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Search results 1 to 100 out of 976 for Vav1

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Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Domain
Type: Family
Description: Vav protein family members are multiple domain proteins, including Vav from flies and Vav1/2/3 from mammals. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a compound domain having SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry includes mammalian Vav1 and its homologues.
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein
Organism: Mus musculus
Length: 806  
Fragment?: false
Publication
First Author: Kaminski S
Year: 2012
Journal: Oncoimmunology
Title: The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis.
Volume: 1
Issue: 5
Pages: 600-608
Protein
Organism: Mus musculus
Length: 83  
Fragment?: false
Publication
First Author: Trenkle T
Year: 2000
Journal: Gene
Title: Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Volume: 245
Issue: 1
Pages: 139-49
Publication
First Author: Dekel I
Year: 2000
Journal: FEBS Lett
Title: Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.
Volume: 472
Issue: 1
Pages: 99-104
Publication
First Author: Fernández-Espartero CH
Year: 2013
Journal: J Cell Sci
Title: GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
Volume: 126
Issue: Pt 10
Pages: 2285-93
Publication
First Author: Swat W
Year: 2005
Journal: Immunol Res
Title: The Vav family: at the crossroads of signaling pathways.
Volume: 32
Issue: 1-3
Pages: 259-65
Publication
First Author: Spurrell DR
Year: 2009
Journal: J Immunol
Title: Vav1 regulates the migration and adhesion of dendritic cells.
Volume: 183
Issue: 1
Pages: 310-8
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
Publication      
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
Protein
Organism: Mus musculus
Length: 166  
Fragment?: false
Protein
Organism: Mus musculus
Length: 146  
Fragment?: true
Publication
First Author: Ksionda O
Year: 2012
Journal: J Cell Sci
Title: Mechanism and function of Vav1 localisation in TCR signalling.
Volume: 125
Issue: Pt 22
Pages: 5302-14
Publication
First Author: Raberger J
Year: 2008
Journal: Eur J Immunol
Title: Impaired T-cell development in the absence of Vav1 and Itk.
Volume: 38
Issue: 12
Pages: 3530-42
Publication
First Author: Manetz TS
Year: 2001
Journal: Mol Cell Biol
Title: Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.
Volume: 21
Issue: 11
Pages: 3763-74
Publication
First Author: Hornstein I
Year: 2004
Journal: Cell Signal
Title: Vav proteins, masters of the world of cytoskeleton organization.
Volume: 16
Issue: 1
Pages: 1-11
Publication
First Author: Jux B
Year: 2013
Journal: Int Immunol
Title: Vav1 regulates MHCII expression in murine resting and activated B cells.
Volume: 25
Issue: 5
Pages: 307-17
Publication
First Author: Haubert D
Year: 2012
Journal: Transpl Immunol
Title: Vav1 GEF activity is required for T cell mediated allograft rejection.
Volume: 26
Issue: 4
Pages: 212-9
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Publication
First Author: Swat W
Year: 2003
Journal: Int Immunol
Title: Essential role for Vav1 in activation, but not development, of gammadelta T cells.
Volume: 15
Issue: 2
Pages: 215-21
Publication
First Author: Saveliev A
Year: 2009
Journal: Sci Signal
Title: Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Volume: 2
Issue: 101
Pages: ra83
Publication
First Author: Ardouin L
Year: 2003
Journal: Eur J Immunol
Title: Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse.
Volume: 33
Issue: 3
Pages: 790-7
Publication
First Author: Ming W
Year: 2007
Journal: Mol Cell Biol
Title: The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
Volume: 27
Issue: 1
Pages: 312-23
Publication
First Author: Krawczyk C
Year: 2002
Journal: Immunity
Title: Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.
Volume: 16
Issue: 3
Pages: 331-43
Publication
First Author: Chiang J
Year: 2011
Journal: PLoS One
Title: Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
Volume: 6
Issue: 4
Pages: e18542
Publication
First Author: Graham DB
Year: 2006
Journal: J Immunol
Title: Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.
Volume: 177
Issue: 4
Pages: 2349-55
Publication
First Author: Zenker S
Year: 2014
Journal: J Immunol
Title: A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.
Volume: 192
Issue: 6
Pages: 2830-2836
Publication
First Author: Lawson CD
Year: 2011
Journal: J Immunol
Title: P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Volume: 186
Issue: 3
Pages: 1467-76
Publication
First Author: Robles-Valero J
Year: 2017
Journal: Cancer Cell
Title: A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Volume: 32
Issue: 5
Pages: 608-623.e9
Publication
First Author: Qu P
Year: 2016
Journal: Stem Cells
Title: Vav1 Regulates Mesenchymal Stem Cell Differentiation Decision Between Adipocyte and Chondrocyte via Sirt1.
Volume: 34
Issue: 7
Pages: 1934-46
Publication
First Author: Strijbis K
Year: 2013
Journal: PLoS Pathog
Title: Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.
Volume: 9
Issue: 6
Pages: e1003446
Publication
First Author: Wells CM
Year: 2005
Journal: Exp Cell Res
Title: Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.
Volume: 310
Issue: 2
Pages: 303-10
Publication
First Author: Kassem S
Year: 2016
Journal: PLoS Genet
Title: A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
Volume: 12
Issue: 7
Pages: e1006185
Publication
First Author: Phillipson M
Year: 2009
Journal: J Immunol
Title: Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature.
Volume: 182
Issue: 11
Pages: 6870-8
Publication
First Author: Zvezdova E
Year: 2016
Journal: Sci Signal
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Volume: 9
Issue: 428
Pages: ra51
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 845  
Fragment?: false
Protein
Organism: Mus musculus
Length: 821  
Fragment?: false
Protein
Organism: Mus musculus
Length: 821  
Fragment?: false
Publication
First Author: Pearce AC
Year: 2004
Journal: J Biol Chem
Title: Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
Volume: 279
Issue: 52
Pages: 53955-62
Publication
First Author: Charvet C
Year: 2006
Journal: J Immunol
Title: Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Volume: 177
Issue: 8
Pages: 5024-31
Publication
First Author: Reynolds LF
Year: 2002
Journal: J Exp Med
Title: Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.
Volume: 195
Issue: 9
Pages: 1103-14
Publication
First Author: Prisco A
Year: 2005
Journal: Immunity
Title: Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.
Volume: 23
Issue: 3
Pages: 263-74
Publication
First Author: David R
Year: 2009
Journal: Blood
Title: T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
Volume: 113
Issue: 16
Pages: 3696-705
Publication
First Author: Sanchez-Aguilera A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.
Volume: 108
Issue: 23
Pages: 9607-12
Publication
First Author: Ruiz S
Year: 2009
Journal: PLoS One
Title: The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Volume: 4
Issue: 12
Pages: e8229
Publication
First Author: Reynolds LF
Year: 2004
Journal: J Biol Chem
Title: Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.
Volume: 279
Issue: 18
Pages: 18239-46
Publication
First Author: Gogishvili T
Year: 2008
Journal: Eur J Immunol
Title: Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.
Volume: 38
Issue: 9
Pages: 2528-33
Publication
First Author: Koncz G
Year: 2008
Journal: Cell Death Differ
Title: Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation and Fas-mediated cell death signaling.
Volume: 15
Issue: 3
Pages: 494-503
Allele
Name: COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
Allele Type: Transgenic
Attribute String: Null/knockout, Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion 1, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for plain_sight.
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Delayed.
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for tardive.
Publication      
First Author: Choi JH
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Belated.
Publication      
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Late.
Publication
First Author: Korn T
Year: 2003
Journal: J Neuroimmunol
Title: Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming.
Volume: 139
Issue: 1-2
Pages: 17-26
Publication
First Author: Lazer G
Year: 2007
Journal: Cell Signal
Title: The association of Sam68 with Vav1 contributes to tumorigenesis.
Volume: 19
Issue: 12
Pages: 2479-86
Publication
First Author: Sakai H
Year: 2006
Journal: Bone
Title: Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.
Volume: 39
Issue: 6
Pages: 1290-301
Publication
First Author: Colucci F
Year: 2001
Journal: J Exp Med
Title: Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.
Volume: 193
Issue: 12
Pages: 1413-24
Publication
First Author: De Vita S
Year: 2018
Journal: Stem Cells
Title: The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients.
Volume: 36
Issue: 3
Pages: 446-457
Publication
First Author: Jacob CO
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
Volume: 109
Issue: 2
Pages: E59-67
Publication
First Author: Malhotra S
Year: 2009
Journal: J Biol Chem
Title: B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
Volume: 284
Issue: 36
Pages: 24088-97
Strain
Attribute String: mutant strain, chemically induced mutation, coisogenic
Publication
First Author: Faccio R
Year: 2005
Journal: Nat Med
Title: Vav3 regulates osteoclast function and bone mass.
Volume: 11
Issue: 3
Pages: 284-90
Publication
First Author: Chang JW
Year: 2009
Journal: Int Immunol
Title: hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
Volume: 21
Issue: 12
Pages: 1351-61
Allele
Name: transgene insertion, Cristin G Print
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Allele
Name: transgene insertion, Philippe Bouillet
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
Publication categories: ProxyCollection
Publication
First Author: Tanaka Y
Year: 2005
Journal: Blood
Title: Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.
Volume: 106
Issue: 4
Pages: 1286-95
Publication
First Author: Hebeis B
Year: 2005
Journal: Blood
Title: Vav proteins are required for B-lymphocyte responses to LPS.
Volume: 106
Issue: 2
Pages: 635-40
Publication
First Author: Madureira PA
Year: 2005
Journal: J Biol Chem
Title: Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.
Volume: 280
Issue: 45
Pages: 37310-8
Publication
First Author: Pires de Miranda M
Year: 2008
Journal: PLoS One
Title: The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly.
Volume: 3
Issue: 2
Pages: e1654
Publication
First Author: Cella M
Year: 2004
Journal: J Exp Med
Title: Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
Volume: 200
Issue: 6
Pages: 817-23
Publication
First Author: Pearce AC
Year: 2007
Journal: Biochem J
Title: Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.
Volume: 401
Issue: 3
Pages: 753-61
Publication
First Author: Fujikawa K
Year: 2003
Journal: J Exp Med
Title: Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.
Volume: 198
Issue: 10
Pages: 1595-608
Publication
First Author: Krawczyk CM
Year: 2005
Journal: J Immunol
Title: Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b.
Volume: 174
Issue: 3
Pages: 1472-8
Publication
First Author: Arana E
Year: 2008
Journal: Immunity
Title: Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
Volume: 28
Issue: 1
Pages: 88-99
Publication
First Author: Hall AB
Year: 2006
Journal: Immunity
Title: Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.
Volume: 24
Issue: 3
Pages: 305-16
Publication
First Author: Chen K
Year: 2011
Journal: Blood
Title: Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state.
Volume: 117
Issue: 21
Pages: 5744-50
Publication
First Author: Pearce AC
Year: 2002
Journal: Blood
Title: Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.
Volume: 100
Issue: 10
Pages: 3561-9
Publication
First Author: Utomo A
Year: 2006
Journal: J Immunol
Title: Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox).
Volume: 177
Issue: 9
Pages: 6388-97
Publication
First Author: Martin H
Year: 2013
Journal: J Clin Invest
Title: Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Volume: 123
Issue: 10
Pages: 4449-63
Publication
First Author: Bachmaier K
Year: 2000
Journal: Nature
Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Volume: 403
Issue: 6766
Pages: 211-6
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus