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Search results 1 to 72 out of 72 for Unc79

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Hits by Strain

Type Details Score
Protein Domain
IPR024855 | UNC79
Type: Family
Description: The Protein unc-79 homolog is an auxiliary subunit of the NALCN sodium channel complex which is a voltage-gated ion channel responsible for the resting Na+ permeability that controls neuronal excitability [, ]. This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited by extracellular Ca2+ through the Ca2+-sensing receptor []. The human NALCN channelosome has been structurally characterised []. NALCN, UNC79 and UNC80 are essential, and mutations in human NALCN and UNC80 cause severe developmental and neurological disease. In the human NALCN channelosome structure UNC79 and UNC80 form an intertwined anti-parallel superhelical assembly, which docks intracellularly onto the NALCN-FAM155A pore-forming subcomplex () [].
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Gene
57578 | UNC79
Type: gene
Organism: human
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Gene
100486994 | unc79
Type: gene
Organism: frog, western clawed
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Gene
314401 | Unc79
Type: gene
Organism: rat
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Gene
612347 | UNC79
Type: gene
Organism: dog, domestic
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Gene
467537 | UNC79
Type: gene
Organism: chimpanzee
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Gene
537528 | UNC79
Type: gene
Organism: cattle
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Gene
423426 | UNC79
Type: gene
Organism: chicken
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Gene
699262 | UNC79
Type: gene
Organism: macaque, rhesus
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Gene
101883855 | unc79
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:2684729 | Unc79
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
32620897 | J:291847
First Author: Wie J
Year: 2020
Journal: Nat Commun
Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
Volume: 11
Issue: 1
Pages: 3351
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Publication
21040849 | J:167858
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
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Protein
J3QPJ0
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
J3QMH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Publication
34929720 | -
First Author: Kschonsak M
Year: 2022
Journal: Nature
Title: Structural architecture of the human NALCN channelosome.
Volume: 603
Issue: 7899
Pages: 180-186
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Protein
Q3UN20
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
J3QP77
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
E5CYJ9
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
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Protein
J3QMK4
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
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Protein
G8JL63
Organism: Mus musculus/domesticus
Length: 2458  
Fragment?: false
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Protein
Q0KK59
Organism: Mus musculus/domesticus
Length: 2596  
Fragment?: false
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Protein
J3QNP0
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: true
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Publication
19092807 | J:145000
First Author: Lu B
Year: 2009
Journal: Nature
Title: Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.
Volume: 457
Issue: 7230
Pages: 741-4
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Publication
37183800 | J:354041
First Author: Bayat A
Year: 2023
Journal: Genet Med
Title: A new neurodevelopmental disorder linked to heterozygous variants in UNC79.
Volume: 25
Issue: 9
Pages: 100894
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Protein Coding Gene
MGP_CAROLIEiJ_G0018047 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200025693 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195017600 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220035357 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180031753 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175029101 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2684729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215039813 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005018586 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210014707 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185042806 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205012362 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230028338 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000012199 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190021280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225037923 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010012276 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005007450 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029806 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010016998 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20714347 | J:163308
 
First Author: Speca DJ
Year: 2010
Journal: PLoS Genet
Title: Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
Volume: 6
Issue: 8
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Publication
16807365 | J:111319
First Author: Nakayama M
Year: 2006
Journal: FASEB J
Title: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.
Volume: 20
Issue: 10
Pages: 1718-20
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Publication
16436185 | J:118059
First Author: Speca DJ
Year: 2006
Journal: Genes Brain Behav
Title: A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice.
Volume: 5
Issue: 1
Pages: 19-28
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Protein Domain
IPR060043 | HEAT_UNC79_C
Type: Domain
Description: This entry represents the C-terminal region of Protein unc-79 homolog from Homo sapiens and related proteins. In the Uncoordinated protein 79 (UNC79) from C.elegans, it spans nearly the entire length. This domain is composed of ��-helical HEAT repeats.The Protein unc-79 homolog is an auxiliary subunit of the NALCN sodium channel complex which is a voltage-gated ion channel responsible for the resting Na+ permeability that controls neuronal excitability [, ]. This complex is activated by neuropeptides substance P, neurotensin. In addition, the channel is inhibited by extracellular Ca2+ through the Ca2+-sensing receptor []. The human NALCN channelosome has been structurally characterised []. NALCN, UNC79 and UNC80 are essential, and mutations in human NALCN and UNC80 cause severe developmental and neurological disease. In the human NALCN channelosome structure UNC79 and UNC80 form an intertwined anti-parallel superhelical assembly, which docks intracellularly onto the NALCN-FAM155A pore-forming subcomplex () [].
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