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Search results 1 to 94 out of 94 for Usp24

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
23358 | USP24
Type: gene
Organism: human
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Gene
100497137 | usp24
Type: gene
Organism: frog, western clawed
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Gene
479558 | USP24
Type: gene
Organism: dog, domestic
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Gene
456881 | USP24
Type: gene
Organism: chimpanzee
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Gene
313427 | Usp24
Type: gene
Organism: rat
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Gene
532257 | USP24
Type: gene
Organism: cattle
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Gene
424665 | USP24
Type: gene
Organism: chicken
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Gene
325631 | usp24
Type: gene
Organism: zebrafish
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Gene
717178 | USP24
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR033382 | USP24
Type: Family
Description: Ubiquitin-specific peptidase 24 (USP24, MEROPS identifier C19.047) is a de-ubiquitinating enzyme that is associated with late-onset Parkinson's Disease []. The enzyme is known to remove ubiquitin from damage-specific DNA-binding protein 2 (DDB2), increasing its stability. DDB2 is involved in DNA damage recognition in the nucleotide excision repair pathway, and is a component of an E3 ligase that targets XPC, histones and DDB2 itself []. USP24 also de-ubiquitinates p53, and cells are resistant to apoptosis following UV irradiation if USP24 is depleted because p53 is stabilized []. Single-nucleotide polymorphisms of the USP24 gene have been identified in lung cancer malignancy and could be diagnostic markers for the disease []. The USP24 gene is up-regulated when the USP9X gene is down-regulated by shRNA, leading to increased survival of B-cell myeloma cells []. USP24 positively regulates ferritinophagy, a process in which ferritin is degraded in lysosomes and releases free iron [].
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Protein Coding Gene
MGI:1919936 | Usp24
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23159851 | -
First Author: Zhang L
Year: 2012
Journal: Cell Cycle
Title: The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.
Volume: 11
Issue: 23
Pages: 4378-84
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Publication
25578727 | -
First Author: Zhang L
Year: 2015
Journal: Cell Rep
Title: The deubiquitinating enzyme USP24 is a regulator of the UV damage response.
Volume: 10
Issue: 2
Pages: 140-7
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Publication
38491202 | J:348295
First Author: Young MJ
Year: 2024
Journal: Cell Death Differ
Title: USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy.
Volume: 31
Issue: 5
Pages: 574-591
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Publication
20302855 | -
First Author: Wu YR
Year: 2010
Journal: Clin Chim Acta
Title: Ubiquitin specific proteases USP24 and USP40 and ubiquitin thiolesterase UCHL1 polymorphisms have synergic effect on the risk of Parkinson's disease among Taiwanese.
Volume: 411
Issue: 13-14
Pages: 955-8
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Publication
26568301 | -
First Author: Wang YC
Year: 2016
Journal: Oncogene
Title: Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
Volume: 35
Issue: 28
Pages: 3669-80
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Publication
25814533 | -
First Author: Peterson LF
Year: 2015
Journal: Blood
Title: Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.
Volume: 125
Issue: 23
Pages: 3588-97
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Publication
29695420 | -
 
First Author: Sun Y
Year: 2018
Journal: J Virol
Title: Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism.
Volume: 92
Issue: 13
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Publication
33355202 | J:303991
First Author: Bedekovics T
Year: 2021
Journal: Cancer Res
Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
Volume: 81
Issue: 5
Pages: 1321-1331
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Protein
B1AY13
Organism: Mus musculus/domesticus
Length: 2617  
Fragment?: false
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Protein
E9PV45
Organism: Mus musculus/domesticus
Length: 2618  
Fragment?: false
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Protein Coding Gene
MGP_CAROLIEiJ_G0026230 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028480 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028427 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028499 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028213 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1919936 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0028939 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0027649 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028330 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028298 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028431 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0028975 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027375 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0027730 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028564 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027199 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_09
Specimen Label: euxassay_009940_09
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_10
Specimen Label: euxassay_009940_10
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_11
Specimen Label: euxassay_009940_11
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_12
Specimen Label: euxassay_009940_12
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_13
Specimen Label: euxassay_009940_13
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_14
Specimen Label: euxassay_009940_14
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_15
Specimen Label: euxassay_009940_15
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
 
Probe: MGI:4417574
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1777923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4829133
Age: embryonic day 14.5
Image: euxassay_009940_16
Specimen Label: euxassay_009940_16
Detected: true
Specimen Num: 8
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Publication
26811477 | J:230444
First Author: Jahan AS
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling.
Volume: 113
Issue: 6
Pages: E705-14
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:175295
     
First Author: Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP)
Year: 2011
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Usp24<em2Smoc> | MGI:7293094
Name: ubiquitin specific peptidase 24; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Usp24<em1Smoc> | MGI:7293093
Name: ubiquitin specific peptidase 24; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:7718311 | C57BL/6JSmoc-Usp24<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Protein Domain
IPR033384 | USP40
Type: Family
Description: Ubiquitin-specific peptidase 40 (USP40, MEROPS identifier C19.069) is a de-ubiquitinating enzyme which is associated with late-onset Parkinson's Disease, possibly acting synergistically with USP24 []. The enzyme has not been biochemically characterised.
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Publication
27991932 | J:243159
First Author: Wang SA
Year: 2017
Journal: Oncogene
Title: EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.
Volume: 36
Issue: 21
Pages: 2930-2945
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Protein
Q8BWR4
Organism: Mus musculus/domesticus
Length: 1235  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom