cell Biol
Title: Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Volume: 25
Issue: 13
Pages: 5466-79
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Publication
32245957 | J:287107
First Author: Wang Y
Year: 2020
Journal: Nat Commun
Title: METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice.
Volume: 11
Issue: 1
Pages: 1648
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Publication
12221093 | J:80053
First Author: Couplan E
Year: 2002
Journal: J Biol Chem
Title: High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content.
Volume: 277
Issue: 45
Pages: 43079-88
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Allele
Ucp1<em1Etch> | MGI:6888035
 
Name: uncoupling protein 1 (mitochondrial, proton carrier); endonuclease-mediated mutation 1, Edward T Chouchani
Allele Type: Endonuclease-mediated
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Publication
26055106 | J:256980
 
First Author: Nguyen AD
Year: 2018
Journal: Bone
Title: Uncoupling protein-1 is protective of bone mass under mild cold stress conditions.
Volume: 106
Pages: 167-178
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Publication
14613927 | J:95413
First Author: Han DH
Year: 2004
Journal: Am J Physiol Endocrinol Metab
Title: UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction.
Volume: 286
Issue: 3
Pages: E347-53
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Publication
11017142 | J:65242
First Author: Li B
Year: 2000
Journal: Nat Med
Title: Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice.
Volume: 6
Issue: 10
Pages: 1115-20
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Publication
19404401 | J:148251
First Author: Dupuis L
Year: 2009
Journal: PLoS One
Title: Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons.
Volume: 4
Issue: 4
Pages: e5390
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Publication
28614293 | J:249650
First Author: Emmett MJ
Year: 2017
Journal: Nature
Title: Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge.
Volume: 546
Issue: 7659
Pages: 544-548
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Publication
24129192 | J:211525
First Author: Nakamura Y
Year: 2013
Journal: Biochem Biophys Res Commun
Title: FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1.
Volume: 441
Issue: 1
Pages: 42-6
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Publication
- | J:337787
First Author: Wang Y
Year: 2022
Journal: Life Metabolism
Title: WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice.
Volume: 1
Issue: 3
Pages: 270-284
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Publication
20466728 | J:165318
First Author: Oelkrug R
Year: 2010
Journal: J Biol Chem
Title: Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.
Volume: 285
Issue: 29
Pages: 21961-8
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Publication
25135951 | J:217556
First Author: Li Y
Year: 2014
Journal: EMBO Rep
Title: Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes.
Volume: 15
Issue: 10
Pages: 1069-76
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Publication
18489899 | J:136945
First Author: Shabalina IG
Year: 2008
Journal: Biochim Biophys Acta
Title: Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism.
Volume: 1777
Issue: 7-8
Pages: 642-50
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Publication
28380374 | J:251864
First Author: Bertholet AM
Year: 2017
Journal: Cell Metab
Title: Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.
Volume: 25
Issue: 4
Pages: 811-822.e4
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Publication
30184507 | J:268416
First Author: Hagberg CE
Year: 2018
Journal: Cell Rep
Title: Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity.
Volume: 24
Issue: 10
Pages: 2746-2756.e5
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Publication
31619741 | J:285500
First Author: Antonacci MA
Year: 2019
Journal: Sci Rep
Title: Direct detection of brown adipose tissue thermogenesis in UCP1-/- mice by hyperpolarized 129Xe MR thermometry.
Volume: 9
Issue: 1
Pages: 14865
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Publication
25955208 | J:225847
First Author: Véniant MM
Year: 2015
Journal: Cell Metab
Title: Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.
Volume: 21
Issue: 5
Pages: 731-8
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Publication
26586424 | J:228947
First Author: Kwon MM
Year: 2015
Journal: Cell Rep
Title: FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1.
Volume: 13
Issue: 8
Pages: 1521-7
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Publication
31067456 | J:280553
First Author: Luijten IHN
Year: 2019
Journal: Cell Rep
Title: Glucocorticoid-Induced Obesity Develops Independently of UCP1.
Volume: 27
Issue: 6
Pages: 1686-1698.e5
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Publication
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