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Search results 1 to 100 out of 523 for Vhl

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7428 | VHL
Type: gene
Organism: human
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Gene
549121 | vhl
Type: gene
Organism: frog, western clawed
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Gene
106996285 | VHL
Type: gene
Organism: macaque, rhesus
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Gene
24874 | Vhl
Type: gene
Organism: rat
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Gene
494000 | VHL
Type: gene
Organism: dog, domestic
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Gene
749769 | VHL
Type: gene
Organism: chimpanzee
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Gene
540957 | VHL
Type: gene
Organism: cattle
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Gene
416117 | VHL
Type: gene
Organism: chicken
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Gene
791202 | vhl
Type: gene
Organism: zebrafish
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Protein Domain
IPR002714 | VHL
Type: Family
Description: VHL (von Hippel-Lindau disease tumor suppressor) is a component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins []. Human VHL has been demonstrated to form a ternary complex with elonginB and elonginC proteins []. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor mRNA. VHL appears to act as the target recruitment subunit in the E3 ubiquitin ligase complex and recruit hydroxylated hypoxia-inducible factor (HIF) under normal oxygen conditions []. VHL is also involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases []. Like human VHL, Drosophila VHL complex containing Cul-2, Rbx1, Elongins B and C, exhibits E3 ubiquitin ligase activity []. However, proteins in this entry also include Von Hippel-Lindau-like (VHLL) protein from human. It may has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex [].
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Protein Coding Gene
MGI:103223 | Vhl
Type: protein_coding_gene
Organism: mouse, laboratory
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Gene
391104 | VHLL
Type: gene
Organism: human
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Gene
7411 | VBP1
Type: gene
Organism: human
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Publication
10205047 | -
First Author: Stebbins CE
Year: 1999
Journal: Science
Title: Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Volume: 284
Issue: 5413
Pages: 455-61
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Publication
14757845 | J:88007
First Author: Qi H
Year: 2004
Journal: Mol Cancer Res
Title: Molecular cloning and characterization of the von Hippel-Lindau-like protein.
Volume: 2
Issue: 1
Pages: 43-52
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Protein
Q3TTE7
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Protein
P40338
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: false
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Publication
12050673 | J:77389
First Author: Hon WC
Year: 2002
Journal: Nature
Title: Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Volume: 417
Issue: 6892
Pages: 975-8
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Publication
9122164 | -
First Author: Pause A
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.
Volume: 94
Issue: 6
Pages: 2156-61
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Publication
11006129 | -
First Author: Aso T
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.
Volume: 276
Issue: 1
Pages: 355-61
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Publication
10944113 | -
First Author: Tanimoto K
Year: 2000
Journal: EMBO J
Title: Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein.
Volume: 19
Issue: 16
Pages: 4298-309
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Publication
10857749 | J:62187
First Author: Woodward ER
Year: 2000
Journal: Genomics
Title: Comparative sequence analysis of the VHL tumor suppressor gene.
Volume: 65
Issue: 3
Pages: 253-65
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Publication
19620968 | J:158136
First Author: Thoma CR
Year: 2009
Journal: Nat Cell Biol
Title: VHL loss causes spindle misorientation and chromosome instability.
Volume: 11
Issue: 8
Pages: 994-1001
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Publication
21811636 | J:174924
First Author: Miró-Murillo M
Year: 2011
Journal: PLoS One
Title: Acute Vhl gene inactivation induces cardiac HIF-dependent erythropoietin gene expression.
Volume: 6
Issue: 7
Pages: e22589
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Publication
25788526 | J:252077
First Author: Lehmann H
Year: 2015
Journal: J Am Soc Nephrol
Title: Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.
Volume: 26
Issue: 11
Pages: 2778-88
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Publication
24362914 | J:209063
First Author: Hell MP
Year: 2014
Journal: Cancer Res
Title: Tumor suppressor VHL functions in the control of mitotic fidelity.
Volume: 74
Issue: 9
Pages: 2422-31
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Publication
29229903 | J:254910
First Author: Espana-Agusti J
Year: 2017
Journal: Nat Commun
Title: Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis.
Volume: 8
Issue: 1
Pages: 2026
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Publication
30463876 | J:269772
First Author: Zhang W
Year: 2018
Journal: J Exp Med
Title: The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
Volume: 215
Issue: 12
Pages: 3180-3193
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Publication
30172741 | J:267740
 
First Author: Loots GG
Year: 2018
Journal: Bone
Title: Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects.
Volume: 116
Pages: 307-314
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Publication
22299048 | J:184217
First Author: Schietke RE
Year: 2012
Journal: PLoS One
Title: Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.
Volume: 7
Issue: 1
Pages: e31034
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Publication
19252526 | J:157369
First Author: Lee CM
Year: 2009
Journal: Oncogene
Title: VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo.
Volume: 28
Issue: 14
Pages: 1694-705
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Publication
15908240 | J:101112
First Author: Haase VH
Year: 2005
Journal: Semin Cell Dev Biol
Title: The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.
Volume: 16
Issue: 4-5
Pages: 564-74
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Publication
18219317 | J:147322
First Author: Kapitsinou PP
Year: 2008
Journal: Cell Death Differ
Title: The VHL tumor suppressor and HIF: insights from genetic studies in mice.
Volume: 15
Issue: 4
Pages: 650-9
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Publication
31123085 | J:280051
First Author: Zhu Y
Year: 2019
Journal: J Exp Med
Title: The E3 ligase VHL promotes follicular helper T cell differentiation via glycolytic-epigenetic control.
Volume: 216
Issue: 7
Pages: 1664-1681
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Publication
28574654 | J:276662
First Author: Wang Y
Year: 2017
Journal: Mol Carcinog
Title: Neuroprotective effects respond to cerebral ischemia without susceptibility to HB-tumorigenesis in VHL heterozygous knockout mice.
Volume: 56
Issue: 10
Pages: 2342-2351
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Publication
18297059 | J:145670
First Author: Young AP
Year: 2008
Journal: Nat Cell Biol
Title: VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.
Volume: 10
Issue: 3
Pages: 361-9
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Publication
20679489 | J:164903
First Author: Welford SM
Year: 2010
Journal: Mol Cell Biol
Title: Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress.
Volume: 30
Issue: 19
Pages: 4595-603
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Publication
14604887 | J:88492
First Author: Kleymenova E
Year: 2004
Journal: Carcinogenesis
Title: Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.
Volume: 25
Issue: 3
Pages: 309-15
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Publication
19340311 | J:148174
First Author: Shen HC
Year: 2009
Journal: PLoS One
Title: Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
Volume: 4
Issue: 4
Pages: e4897
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Publication
16652107 | J:110518
First Author: Hong SB
Year: 2006
Journal: Lab Invest
Title: Vascular defects and liver damage by the acute inactivation of the VHL gene during mouse embryogenesis.
Volume: 86
Issue: 7
Pages: 664-75
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Publication
26084024 | J:229111
First Author: Lee JH
Year: 2015
Journal: Immunity
Title: E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
Volume: 42
Issue: 6
Pages: 1062-74
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Publication
23606570 | J:231875
First Author: Albers J
Year: 2013
Journal: EMBO Mol Med
Title: Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.
Volume: 5
Issue: 6
Pages: 949-64
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Publication
23797537 | J:318988
First Author: Jiang X
Year: 2013
Journal: J Mol Med (Berl)
Title: Tie2-dependent VHL knockdown promotes airway microvascular regeneration and attenuates invasive growth of Aspergillus fumigatus.
Volume: 91
Issue: 9
Pages: 1081-93
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Publication
39040069 | J:352089
First Author: Grammer C
Year: 2024
Journal: iScience
Title: Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development.
Volume: 27
Issue: 7
Pages: 110258
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Publication
36204648 | J:360031
 
First Author: Ford CA
Year: 2022
Journal: Front Cell Infect Microbiol
Title: Loss of Vhl alters trabecular bone loss during S. aureus osteomyelitis in a cell-specific manner.
Volume: 12
Pages: 985467
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Publication
25359211 | J:216761
First Author: Wang SS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Bap1 is essential for kidney function and cooperates with Vhl in renal tumorigenesis.
Volume: 111
Issue: 46
Pages: 16538-43
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Gene
741715 | VHLL
Type: gene
Organism: chimpanzee
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Gene
100428982 | VHLL
Type: gene
Organism: macaque, rhesus
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Publication
16061637 | J:100777
First Author: Zanesi N
Year: 2005
Journal: Cancer Res
Title: Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency.
Volume: 65
Issue: 15
Pages: 6576-82
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Publication
20382704 | J:160375
First Author: Seagroves TN
Year: 2010
Journal: Am J Pathol
Title: VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.
Volume: 176
Issue: 5
Pages: 2269-82
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Publication
14500363 | J:85513
First Author: Ma W
Year: 2003
Journal: Cancer Res
Title: Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.
Volume: 63
Issue: 17
Pages: 5320-8
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Publication
38502859 | J:360208
First Author: Kurlekar S
Year: 2024
Journal: Cancer Res
Title: Oncogenic Cell Tagging and Single-Cell Transcriptomics Reveal Cell Type-Specific and Time-Resolved Responses to Vhl Inactivation in the Kidney.
Volume: 84
Issue: 11
Pages: 1799-1816
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Publication
18957870 | J:155367
First Author: Iguchi M
Year: 2008
Journal: Nephron Exp Nephrol
Title: Acute inactivation of the VHL gene contributes to protective effects of ischemic preconditioning in the mouse kidney.
Volume: 110
Issue: 3
Pages: e82-90
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Publication
29452935 | J:272363
First Author: Li Q
Year: 2018
Journal: Immunity
Title: E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Volume: 48
Issue: 2
Pages: 258-270.e5
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Publication
16977322 | J:144666
First Author: Kim WY
Year: 2006
Journal: EMBO J
Title: Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo.
Volume: 25
Issue: 19
Pages: 4650-62
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Publication
21242957 | J:170625
First Author: Choi D
Year: 2011
Journal: Lab Invest
Title: Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice.
Volume: 91
Issue: 4
Pages: 527-38
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Publication
23874892 | J:204393
First Author: Kurabayashi A
Year: 2013
Journal: PLoS One
Title: Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor.
Volume: 8
Issue: 7
Pages: e69139
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Publication
29431735 | J:260792
First Author: Dirckx N
Year: 2018
Journal: J Clin Invest
Title: Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism.
Volume: 128
Issue: 3
Pages: 1087-1105
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Publication
24972088 | J:214967
First Author: Mangiavini L
Year: 2014
Journal: Dev Biol
Title: Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
Volume: 393
Issue: 1
Pages: 124-36
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Publication
23999831 | J:233243
First Author: Weng T
Year: 2014
Journal: J Bone Miner Res
Title: Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.
Volume: 29
Issue: 4
Pages: 820-9
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Publication
28533271 | J:243202
First Author: Kuo CY
Year: 2017
Journal: Cancer Res
Title: VHL Inactivation in Precancerous Kidney Cells Induces an Inflammatory Response via ER Stress-Activated IRE1α Signaling.
Volume: 77
Issue: 13
Pages: 3406-3416
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Gene
481089 | VBP1
Type: gene
Organism: dog, domestic
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Gene
681825 | Vbp1
Type: gene
Organism: rat
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Gene
508727 | VBP1
Type: gene
Organism: cattle
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Gene
422355 | VBP1
Type: gene
Organism: chicken
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Gene
107971250 | VBP1
Type: gene
Organism: chimpanzee
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Gene
114669754 | VBP1
Type: gene
Organism: macaque, rhesus
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Publication
28765116 | J:243261
First Author: Leung JY
Year: 2017
Journal: Cancer Discov
Title: Bap1 and Pbrm1: Determinants of Tumor Grade and mTOR Activation in VHL-Deficient Mouse Models of Renal Cell Carcinoma.
Volume: 7
Issue: 8
Pages: 802-804
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Publication
7493907 | J:29955
First Author: Kikuchi Y
Year: 1995
Journal: Jpn J Cancer Res
Title: Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas.
Volume: 86
Issue: 10
Pages: 905-9
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Publication
21685897 | J:173530
First Author: Russell RC
Year: 2011
Journal: Nat Med
Title: Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia.
Volume: 17
Issue: 7
Pages: 845-53
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Publication
15824109 | J:101143
First Author: Lolkema MP
Year: 2005
Journal: J Biol Chem
Title: Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
Volume: 280
Issue: 23
Pages: 22205-11
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Publication
30110631 | J:271109
First Author: Izquierdo HM
Year: 2018
Journal: Cell Rep
Title: Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function.
Volume: 24
Issue: 7
Pages: 1738-1746
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Publication
28329682 | J:250939
First Author: Nargund AM
Year: 2017
Journal: Cell Rep
Title: The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma.
Volume: 18
Issue: 12
Pages: 2893-2906
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Publication
9256442 | J:42486
First Author: Gnarra JR
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
Volume: 94
Issue: 17
Pages: 9102-7
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Publication
25806791 | J:229265
First Author: Zuo GL
Year: 2015
Journal: PLoS One
Title: Activation of HIFa pathway in mature osteoblasts disrupts the integrity of the osteocyte/canalicular network.
Volume: 10
Issue: 3
Pages: e0121266
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Publication
20804974 | J:164436
First Author: Takubo K
Year: 2010
Journal: Cell Stem Cell
Title: Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.
Volume: 7
Issue: 3
Pages: 391-402
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Publication
18497742 | J:137073
First Author: Frew IJ
Year: 2008
Journal: EMBO J
Title: pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Volume: 27
Issue: 12
Pages: 1747-57
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Publication
25385837 | J:229209
First Author: Macías D
Year: 2014
Journal: EMBO Mol Med
Title: Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.
Volume: 6
Issue: 12
Pages: 1577-92
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Publication
7850784 | J:22926
First Author: Gao J
Year: 1995
Journal: Cancer Res
Title: Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential organization of the human von Hippel-Lindau disease gene.
Volume: 55
Issue: 4
Pages: 743-7
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Publication
11171994 | J:67505
First Author: Haase VH
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
Volume: 98
Issue: 4
Pages: 1583-8
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Publication
37626062 | J:339945
First Author: Kunke M
Year: 2023
Journal: Cell Death Dis
Title: Targeted deletion of von-Hippel-Lindau in the proximal tubule conditions the kidney against early diabetic kidney disease.
Volume: 14
Issue: 8
Pages: 562
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Publication
19033400 | J:146940
First Author: Puri S
Year: 2009
Journal: Diabetes
Title: A role for von Hippel-Lindau protein in pancreatic beta-cell function.
Volume: 58
Issue: 2
Pages: 433-41
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Publication
32690659 | J:300673
First Author: Chitrakar A
Year: 2020
Journal: J Immunol
Title: E3 Ubiquitin Ligase Von Hippel-Lindau Protein Promotes Th17 Differentiation.
Volume: 205
Issue: 4
Pages: 1009-1023
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Publication
27491826 | J:254095
 
First Author: Johansson E
Year: 2016
Journal: Sci Rep
Title: Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.
Volume: 6
Pages: 30739
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Publication
20516215 | J:162786
First Author: Hsouna A
Year: 2010
Journal: Mol Cell Biol
Title: Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis.
Volume: 30
Issue: 15
Pages: 3779-94
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Publication
29301791 | J:261894
First Author: Wang H
Year: 2018
Journal: Cancer Res
Title: Deletion of the von Hippel-Lindau Gene in Hemangioblasts Causes Hemangioblastoma-like Lesions in Murine Retina.
Volume: 78
Issue: 5
Pages: 1266-1274
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Publication
21925138 | J:177371
First Author: Theilig F
Year: 2011
Journal: Am J Pathol
Title: Tubular deficiency of von Hippel-Lindau attenuates renal disease progression in anti-GBM glomerulonephritis.
Volume: 179
Issue: 5
Pages: 2177-88
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Publication
17609290 | J:143007
First Author: Brukamp K
Year: 2007
Journal: Am J Physiol Renal Physiol
Title: Hypoxia and podocyte-specific Vhlh deletion confer risk of glomerular disease.
Volume: 293
Issue: 4
Pages: F1397-407
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Publication
24491803 | J:209149
First Author: Hell MP
Year: 2014
Journal: Cancer Res
Title: miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation.
Volume: 74
Issue: 9
Pages: 2432-43
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Publication
23541568 | J:198361
First Author: Frew IJ
Year: 2013
Journal: Eur J Cancer
Title: Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics.
Volume: 49
Issue: 10
Pages: 2433-40
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Publication
18559510 | J:138899
First Author: Champion KJ
Year: 2008
Journal: Cancer Res
Title: Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling.
Volume: 68
Issue: 12
Pages: 4649-57
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Publication
37833251 | J:344096
First Author: Hao W
Year: 2023
Journal: Cell Death Dis
Title: Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease.
Volume: 14
Issue: 10
Pages: 680
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Publication
12114475 | J:78029
First Author: Zatyka M
Year: 2002
Journal: J Med Genet
Title: Genetic and functional analysis of the von Hippel-Lindau (VHL) tumour suppressor gene promoter.
Volume: 39
Issue: 7
Pages: 463-72
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Publication
12628185 | J:107682
First Author: Cramer T
Year: 2003
Journal: Cell
Title: HIF-1alpha is essential for myeloid cell-mediated inflammation.
Volume: 112
Issue: 5
Pages: 645-57
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Publication
35532553 | J:332040
 
First Author: Han J
Year: 2022
Journal: J Exp Med
Title: Hypoxia induces adrenomedullin from lung epithelia, stimulating ILC2 inflammation and immunity.
Volume: 219
Issue: 6
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First Author: Schley G
Year: 2011
Journal: J Am Soc Nephrol
Title: Hypoxia-inducible transcription factors stabilization in the thick ascending limb protects against ischemic acute kidney injury.
Volume: 22
Issue: 11
Pages: 2004-15
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Publication
32792353 | J:299106
First Author: Ding X
Year: 2020
Journal: Genes Dev
Title: The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation.
Volume: 34
Issue: 17-18
Pages: 1177-1189
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Publication
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First Author: Espana-Agusti J
Year: 2016
Journal: PLoS One
Title: Generation and Characterisation of a Pax8-CreERT2 Transgenic Line and a Slc22a6-CreERT2 Knock-In Line for Inducible and Specific Genetic Manipulation of Renal Tubular Epithelial Cells.
Volume: 11
Issue: 2
Pages: e0148055
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Publication
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First Author: van Asselt SJ
Year: 2013
Journal: Cilia
Title: Pancreatic cyst development: insights from von Hippel-Lindau disease.
Volume: 2
Issue: 1
Pages: 3
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First Author: Yokoe S
Year: 2017
Journal: Int J Mol Sci
Title: Phospholamban Is Downregulated by pVHL-Mediated Degradation through Oxidative Stress in Failing Heart.
Volume: 18
Issue: 11
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