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Search results 1 to 73 out of 73 for Unc79

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Hits by Strain

Type Details Score
Protein Domain
IPR024855 | UNC79
Type: Family
Description: The NALCN cation channel, which controls neuronal excitability, can be activated by a reduction in extracellular calcium ions. Its activation in neurons requires the proteins UNC79 and UNC80, where UNC79 indirectly associates with NALCN through its interaction with UNC80 [].
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Protein
E5CYJ9
Organism: Mus musculus/domesticus
Length: 2654  
Fragment?: false
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Gene
57578 | UNC79
Type: gene
Organism: human
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Gene
100486994 | unc79
Type: gene
Organism: frog, western clawed
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Gene
314401 | Unc79
Type: gene
Organism: rat
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Gene
612347 | UNC79
Type: gene
Organism: dog, domestic
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Gene
467537 | UNC79
Type: gene
Organism: chimpanzee
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Gene
537528 | UNC79
Type: gene
Organism: cattle
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Gene
423426 | UNC79
Type: gene
Organism: chicken
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Gene
699262 | UNC79
Type: gene
Organism: macaque, rhesus
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Gene
101883855 | unc79
Type: gene
Organism: zebrafish
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Protein Coding Gene
MGI:2684729 | Unc79
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21040849 | J:167858
First Author: Lu B
Year: 2010
Journal: Neuron
Title: Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex.
Volume: 68
Issue: 3
Pages: 488-99
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Protein
J3QP77
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
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Protein
Q3UN20
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
J3QMH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
G8JL63
Organism: Mus musculus/domesticus
Length: 2458  
Fragment?: false
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Protein
J3QPJ0
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
Q0KK59
Organism: Mus musculus/domesticus
Length: 2596  
Fragment?: false
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Protein
J3QNP0
Organism: Mus musculus/domesticus
Length: 2461  
Fragment?: true
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Publication
37183800 | J:354041
First Author: Bayat A
Year: 2023
Journal: Genet Med
Title: A new neurodevelopmental disorder linked to heterozygous variants in UNC79.
Volume: 25
Issue: 9
Pages: 100894
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Publication
32620897 | J:291847
First Author: Wie J
Year: 2020
Journal: Nat Commun
Title: Intellectual disability-associated UNC80 mutations reveal inter-subunit interaction and dendritic function of the NALCN channel complex.
Volume: 11
Issue: 1
Pages: 3351
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Protein Coding Gene
MGP_CAROLIEiJ_G0018047 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0019999 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0019975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0019985 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0019787 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2684729 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0020434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0019333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0019759 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0019870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0019859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0019946 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0019899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0020463 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019096 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0019387 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029806 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0018892 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20714347 | J:163308
 
First Author: Speca DJ
Year: 2010
Journal: PLoS Genet
Title: Conserved role of unc-79 in ethanol responses in lightweight mutant mice.
Volume: 6
Issue: 8
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Publication
16807365 | J:111319
First Author: Nakayama M
Year: 2006
Journal: FASEB J
Title: A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins.
Volume: 20
Issue: 10
Pages: 1718-20
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Publication
16436185 | J:118059
First Author: Speca DJ
Year: 2006
Journal: Genes Brain Behav
Title: A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice.
Volume: 5
Issue: 1
Pages: 19-28
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein Domain
IPR046460 | UNC80_C
Type: Domain
Description: This entry represents the C-terminal domain of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALC is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ].
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Protein Domain
IPR045852 | UNC80_central
Type: Domain
Description: This entry represents the central region of protein UNC80 from eukaryotes, a component of the NALCN sodium channel complex. NALCN is a cation voltage-independent channel activated by substance P, neurotensin, acetylcholine and noradrenaline that controls neuronal excitability. UNC80 forms a complex with UNC79 and both are key regulators of the channel and required for the proper expression and axonal localisation of NALCN. UNC80 is required for NALCN control by GPCRs and essential for its sensitivity to extracellular calcium. This protein acts as a scaffold for Src family of tyrosine kinases (SFK) and UNC-79 to mediate interaction with NALCN [, , ]. Proteins containing this domain also include some uncharacterised proteins from fungi.
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Publication
24904279 | -
 
First Author: Cochet-Bissuel M
Year: 2014
Journal: Front Cell Neurosci
Title: The sodium leak channel, NALCN, in health and disease.
Volume: 8
Pages: 132
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Publication
31690562 | -
First Author: Zhou C
Year: 2020
Journal: G3 (Bethesda)
Title: The NALCN Channel Regulator UNC-80 Functions in a Subset of Interneurons To Regulate Caenorhabditis elegans Reversal Behavior.
Volume: 10
Issue: 1
Pages: 199-210
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Protein
Q8BLN6
Organism: Mus musculus/domesticus
Length: 3326  
Fragment?: false
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Protein
A0A1D5RLV3
Organism: Mus musculus/domesticus
Length: 3258  
Fragment?: false
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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