Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
Not Specified |
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•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Uncoupling protein 1 (UCP1) is mainly expressed in brown adipose tissue, and acts in thermogenesis, regulation of energy expenditure, and protection against oxidative stress. Despite being a member of the family of mitochondrial anion carriers, UCP1 is a H(+) carrier activated by long-chain fatty acids []. It is activated by fatty acids and inhibited by purine nucleotides []. UCP1 catalyzes proton leakage across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is a candidate gene for the development of obesity and type 2 diabetes mellitus []. |
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•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Fedorenko A |
Year: |
2012 |
Journal: |
Cell |
Title: |
Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. |
Volume: |
151 |
Issue: |
2 |
Pages: |
400-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Divakaruni AS |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Fatty acids change the conformation of uncoupling protein 1 (UCP1). |
Volume: |
287 |
Issue: |
44 |
Pages: |
36845-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brondani LA |
Year: |
2012 |
Journal: |
Arq Bras Endocrinol Metabol |
Title: |
The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus. |
Volume: |
56 |
Issue: |
4 |
Pages: |
215-25 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
307
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Mills EL |
Year: |
2022 |
Journal: |
Cell Metab |
Title: |
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. |
Volume: |
34 |
Issue: |
1 |
Pages: |
140-157.e8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baumruk F |
Year: |
1999 |
Journal: |
FEBS Lett |
Title: |
Transgenic UCP1 in white adipocytes modulates mitochondrial membrane potential. |
Volume: |
444 |
Issue: |
2-3 |
Pages: |
206-10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Johnson JM |
Year: |
2020 |
Journal: |
Mol Metab |
Title: |
Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. |
Volume: |
31 |
|
Pages: |
55-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Golozoubova V |
Year: |
2006 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. |
Volume: |
291 |
Issue: |
2 |
Pages: |
E350-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Coulter AA |
Year: |
2003 |
Journal: |
Physiol Genomics |
Title: |
Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat. |
Volume: |
14 |
Issue: |
2 |
Pages: |
139-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rahbani JF |
Year: |
2024 |
Journal: |
Cell Metab |
Title: |
Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB. |
Volume: |
36 |
Issue: |
3 |
Pages: |
526-540.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kontani Y |
Year: |
2005 |
Journal: |
Aging Cell |
Title: |
UCP1 deficiency increases susceptibility to diet-induced obesity with age. |
Volume: |
4 |
Issue: |
3 |
Pages: |
147-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shabalina IG |
Year: |
2013 |
Journal: |
Cell Rep |
Title: |
UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. |
Volume: |
5 |
Issue: |
5 |
Pages: |
1196-203 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujita H |
Year: |
2021 |
Journal: |
Biochem Biophys Res Commun |
Title: |
UCP1 expression in the mouse adrenal gland is not upregulated by thermogenic conditions. |
Volume: |
566 |
|
Pages: |
184-189 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sambeat A |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program. |
Volume: |
15 |
Issue: |
11 |
Pages: |
2536-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shamsi F |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1421 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saijo S |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. |
Volume: |
12 |
Issue: |
1 |
Pages: |
3449 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang G |
Year: |
2019 |
Journal: |
Mol Cell |
Title: |
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation. |
Volume: |
74 |
Issue: |
4 |
Pages: |
844-857.e7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adjeitey CN |
Year: |
2013 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production. |
Volume: |
305 |
Issue: |
3 |
Pages: |
E405-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yi D |
Year: |
2020 |
Journal: |
Elife |
Title: |
Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Williams JW |
Year: |
2017 |
Journal: |
Circ Res |
Title: |
Thermoneutrality but Not UCP1 Deficiency Suppresses Monocyte Mobilization Into Blood. |
Volume: |
121 |
Issue: |
6 |
Pages: |
662-676 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shore A |
Year: |
2010 |
Journal: |
Diabetologia |
Title: |
Role of Ucp1 enhancer methylation and chromatin remodelling in the control of Ucp1 expression in murine adipose tissue. |
Volume: |
53 |
Issue: |
6 |
Pages: |
1164-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Porter C |
Year: |
2016 |
Journal: |
Cell Metab |
Title: |
Human and Mouse Brown Adipose Tissue Mitochondria Have Comparable UCP1 Function. |
Volume: |
24 |
Issue: |
2 |
Pages: |
246-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Keipert S |
Year: |
2010 |
Journal: |
Biochim Biophys Acta |
Title: |
UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. |
Volume: |
1797 |
Issue: |
2 |
Pages: |
324-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dempersmier J |
Year: |
2015 |
Journal: |
Mol Cell |
Title: |
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat. |
Volume: |
57 |
Issue: |
2 |
Pages: |
235-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shabalina IG |
Year: |
2006 |
Journal: |
J Biol Chem |
Title: |
UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent. |
Volume: |
281 |
Issue: |
20 |
Pages: |
13882-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Okamatsu-Ogura Y |
Year: |
2007 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Brown fat UCP1 is not involved in the febrile and thermogenic responses to IL-1beta in mice. |
Volume: |
292 |
Issue: |
4 |
Pages: |
E1135-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shabalina IG |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. |
Volume: |
279 |
Issue: |
37 |
Pages: |
38236-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Som R |
Year: |
2023 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kazak L |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. |
Volume: |
114 |
Issue: |
30 |
Pages: |
7981-7986 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiu Y |
Year: |
2018 |
Journal: |
EBioMedicine |
Title: |
Screening of FDA-approved drugs identifies sutent as a modulator of UCP1 expression in brown adipose tissue. |
Volume: |
37 |
|
Pages: |
344-355 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gu M |
Year: |
2024 |
Journal: |
Cell Death Dis |
Title: |
Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis. |
Volume: |
15 |
Issue: |
7 |
Pages: |
518 |
|
•
•
•
•
•
|
Publication |
First Author: |
Laursen WJ |
Year: |
2015 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation. |
Volume: |
112 |
Issue: |
5 |
Pages: |
1607-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kiskinis E |
Year: |
2007 |
Journal: |
EMBO J |
Title: |
RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. |
Volume: |
26 |
Issue: |
23 |
Pages: |
4831-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung S |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
HDAC6 regulates thermogenesis of brown adipocytes through activating PKA to induce UCP1 expression. |
Volume: |
503 |
Issue: |
1 |
Pages: |
285-290 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inokuma K |
Year: |
2006 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. |
Volume: |
290 |
Issue: |
5 |
Pages: |
E1014-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bond LM |
Year: |
2018 |
Journal: |
J Lipid Res |
Title: |
UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver. |
Volume: |
59 |
Issue: |
2 |
Pages: |
224-236 |
|
•
•
•
•
•
|
Publication |
First Author: |
Macher G |
Year: |
2018 |
Journal: |
Biochim Biophys Acta Biomembr |
Title: |
Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. |
Volume: |
1860 |
Issue: |
3 |
Pages: |
664-672 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen HF |
Year: |
2018 |
Journal: |
EMBO J |
Title: |
CPEB2-dependent translation of long 3'-UTR Ucp1 mRNA promotes thermogenesis in brown adipose tissue. |
Volume: |
37 |
Issue: |
20 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Knudsen JG |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e84910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xue B |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. |
Volume: |
25 |
Issue: |
18 |
Pages: |
8311-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feldmann HM |
Year: |
2009 |
Journal: |
Cell Metab |
Title: |
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. |
Volume: |
9 |
Issue: |
2 |
Pages: |
203-9 |
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•
•
•
•
•
|
Publication |
First Author: |
Hilse KE |
Year: |
2016 |
Journal: |
Biochim Biophys Acta |
Title: |
The expression of UCP3 directly correlates to UCP1 abundance in brown adipose tissue. |
Volume: |
1857 |
Issue: |
1 |
Pages: |
72-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sakamoto T |
Year: |
2016 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice. |
Volume: |
310 |
Issue: |
8 |
Pages: |
E676-E687 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ringholm S |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e64123 |
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•
•
•
•
•
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Publication |
First Author: |
Dai N |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. |
Volume: |
21 |
Issue: |
4 |
Pages: |
609-21 |
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•
•
•
•
•
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Publication |
First Author: |
Wanders D |
Year: |
2015 |
Journal: |
FASEB J |
Title: |
UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity. |
Volume: |
29 |
Issue: |
6 |
Pages: |
2603-15 |
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•
•
•
•
•
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Publication |
First Author: |
Zu Y |
Year: |
2023 |
Journal: |
Int J Mol Sci |
Title: |
Temperature-Dependent Effects of Eicosapentaenoic Acid (EPA) on Browning of Subcutaneous Adipose Tissue in UCP1 Knockout Male Mice. |
Volume: |
24 |
Issue: |
10 |
|
|
•
•
•
•
•
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Publication |
First Author: |
Stanic S |
Year: |
2024 |
Journal: |
Biochem Pharmacol |
Title: |
Prolonged FGF21 treatment increases energy expenditure and induces weight loss in obese mice independently of UCP1 and adrenergic signaling. |
Volume: |
221 |
|
Pages: |
116042 |
|
•
•
•
•
•
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Publication |
First Author: |
Masania J |
Year: |
2023 |
Journal: |
Redox Biol |
Title: |
Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle. |
Volume: |
59 |
|
Pages: |
102574 |
|
•
•
•
•
•
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Publication |
First Author: |
Moir L |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
TRI is an allele of Ucp1 and results in thermoregulation defects: Record for Ucp11H |
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|
|
|
•
•
•
•
•
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Publication |
First Author: |
Anunciado-Koza R |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Inactivation of UCP1 and the glycerol phosphate cycle synergistically increases energy expenditure to resist diet-induced obesity. |
Volume: |
283 |
Issue: |
41 |
Pages: |
27688-97 |
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•
•
•
•
•
|
Publication |
First Author: |
Winn NC |
Year: |
2017 |
Journal: |
Am J Physiol Regul Integr Comp Physiol |
Title: |
Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice. |
Volume: |
312 |
Issue: |
1 |
Pages: |
R74-R84 |
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•
•
•
•
•
|
Publication |
First Author: |
Jastroch M |
Year: |
2012 |
Journal: |
Biochim Biophys Acta |
Title: |
Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak. |
Volume: |
1817 |
Issue: |
9 |
Pages: |
1660-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Matthias A |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling"). |
Volume: |
274 |
Issue: |
40 |
Pages: |
28150-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Botezelli JD |
Year: |
2020 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Adipose depot-specific upregulation of Ucp1 or mitochondrial oxidative complex proteins are early consequences of genetic insulin reduction in mice. |
Volume: |
319 |
Issue: |
3 |
Pages: |
E529-E539 |
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•
•
•
•
•
|
Publication |
First Author: |
Kataoka N |
Year: |
2020 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. |
Volume: |
1866 |
Issue: |
7 |
Pages: |
165762 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blanco G |
Year: |
2004 |
Journal: |
Neuromuscul Disord |
Title: |
Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle. |
Volume: |
14 |
Issue: |
3 |
Pages: |
217-28 |
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•
•
•
•
•
|
Publication |
First Author: |
Schneider K |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2). |
Volume: |
291 |
Issue: |
14 |
Pages: |
7754-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winn NC |
Year: |
2017 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Deletion of UCP1 enhances ex vivo aortic vasomotor function in female but not male mice despite similar susceptibility to metabolic dysfunction. |
Volume: |
313 |
Issue: |
4 |
Pages: |
E402-E412 |
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•
•
•
•
•
|
Publication |
First Author: |
Lehr L |
Year: |
2006 |
Journal: |
FEBS Lett |
Title: |
The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture. |
Volume: |
580 |
Issue: |
19 |
Pages: |
4661-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Robidoux J |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. |
Volume: |
25 |
Issue: |
13 |
Pages: |
5466-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang Y |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1648 |
|
•
•
•
•
•
|
Publication |
First Author: |
Couplan E |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. |
Volume: |
277 |
Issue: |
45 |
Pages: |
43079-88 |
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•
•
•
•
|
Allele |
Name: |
uncoupling protein 1 (mitochondrial, proton carrier); endonuclease-mediated mutation 1, Edward T Chouchani |
Allele Type: |
Endonuclease-mediated |
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Publication |
First Author: |
Kim K |
Year: |
2024 |
Journal: |
Mol Metab |
Title: |
Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues. |
Volume: |
84 |
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Pages: |
101948 |
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Publication |
First Author: |
Li B |
Year: |
2000 |
Journal: |
Nat Med |
Title: |
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. |
Volume: |
6 |
Issue: |
10 |
Pages: |
1115-20 |
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Publication |
First Author: |
Han DH |
Year: |
2004 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. |
Volume: |
286 |
Issue: |
3 |
Pages: |
E347-53 |
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Publication |
First Author: |
Nguyen AD |
Year: |
2018 |
Journal: |
Bone |
Title: |
Uncoupling protein-1 is protective of bone mass under mild cold stress conditions. |
Volume: |
106 |
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Pages: |
167-178 |
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Publication |
First Author: |
Dupuis L |
Year: |
2009 |
Journal: |
PLoS One |
Title: |
Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e5390 |
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Publication |
First Author: |
Emmett MJ |
Year: |
2017 |
Journal: |
Nature |
Title: |
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. |
Volume: |
546 |
Issue: |
7659 |
Pages: |
544-548 |
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Publication |
First Author: |
Nakamura Y |
Year: |
2013 |
Journal: |
Biochem Biophys Res Commun |
Title: |
FABP3 and brown adipocyte-characteristic mitochondrial fatty acid oxidation enzymes are induced in beige cells in a different pathway from UCP1. |
Volume: |
441 |
Issue: |
1 |
Pages: |
42-6 |
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Publication |
First Author: |
Oelkrug R |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. |
Volume: |
285 |
Issue: |
29 |
Pages: |
21961-8 |
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Publication |
First Author: |
Shabalina IG |
Year: |
2008 |
Journal: |
Biochim Biophys Acta |
Title: |
Within brown-fat cells, UCP1-mediated fatty acid-induced uncoupling is independent of fatty acid metabolism. |
Volume: |
1777 |
Issue: |
7-8 |
Pages: |
642-50 |
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Publication |
First Author: |
Bertholet AM |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. |
Volume: |
25 |
Issue: |
4 |
Pages: |
811-822.e4 |
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Publication |
First Author: |
Antonacci MA |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Direct detection of brown adipose tissue thermogenesis in UCP1-/- mice by hyperpolarized 129Xe MR thermometry. |
Volume: |
9 |
Issue: |
1 |
Pages: |
14865 |
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Publication |
First Author: |
Véniant MM |
Year: |
2015 |
Journal: |
Cell Metab |
Title: |
Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue. |
Volume: |
21 |
Issue: |
5 |
Pages: |
731-8 |
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Publication |
First Author: |
Hagberg CE |
Year: |
2018 |
Journal: |
Cell Rep |
Title: |
Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity. |
Volume: |
24 |
Issue: |
10 |
Pages: |
2746-2756.e5 |
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Publication |
First Author: |
Kwon MM |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
FGF21-Mediated Improvements in Glucose Clearance Require Uncoupling Protein 1. |
Volume: |
13 |
Issue: |
8 |
Pages: |
1521-7 |
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Publication |
First Author: |
Li Y |
Year: |
2014 |
Journal: |
EMBO Rep |
Title: |
Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes. |
Volume: |
15 |
Issue: |
10 |
Pages: |
1069-76 |
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Publication |
First Author: |
Luijten IHN |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Glucocorticoid-Induced Obesity Develops Independently of UCP1. |
Volume: |
27 |
Issue: |
6 |
Pages: |
1686-1698.e5 |
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Publication |
First Author: |
Wang Y |
Year: |
2022 |
Journal: |
Life Metabolism |
Title: |
WTAP regulates postnatal development of brown adipose tissue by stabilizing METTL3 in mice. |
Volume: |
1 |
Issue: |
3 |
Pages: |
270-284 |
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Publication |
First Author: |
Paulo E |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism. |
Volume: |
36 |
Issue: |
12 |
Pages: |
109742 |
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Publication |
First Author: |
Fonseca TL |
Year: |
2022 |
Journal: |
Endocrinology |
Title: |
Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse. |
Volume: |
163 |
Issue: |
5 |
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Publication |
First Author: |
Ma S |
Year: |
2012 |
Journal: |
J Mol Cell Biol |
Title: |
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. |
Volume: |
4 |
Issue: |
2 |
Pages: |
88-96 |
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Publication |
First Author: |
Samms RJ |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1. |
Volume: |
11 |
Issue: |
7 |
Pages: |
991-9 |
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Publication |
First Author: |
Keipert S |
Year: |
2017 |
Journal: |
Cell Metab |
Title: |
Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. |
Volume: |
26 |
Issue: |
2 |
Pages: |
437-446.e5 |
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Publication |
First Author: |
Keipert S |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. |
Volume: |
11 |
Issue: |
1 |
Pages: |
624 |
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Publication |
First Author: |
Matesanz N |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
MKK6 controls T3-mediated browning of white adipose tissue. |
Volume: |
8 |
Issue: |
1 |
Pages: |
856 |
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Publication |
First Author: |
Shi M |
Year: |
2021 |
Journal: |
Nat Cell Biol |
Title: |
AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1. |
Volume: |
23 |
Issue: |
3 |
Pages: |
268-277 |
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