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Search results 1 to 100 out of 216 for Unc93b1

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: UNC93B1 is a multi-transmembrane domain-containing protein that plays an essential role in signalling by the nucleotide-sensing Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9 [, ]. UNC93B1 delivers the nucleotide-sensing receptors TLR7 and TLR9 from the ER to endolysosomes []. It has been shown to recruit Syntenin-1 and dampen TLR7 signalling and prevent autoimmunity []. It also binds TLR9, and the release of TLR9 from UNC93B1 is required for TLR9 to function []. Mutations in the UNC93B1 gene that result in aberrant TLR trafficking can lead to autoimmune disease [].
Publication
First Author: Kim YM
Year: 2008
Journal: Nature
Title: UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.
Volume: 452
Issue: 7184
Pages: 234-8
Publication
First Author: Majer O
Year: 2019
Journal: Nature
Title: Release from UNC93B1 reinforces the compartmentalized activation of select TLRs.
Volume: 575
Issue: 7782
Pages: 371-374
Publication
First Author: Majer O
Year: 2019
Journal: Nature
Title: UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity.
Volume: 575
Issue: 7782
Pages: 366-370
Publication
First Author: Fukui R
Year: 2011
Journal: Immunity
Title: Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Volume: 35
Issue: 1
Pages: 69-81
Publication  
First Author: Lee BL
Year: 2013
Journal: Elife
Title: UNC93B1 mediates differential trafficking of endosomal TLRs.
Volume: 2
Pages: e00291
Publication
First Author: Pohar J
Year: 2013
Journal: J Biol Chem
Title: The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.
Volume: 288
Issue: 1
Pages: 442-54
Publication
First Author: Melo MB
Year: 2010
Journal: PLoS Pathog
Title: UNC93B1 mediates host resistance to infection with Toxoplasma gondii.
Volume: 6
Issue: 8
Pages: e1001071
Publication
First Author: Pelka K
Year: 2018
Journal: Immunity
Title: The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.
Volume: 48
Issue: 5
Pages: 911-922.e7
Publication
First Author: Crane MJ
Year: 2012
Journal: PLoS One
Title: UNC93B1 mediates innate inflammation and antiviral defense in the liver during acute murine cytomegalovirus infection.
Volume: 7
Issue: 6
Pages: e39161
Publication
First Author: Lafferty EI
Year: 2015
Journal: J Innate Immun
Title: Unc93b1 -Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection.
Volume: 7
Issue: 3
Pages: 315-30
Publication
First Author: Maschalidi S
Year: 2017
Journal: Nat Commun
Title: UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells.
Volume: 8
Issue: 1
Pages: 1640
Publication
First Author: Huh JW
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5.
Volume: 111
Issue: 19
Pages: 7072-7
Protein
Organism: Mus musculus/domesticus
Length: 138  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: true
Publication
First Author: Sasai M
Year: 2011
Journal: Immunity
Title: Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction.
Volume: 35
Issue: 1
Pages: 3-5
Publication
First Author: Fukui R
Year: 2009
Journal: J Exp Med
Title: Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
Volume: 206
Issue: 6
Pages: 1339-50
Publication
First Author: Lafferty EI
Year: 2014
Journal: Genes Immun
Title: An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.
Volume: 15
Issue: 5
Pages: 320-32
Publication
First Author: Caetano BC
Year: 2011
Journal: J Immunol
Title: Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi.
Volume: 187
Issue: 4
Pages: 1903-11
Publication
First Author: Schamber-Reis BL
Year: 2013
Journal: J Biol Chem
Title: UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major.
Volume: 288
Issue: 10
Pages: 7127-36
Publication
First Author: Panchanathan R
Year: 2013
Journal: Int Immunol
Title: Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity.
Volume: 25
Issue: 9
Pages: 521-9
Publication
First Author: Kim J
Year: 2013
Journal: J Immunol
Title: Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.
Volume: 190
Issue: 10
Pages: 5287-95
Publication  
First Author: Klammer MG
Year: 2021
Journal: Front Immunol
Title: UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b.
Volume: 12
Pages: 715774
Protein
Organism: Mus musculus/domesticus
Length: 598  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 619  
Fragment?: false
Publication
First Author: Tabeta K
Year: 2006
Journal: Nat Immunol
Title: The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Volume: 7
Issue: 2
Pages: 156-64
Publication
First Author: Ishida H
Year: 2021
Journal: Nat Struct Mol Biol
Title: Cryo-EM structures of Toll-like receptors in complex with UNC93B1.
Volume: 28
Issue: 2
Pages: 173-180
Publication
First Author: Kono DH
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.
Volume: 106
Issue: 29
Pages: 12061-6
Publication
First Author: Avalos AM
Year: 2013
Journal: J Immunol
Title: Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice.
Volume: 190
Issue: 2
Pages: 695-702
Publication
First Author: Fukui R
Year: 2016
Journal: J Immunol
Title: Type I IFN Contributes to the Phenotype of Unc93b1D34A/D34A Mice by Regulating TLR7 Expression in B Cells and Dendritic Cells.
Volume: 196
Issue: 1
Pages: 416-27
Publication
First Author: Pollard KM
Year: 2017
Journal: J Immunol
Title: Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.
Volume: 199
Issue: 11
Pages: 3739-3747
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Tabeta K
Year: 2013
Journal: Nat Immunol
Title: Respond to "No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice".
Volume: 14
Issue: 11
Pages: 1102-3
Publication
First Author: Deguine J
Year: 2013
Journal: Nat Immunol
Title: No antigen-presentation defect in Unc93b1(3d/3d) (3d) mice.
Volume: 14
Issue: 11
Pages: 1101-2
Publication
First Author: Kawashima T
Year: 2013
Journal: Immunity
Title: Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.
Volume: 38
Issue: 6
Pages: 1187-97
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: WT brain
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: Unc93b1<-/-> brain
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: WT spleen
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: Unc93b1<-/-> spleen
Detected: false
Specimen Num: 12
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: WT liver
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: Unc93b1<-/-> liver
Detected: false
Specimen Num: 14
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: WT lung
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:6887609
Age: postnatal
Image: 1
Specimen Label: Unc93b1<-/-> lung
Detected: false
Specimen Num: 16
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6887633
Age: embryonic day 13.0
Image: 2
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:6887633
Age: embryonic day 14.0
Image: 2
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6887633
Age: embryonic day 15.0
Image: 2
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6887633
Age: embryonic day 16.0
Image: 2
Specimen Label: E16
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:6887633
Age: embryonic day 17.0
Image: 2
Specimen Label: E17
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6887633
Age: embryonic day 18.0
Image: 2
Specimen Label: E18
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6887633
Age: embryonic day 19.0
Image: 2
Specimen Label: E19
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6887633
Age: postnatal day 0
Image: 2
Specimen Label: P0
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887633
Age: postnatal day 4
Image: 2
Specimen Label: P4
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887633
Age: postnatal day 8
Image: 2
Specimen Label: P8
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887633
Age: postnatal day 12
Image: 2
Specimen Label: P12
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887633
Age: postnatal month 5
Image: 2
Specimen Label: P5M
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6887634
Age: embryonic day 13.0
Image: 2
Specimen Label: E13
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689422
Stage: TS22
Assay Id: MGI:6887634
Age: embryonic day 14.0
Image: 2
Specimen Label: E14
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:6887634
Age: embryonic day 15.0
Image: 2
Specimen Label: E15
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:6887634
Age: embryonic day 16.0
Image: 2
Specimen Label: E16
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:6887634
Age: embryonic day 17.0
Image: 2
Specimen Label: E17
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6887634
Age: embryonic day 18.0
Image: 2
Specimen Label: E18
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:6887634
Age: embryonic day 19.0
Image: 2
Specimen Label: E19
Detected: true
Specimen Num: 7
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:6887634
Age: postnatal day 0
Image: 2
Specimen Label: P0
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887634
Age: postnatal day 4
Image: 2
Specimen Label: P4
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887634
Age: postnatal day 8
Image: 2
Specimen Label: P8
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887634
Age: postnatal day 12
Image: 2
Specimen Label: P12
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6887419
Assay Type: RT-PCR
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:6887634
Age: postnatal month 5
Image: 2
Specimen Label: P5M
Detected: true
Specimen Num: 12
GXD Expression  
Probe: MGI:6887449
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Widespread
Stage: TS28
Assay Id: MGI:6887612
Age: postnatal
Image: 1C WT
Specimen Label: 1C WT
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6887449
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:6887612
Age: postnatal
Image: 1C Unc93b1<-/->
Specimen Label: 1C Unc93b1<-/->
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:6887449
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6887612
Age: postnatal
Image: 1D WT NeuN
Specimen Label: 1D WT NeuN
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:6887449
Assay Type: Immunohistochemistry
Annotation Date: 2022-03-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6887612
Age: postnatal
Image: 1D WT GFAP
Specimen Label: 1D WT GFAP
Detected: true
Specimen Num: 4