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Search results 1 to 100 out of 766 for Vav1

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
key_979838 | Vav1
Type: gene
Organism: Not Specified
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Gene
7409 | VAV1
Type: gene
Organism: human
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Gene
100497964 | vav1
Type: gene
Organism: frog, western clawed
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Gene
25156 | Vav1
Type: gene
Organism: rat
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Gene
485016 | VAV1
Type: gene
Organism: dog, domestic
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Gene
455647 | VAV1
Type: gene
Organism: chimpanzee
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Gene
617345 | VAV1
Type: gene
Organism: cattle
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Gene
100424246 | VAV1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028530 | Vav1
Type: Family
Description: Vav protein family members are multiple domain proteins, including Vav from flies and Vav1/2/3 from mammals. They have a calponin homology (CH) domain, an acidic domain (AC), a Dbl homology (DH) domain, a pleckstrin homology (PH) domain, a cysteine-rich (CR) domain containing a zinc finger, and a compound domain having SH2 and SH3 domains. Therefore they may participate in the activity of several pathways [, ]. They are signal transducer proteins that couple tyrosine kinase signals with the activation of the Rho/Rac GTPases, [, , ]. This entry includes mammalian Vav1 and its homologues.
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Protein Coding Gene
MGI:98923 | Vav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8VDU4
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Publication
22934252 | J:197583
First Author: Kaminski S
Year: 2012
Journal: Oncoimmunology
Title: The protooncogene Vav1 regulates murine leukemia virus-induced T-cell leukemogenesis.
Volume: 1
Issue: 5
Pages: 600-608
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Protein
Q3TAF7
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
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Publication
23525006 | -
First Author: Fernández-Espartero CH
Year: 2013
Journal: J Cell Sci
Title: GTP exchange factor Vav regulates guided cell migration by coupling guidance receptor signalling to local Rac activation.
Volume: 126
Issue: Pt 10
Pages: 2285-93
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Publication
10713454 | -
First Author: Trenkle T
Year: 2000
Journal: Gene
Title: Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors.
Volume: 245
Issue: 1
Pages: 139-49
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Publication
10781813 | -
First Author: Dekel I
Year: 2000
Journal: FEBS Lett
Title: Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav.
Volume: 472
Issue: 1
Pages: 99-104
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Publication
16106078 | -
First Author: Swat W
Year: 2005
Journal: Immunol Res
Title: The Vav family: at the crossroads of signaling pathways.
Volume: 32
Issue: 1-3
Pages: 259-65
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Protein
O08526
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
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Protein
Q3V0U7
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Publication
19542442 | J:149972
First Author: Spurrell DR
Year: 2009
Journal: J Immunol
Title: Vav1 regulates the migration and adhesion of dendritic cells.
Volume: 183
Issue: 1
Pages: 310-8
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Publication
32992343 | J:303756
First Author: Fukumoto K
Year: 2020
Journal: Blood
Title: VAV1 mutations contribute to development of T-cell neoplasms in mice.
Volume: 136
Issue: 26
Pages: 3018-3032
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Publication
14607270 | -
First Author: Hornstein I
Year: 2004
Journal: Cell Signal
Title: Vav proteins, masters of the world of cytoskeleton organization.
Volume: 16
Issue: 1
Pages: 1-11
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Publication
22956543 | J:190160
First Author: Ksionda O
Year: 2012
Journal: J Cell Sci
Title: Mechanism and function of Vav1 localisation in TCR signalling.
Volume: 125
Issue: Pt 22
Pages: 5302-14
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Publication
19009524 | J:141390
First Author: Raberger J
Year: 2008
Journal: Eur J Immunol
Title: Impaired T-cell development in the absence of Vav1 and Itk.
Volume: 38
Issue: 12
Pages: 3530-42
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Protein
P27870
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Publication
11340169 | J:109518
First Author: Manetz TS
Year: 2001
Journal: Mol Cell Biol
Title: Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.
Volume: 21
Issue: 11
Pages: 3763-74
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Publication
23391492 | J:199968
First Author: Jux B
Year: 2013
Journal: Int Immunol
Title: Vav1 regulates MHCII expression in murine resting and activated B cells.
Volume: 25
Issue: 5
Pages: 307-17
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Publication
22456277 | J:190162
First Author: Haubert D
Year: 2012
Journal: Transpl Immunol
Title: Vav1 GEF activity is required for T cell mediated allograft rejection.
Volume: 26
Issue: 4
Pages: 212-9
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Publication
12578851 | J:110987
First Author: Swat W
Year: 2003
Journal: Int Immunol
Title: Essential role for Vav1 in activation, but not development, of gammadelta T cells.
Volume: 15
Issue: 2
Pages: 215-21
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Publication
12616499 | J:82412
First Author: Ardouin L
Year: 2003
Journal: Eur J Immunol
Title: Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse.
Volume: 33
Issue: 3
Pages: 790-7
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Publication
20009105 | J:190087
First Author: Saveliev A
Year: 2009
Journal: Sci Signal
Title: Function of the nucleotide exchange activity of vav1 in T cell development and activation.
Volume: 2
Issue: 101
Pages: ra83
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Publication
17060455 | J:117685
First Author: Ming W
Year: 2007
Journal: Mol Cell Biol
Title: The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity.
Volume: 27
Issue: 1
Pages: 312-23
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Publication
11911819 | J:111206
First Author: Krawczyk C
Year: 2002
Journal: Immunity
Title: Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells.
Volume: 16
Issue: 3
Pages: 331-43
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Publication
21490975 | J:172283
First Author: Chiang J
Year: 2011
Journal: PLoS One
Title: Cbl enforces Vav1 dependence and a restricted pathway of T cell development.
Volume: 6
Issue: 4
Pages: e18542
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Publication
16887996 | J:138391
First Author: Graham DB
Year: 2006
Journal: J Immunol
Title: Vav1 controls DAP10-mediated natural cytotoxicity by regulating actin and microtubule dynamics.
Volume: 177
Issue: 4
Pages: 2349-55
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Publication
21178006 | J:168922
First Author: Lawson CD
Year: 2011
Journal: J Immunol
Title: P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses.
Volume: 186
Issue: 3
Pages: 1467-76
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Publication
24532586 | J:209904
First Author: Zenker S
Year: 2014
Journal: J Immunol
Title: A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.
Volume: 192
Issue: 6
Pages: 2830-2836
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Protein
Q3UAH3
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3UAV5
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3U8U1
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3U4K7
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3TXC4
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3UAG9
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
E9PXI0
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q3U9E2
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Protein
Q3U670
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Publication
29136506 | J:248841
First Author: Robles-Valero J
Year: 2017
Journal: Cancer Cell
Title: A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.
Volume: 32
Issue: 5
Pages: 608-623.e9
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Publication
16137676 | J:102824
First Author: Wells CM
Year: 2005
Journal: Exp Cell Res
Title: Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.
Volume: 310
Issue: 2
Pages: 303-10
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Publication
26990002 | J:238115
First Author: Qu P
Year: 2016
Journal: Stem Cells
Title: Vav1 Regulates Mesenchymal Stem Cell Differentiation Decision Between Adipocyte and Chondrocyte via Sirt1.
Volume: 34
Issue: 7
Pages: 1934-46
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Publication
27438086 | J:234175
First Author: Kassem S
Year: 2016
Journal: PLoS Genet
Title: A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.
Volume: 12
Issue: 7
Pages: e1006185
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Publication
23825946 | J:213379
First Author: Strijbis K
Year: 2013
Journal: PLoS Pathog
Title: Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages.
Volume: 9
Issue: 6
Pages: e1003446
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Publication
32277014 | J:304404
 
First Author: Salaymeh Y
Year: 2020
Journal: Life Sci Alliance
Title: Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
Volume: 3
Issue: 5
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Publication
19454683 | J:148862
First Author: Phillipson M
Year: 2009
Journal: J Immunol
Title: Vav1 is essential for mechanotactic crawling and migration of neutrophils out of the inflamed microvasculature.
Volume: 182
Issue: 11
Pages: 6870-8
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Publication
29991650 | J:284464
 
First Author: Gaud G
Year: 2018
Journal: Sci Signal
Title: The costimulatory molecule CD226 signals through VAV1 to amplify TCR signals and promote IL-17 production by CD4+ T cells.
Volume: 11
Issue: 538
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Publication
17015685 | J:139456
First Author: Charvet C
Year: 2006
Journal: J Immunol
Title: Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression.
Volume: 177
Issue: 8
Pages: 5024-31
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Publication
27188442 | J:259331
First Author: Zvezdova E
Year: 2016
Journal: Sci Signal
Title: Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.
Volume: 9
Issue: 428
Pages: ra51
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Publication
15456756 | J:95165
First Author: Pearce AC
Year: 2004
Journal: J Biol Chem
Title: Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.
Volume: 279
Issue: 52
Pages: 53955-62
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Publication
11994416 | J:124747
First Author: Reynolds LF
Year: 2002
Journal: J Exp Med
Title: Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways.
Volume: 195
Issue: 9
Pages: 1103-14
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Publication
16169499 | J:113270
First Author: Prisco A
Year: 2005
Journal: Immunity
Title: Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells.
Volume: 23
Issue: 3
Pages: 263-74
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Publication
19060239 | J:148304
First Author: David R
Year: 2009
Journal: Blood
Title: T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue.
Volume: 113
Issue: 16
Pages: 3696-705
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Publication
32341385 | J:289793
First Author: Kang IS
Year: 2020
Journal: Sci Rep
Title: Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation.
Volume: 10
Issue: 1
Pages: 7024
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Publication
21606370 | J:173335
First Author: Sanchez-Aguilera A
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells.
Volume: 108
Issue: 23
Pages: 9607-12
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Publication
20011522 | J:155962
First Author: Ruiz S
Year: 2009
Journal: PLoS One
Title: The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis.
Volume: 4
Issue: 12
Pages: e8229
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Publication
14764585 | J:124423
First Author: Reynolds LF
Year: 2004
Journal: J Biol Chem
Title: Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1.
Volume: 279
Issue: 18
Pages: 18239-46
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Publication
38565808 | J:361009
First Author: Marrocco R
Year: 2024
Journal: Cell Mol Life Sci
Title: Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.
Volume: 81
Issue: 1
Pages: 161
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Publication
18792405 | J:141230
First Author: Gogishvili T
Year: 2008
Journal: Eur J Immunol
Title: Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not phosphoinositide 3-kinase in primary peripheral T cells.
Volume: 38
Issue: 9
Pages: 2528-33
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Publication
18064043 | J:146382
First Author: Koncz G
Year: 2008
Journal: Cell Death Differ
Title: Regulating Vav1 phosphorylation by the SHP-1 tyrosine phosphatase is a fine-tuning mechanism for the negative regulation of DISC formation and Fas-mediated cell death signaling.
Volume: 15
Issue: 3
Pages: 494-503
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Publication
- | J:265128
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for tardive.
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Publication
- | J:265130
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for plain_sight.
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Publication
- | J:272527
     
First Author: Choi JH
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Belated.
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Publication
- | J:272528
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Delayed.
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Publication
- | J:272529
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Late.
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Publication
12799016 | J:119041
First Author: Korn T
Year: 2003
Journal: J Neuroimmunol
Title: Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming.
Volume: 139
Issue: 1-2
Pages: 17-26
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Publication
17855053 | -
First Author: Lazer G
Year: 2007
Journal: Cell Signal
Title: The association of Sam68 with Vav1 contributes to tumorigenesis.
Volume: 19
Issue: 12
Pages: 2479-86
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Publication
35443168 | J:325006
First Author: Cortes JR
Year: 2022
Journal: Cell Rep
Title: Oncogenic Vav1-Myo1f induces therapeutically targetable macrophage-rich tumor microenvironment in peripheral T cell lymphoma.
Volume: 39
Issue: 3
Pages: 110695
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Publication
16950670 | J:116971
First Author: Sakai H
Year: 2006
Journal: Bone
Title: Activated c-Fms recruits Vav and Rac during CSF-1-induced cytoskeletal remodeling and spreading in osteoclasts.
Volume: 39
Issue: 6
Pages: 1290-301
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Publication
11413196 | J:70010
First Author: Colucci F
Year: 2001
Journal: J Exp Med
Title: Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms.
Volume: 193
Issue: 12
Pages: 1413-24
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Publication
29235178 | J:260991
First Author: De Vita S
Year: 2018
Journal: Stem Cells
Title: The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients.
Volume: 36
Issue: 3
Pages: 446-457
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Publication
22203994 | J:245280
First Author: Jacob CO
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase.
Volume: 109
Issue: 2
Pages: E59-67
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Strain
MGI:5564664 | C57BL/6JAnu-Vav1<m1Anu>/AnuApb
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Publication
19586920 | J:154884
First Author: Malhotra S
Year: 2009
Journal: J Biol Chem
Title: B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
Volume: 284
Issue: 36
Pages: 24088-97
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Publication
15711558 | J:97055
First Author: Faccio R
Year: 2005
Journal: Nat Med
Title: Vav3 regulates osteoclast function and bone mass.
Volume: 11
Issue: 3
Pages: 284-90
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Publication
15845902 | J:117328
First Author: Tanaka Y
Year: 2005
Journal: Blood
Title: Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.
Volume: 106
Issue: 4
Pages: 1286-95
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Publication
19880579 | J:155458
First Author: Chang JW
Year: 2009
Journal: Int Immunol
Title: hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
Volume: 21
Issue: 12
Pages: 1351-61
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Publication
15811961 | J:107443
First Author: Hebeis B
Year: 2005
Journal: Blood
Title: Vav proteins are required for B-lymphocyte responses to LPS.
Volume: 106
Issue: 2
Pages: 635-40
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Publication
16150693 | J:102899
First Author: Madureira PA
Year: 2005
Journal: J Biol Chem
Title: Murine gamma-herpesvirus 68 latency protein M2 binds to Vav signaling proteins and inhibits B-cell receptor-induced cell cycle arrest and apoptosis in WEHI-231 B cells.
Volume: 280
Issue: 45
Pages: 37310-8
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Publication
15365099 | J:93939
First Author: Cella M
Year: 2004
Journal: J Exp Med
Title: Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
Volume: 200
Issue: 6
Pages: 817-23
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Publication
18301737 | J:132884
First Author: Pires de Miranda M
Year: 2008
Journal: PLoS One
Title: The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly.
Volume: 3
Issue: 2
Pages: e1654
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Publication
18191593 | J:131150
First Author: Arana E
Year: 2008
Journal: Immunity
Title: Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.
Volume: 28
Issue: 1
Pages: 88-99
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Publication
16546099 | J:113323
First Author: Hall AB
Year: 2006
Journal: Immunity
Title: Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis.
Volume: 24
Issue: 3
Pages: 305-16
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Publication
15661906 | J:96411
First Author: Krawczyk CM
Year: 2005
Journal: J Immunol
Title: Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b.
Volume: 174
Issue: 3
Pages: 1472-8
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Publication
21427288 | J:173265
First Author: Chen K
Year: 2011
Journal: Blood
Title: Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state.
Volume: 117
Issue: 21
Pages: 5744-50
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Publication
14623913 | J:86654
First Author: Fujikawa K
Year: 2003
Journal: J Exp Med
Title: Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.
Volume: 198
Issue: 10
Pages: 1595-608
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Publication
17054426 | J:118576
First Author: Pearce AC
Year: 2007
Journal: Biochem J
Title: Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3.
Volume: 401
Issue: 3
Pages: 753-61
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Publication
12411320 | J:115524
First Author: Pearce AC
Year: 2002
Journal: Blood
Title: Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C.
Volume: 100
Issue: 10
Pages: 3561-9
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Publication
10646608 | J:76896
First Author: Bachmaier K
Year: 2000
Journal: Nature
Title: Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b.
Volume: 403
Issue: 6766
Pages: 211-6
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Publication
17056570 | J:140509
First Author: Utomo A
Year: 2006
Journal: J Immunol
Title: Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox).
Volume: 177
Issue: 9
Pages: 6388-97
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Publication
24091327 | J:203981
First Author: Martin H
Year: 2013
Journal: J Clin Invest
Title: Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.
Volume: 123
Issue: 10
Pages: 4449-63
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Publication
29704636 | J:303325
 
First Author: Fehrenbach MK
Year: 2018
Journal: Ann Anat
Title: Decreased microglial numbers in Vav1-Cre+:dicer knock-out mice suggest a second source of microglia beyond yolk sac macrophages.
Volume: 218
Pages: 190-198
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Protein Coding Gene
MGP_CAROLIEiJ_G0021813 | -
Type: protein_coding_gene
Organism: Mus caroli
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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