|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 1 to 94 out of 94 for Usp1

0.028s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Drosophila melanogaster
Gene
Type: gene
Organism: Rattus norvegicus
Gene
Type: gene
Organism: Danio rerio
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Domain
Description: Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome [,].This entry encompasses ubiquitin-specific hydrolase 1 (MEROPS identifier C19.019). It is required for deubiquitination of monoubiquitinated proteins involved in various DNA repair pathways and is a key regulator of DNA repair mechanisms []. Substrates include monoubiquitinated PCNA [], and components FANCD2 []and FANCI []of the Fanconi anemia pathway, a genetic disorder that results in the inability to monoubiquitinate these components [].
Publication
First Author: Kim M
Year: 2016
Journal: FEBS Lett
Title: The role of USP1 autocleavage in DNA interstrand crosslink repair.
Volume: 590
Issue: 3
Pages: 340-8
Publication
First Author: Cataldo F
Year: 2013
Journal: Mol Cell Biol
Title: CAPNS1 regulates USP1 stability and maintenance of genome integrity.
Volume: 33
Issue: 12
Pages: 2485-96
Publication
First Author: Williams SA
Year: 2011
Journal: Cell
Title: USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Volume: 146
Issue: 6
Pages: 918-30
Publication
First Author: Kim JM
Year: 2009
Journal: Dev Cell
Title: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Volume: 16
Issue: 2
Pages: 314-20
Publication
First Author: Piatkov KI
Year: 2012
Journal: Mol Cell
Title: The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Volume: 48
Issue: 6
Pages: 926-33
Publication
First Author: Nijman SM
Year: 2005
Journal: Mol Cell
Title: The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Volume: 17
Issue: 3
Pages: 331-9
Protein
Organism: Mus musculus
Length: 784  
Fragment?: false
Publication
First Author: Sims AE
Year: 2007
Journal: Nat Struct Mol Biol
Title: FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
Volume: 14
Issue: 6
Pages: 564-7
Publication
First Author: Barrett AJ
Year: 2001
Journal: Biol Chem
Title: Evolutionary lines of cysteine peptidases.
Volume: 382
Issue: 5
Pages: 727-33
Publication
First Author: Chung CH
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Deubiquitinating enzymes: their diversity and emerging roles.
Volume: 266
Issue: 3
Pages: 633-40
Publication
First Author: Huang TT
Year: 2006
Journal: Nat Rev Mol Cell Biol
Title: Regulation of DNA repair by ubiquitylation.
Volume: 7
Issue: 5
Pages: 323-34
Publication
First Author: Huang TT
Year: 2006
Journal: Nat Cell Biol
Title: Regulation of monoubiquitinated PCNA by DUB autocleavage.
Volume: 8
Issue: 4
Pages: 339-47
Publication  
First Author: Moldovan GL
Year: 2009
Journal: Annu Rev Genet
Title: How the fanconi anemia pathway guards the genome.
Volume: 43
Pages: 223-49
Publication
First Author: Parmar K
Year: 2010
Journal: Stem Cells
Title: Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Volume: 28
Issue: 7
Pages: 1186-95
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell
Title: FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.
Volume: 50
Issue: 6
Pages: 908-18
Publication
First Author: Park E
Year: 2013
Journal: Mol Cell Biol
Title: Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Volume: 33
Issue: 22
Pages: 4360-70
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: false
Specimen Num: 4
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Detected: false
Specimen Num: 6
GXD Expression  
Probe: MGI:5614877
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5614913
Age: postnatal day 12
Note: Expression was detected in the femoral metaphysis.
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5614877
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:5614913
Age: postnatal day 12
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6
Detected: true
Specimen Num: 6
GXD Expression
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585772
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6-7
Image: P6/7
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 8-10
Image: P8/10
Detected: true
Specimen Num: 4
GXD Expression  
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal adult
Image: Adult
Detected: true
Specimen Num: 5
Publication
First Author: Adelman CA
Year: 2013
Journal: Nature
Title: HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Volume: 502
Issue: 7471
Pages: 381-4
Publication  
First Author: Brown AC
Year: 2005
Journal: BMC Genet
Title: Searching QTL by gene expression: analysis of diabesity.
Volume: 6
Pages: 12
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
Publication
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication      
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication
First Author: Gaudet P
Year: 2011
Journal: Brief Bioinform
Title: Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Volume: 12
Issue: 5
Pages: 449-62
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication
First Author: Lim KS
Year: 2018
Journal: Mol Cell
Title: USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Volume: 72
Issue: 6
Pages: 925-941.e4
Interaction Experiment
Description: USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Publication
First Author: Goldbraikh D
Year: 2020
Journal: EMBO Rep
Title: USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Volume: 21
Issue: 4
Pages: e48791
Publication  
First Author: Ha K
Year: 2017
Journal: Nat Commun
Title: The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites.
Volume: 8
Pages: 15751
Publication
First Author: Rahme GJ
Year: 2016
Journal: Cancer Res
Title: PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells.
Volume: 76
Issue: 10
Pages: 2964-76
Publication
First Author: Omilusik KD
Year: 2021
Journal: J Immunol
Title: Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.
Volume: 207
Issue: 5
Pages: 1377-1387