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Search results 1 to 100 out of 107 for Usp1

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Type Details Score
Gene
7398 | USP1
Type: gene
Organism: human
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Gene
479549 | USP1
Type: gene
Organism: dog, domestic
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Gene
516328 | USP1
Type: gene
Organism: cattle
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Gene
424685 | USP1
Type: gene
Organism: chicken
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Gene
322007 | usp1
Type: gene
Organism: zebrafish
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Gene
695157 | USP1
Type: gene
Organism: macaque, rhesus
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Gene
780036 | usp1
Type: gene
Organism: frog, western clawed
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Gene
313387 | Usp1
Type: gene
Organism: rat
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Gene
456901 | USP1
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2385198 | Usp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR033815 | USP1
Type: Domain
Description: Peptidase C19 contains ubiquitin hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquitinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome [, ].This entry encompasses ubiquitin-specific hydrolase 1 (MEROPS identifier C19.019). It is required for deubiquitination of monoubiquitinated proteins involved in various DNA repair pathways and is a key regulator of DNA repair mechanisms []. Substrates include monoubiquitinated PCNA [], and components FANCD2 []and FANCI []of the Fanconi anemia pathway, a genetic disorder that resultsin the inability to monoubiquitinate these components [].
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Publication
26783108 | J:229978
First Author: Kim M
Year: 2016
Journal: FEBS Lett
Title: The role of USP1 autocleavage in DNA interstrand crosslink repair.
Volume: 590
Issue: 3
Pages: 340-8
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Publication
23589330 | J:204494
First Author: Cataldo F
Year: 2013
Journal: Mol Cell Biol
Title: CAPNS1 regulates USP1 stability and maintenance of genome integrity.
Volume: 33
Issue: 12
Pages: 2485-96
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Publication
21925315 | J:207363
First Author: Williams SA
Year: 2011
Journal: Cell
Title: USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma.
Volume: 146
Issue: 6
Pages: 918-30
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Publication
15694335 | -
First Author: Nijman SM
Year: 2005
Journal: Mol Cell
Title: The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway.
Volume: 17
Issue: 3
Pages: 331-9
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Publication
23159736 | J:194097
First Author: Piatkov KI
Year: 2012
Journal: Mol Cell
Title: The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Volume: 48
Issue: 6
Pages: 926-33
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Publication
19217432 | J:146616
First Author: Kim JM
Year: 2009
Journal: Dev Cell
Title: Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Volume: 16
Issue: 2
Pages: 314-20
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Publication
17460694 | -
First Author: Sims AE
Year: 2007
Journal: Nat Struct Mol Biol
Title: FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
Volume: 14
Issue: 6
Pages: 564-7
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Protein
Q8BJQ2
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Publication
11517925 | -
First Author: Barrett AJ
Year: 2001
Journal: Biol Chem
Title: Evolutionary lines of cysteine peptidases.
Volume: 382
Issue: 5
Pages: 727-33
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Publication
10603300 | -
First Author: Chung CH
Year: 1999
Journal: Biochem Biophys Res Commun
Title: Deubiquitinating enzymes: their diversity and emerging roles.
Volume: 266
Issue: 3
Pages: 633-40
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Publication
16633336 | -
First Author: Huang TT
Year: 2006
Journal: Nat Rev Mol Cell Biol
Title: Regulation of DNA repair by ubiquitylation.
Volume: 7
Issue: 5
Pages: 323-34
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Publication
16531995 | -
First Author: Huang TT
Year: 2006
Journal: Nat Cell Biol
Title: Regulation of monoubiquitinated PCNA by DUB autocleavage.
Volume: 8
Issue: 4
Pages: 339-47
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Publication
19686080 | -
 
First Author: Moldovan GL
Year: 2009
Journal: Annu Rev Genet
Title: How the fanconi anemia pathway guards the genome.
Volume: 43
Pages: 223-49
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Publication
20506303 | J:168056
First Author: Parmar K
Year: 2010
Journal: Stem Cells
Title: Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Volume: 28
Issue: 7
Pages: 1186-95
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Publication
23806336 | J:199241
First Author: Park E
Year: 2013
Journal: Mol Cell
Title: FANCD2 activates transcription of TAp63 and suppresses tumorigenesis.
Volume: 50
Issue: 6
Pages: 908-18
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Publication
34380645 | J:309127
First Author: Omilusik KD
Year: 2021
Journal: J Immunol
Title: Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.
Volume: 207
Issue: 5
Pages: 1377-1387
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Publication
24001775 | J:206106
First Author: Park E
Year: 2013
Journal: Mol Cell Biol
Title: Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Volume: 33
Issue: 22
Pages: 4360-70
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Protein Coding Gene
MGP_CAROLIEiJ_G0026188 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028476 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028439 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028386 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028457 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028170 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2385198 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028896 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027610 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028139 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028289 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028256 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028389 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028934 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027335 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027688 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028525 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027156 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Western blot
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914326
Stage: TS26
Assay Id: MGI:5614905
Age: embryonic day 18.5
Specimen Label: None
Detected: false
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:5614877
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1914328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:5614913
Age: postnatal day 12
Note: Expression was detected in the femoral metaphysis.
Specimen Label: S6J WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5614877
Assay Type: Immunohistochemistry
Annotation Date: 2015-02-09
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1914328
Stage: TS28
Assay Id: MGI:5614913
Age: postnatal day 12
Specimen Label: S6J Usp1-/-
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6
Specimen Label: CNS
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915727
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:3585772
Age: postnatal day 2-3
Image: P2/3
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P2/3
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 4-5
Image: P4/5
Note: Expression was detected in the outer neuroblastic layer.
Specimen Label: P4/5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 6-7
Image: P6/7
Specimen Label: P6/7
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal day 8-10
Image: P8/10
Specimen Label: P8/10
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:3585153
Assay Type: RNA in situ
Annotation Date: 2005-08-30
Strength: Present
Sex: Male
Emaps: EMAPS:1915728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3585772
Age: postnatal adult
Image: Adult
Specimen Label: Adult
Detected: true
Specimen Num: 5
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Publication
24005329 | J:206104
First Author: Adelman CA
Year: 2013
Journal: Nature
Title: HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis.
Volume: 502
Issue: 7471
Pages: 381-4
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Publication
15760467 | J:99477
 
First Author: Brown AC
Year: 2005
Journal: BMC Genet
Title: Searching QTL by gene expression: analysis of diabesity.
Volume: 6
Pages: 12
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:94338
     
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
15226823 | J:93300
First Author: Blackshaw S
Year: 2004
Journal: PLoS Biol
Title: Genomic analysis of mouse retinal development.
Volume: 2
Issue: 9
Pages: E247
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
30576655 | J:269019
First Author: Lim KS
Year: 2018
Journal: Mol Cell
Title: USP1 Is Required for Replication Fork Protection in BRCA1-Deficient Tumors.
Volume: 72
Issue: 6
Pages: 925-941.e4
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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