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Search results 1 to 100 out of 182 for Vkorc1l1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
154807 | VKORC1L1
Type: gene
Organism: human
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Gene
549523 | vkorc1l1
Type: gene
Organism: frog, western clawed
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Gene
399684 | Vkorc1l1
Type: gene
Organism: rat
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Gene
606915 | VKORC1L1
Type: gene
Organism: dog, domestic
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Gene
472396 | VKORC1L1
Type: gene
Organism: chimpanzee
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Gene
506318 | VKORC1L1
Type: gene
Organism: cattle
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Gene
408253 | VKORC1L1
Type: gene
Organism: chicken
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Gene
553717 | vkorc1l1
Type: gene
Organism: zebrafish
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Gene
697591 | VKORC1L1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1916818 | Vkorc1l1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
29321368 | J:262230
 
First Author: Lacombe J
Year: 2018
Journal: JCI Insight
Title: VKOR paralog VKORC1L1 supports vitamin K-dependent protein carboxylation in vivo.
Volume: 3
Issue: 1
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Publication
23928358 | J:207800
First Author: Hammed A
Year: 2013
Journal: J Biol Chem
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Volume: 288
Issue: 40
Pages: 28733-42
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Protein Coding Gene
MGP_CAROLIEiJ_G0027792 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0030136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0030104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0030037 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0030114 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029830 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1916818 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030567 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0029240 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029800 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029951 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029906 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0030039 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030607 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028954 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0029313 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0020602 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028790 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6198651
Age: embryonic day 16.5
Image: 3
Specimen Label: e16.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:6198651
Age: embryonic day 18.5
Image: 3
Specimen Label: e18.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6198651
Age: postnatal day 0
Image: 3
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198651
Age: postnatal day 7
Image: 3
Specimen Label: P7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198651
Age: postnatal day 15
Image: 3
Specimen Label: P15
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:6198655
Age: embryonic day 14.5
Image: 3
Specimen Label: e14.5
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6198655
Age: embryonic day 16.5
Image: 3
Specimen Label: e16.5
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:6198655
Age: embryonic day 18.5
Image: 3
Specimen Label: e18.5
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6198655
Age: postnatal day 0
Image: 3
Specimen Label: P0
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198655
Age: postnatal day 7
Image: 3
Specimen Label: P7
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:6198618
Assay Type: RT-PCR
Annotation Date: 2018-09-19
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198655
Age: postnatal day 15
Image: 3
Specimen Label: P15
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:6198661
Age: embryonic day 16.5
Image: 3
Specimen Label: e16.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:6198661
Age: embryonic day 18.5
Image: 3
Specimen Label: e18.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:6198661
Age: postnatal day 0
Image: 3
Specimen Label: P0
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198661
Age: postnatal day 7
Image: 3
Specimen Label: P7
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:6198616
Assay Type: Western blot
Annotation Date: 2018-09-19
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:6198661
Age: postnatal day 15
Image: 3
Specimen Label: P15
Detected: true
Specimen Num: 5
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Publication
37171959 | J:337581
First Author: Lacombe J
Year: 2023
Journal: Cell Rep
Title: Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells.
Volume: 42
Issue: 5
Pages: 112500
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Publication
14765194 | J:88164
First Author: Rost S
Year: 2004
Journal: Nature
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Volume: 427
Issue: 6974
Pages: 537-41
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Publication
25753038 | J:264734
First Author: Ferron M
Year: 2015
Journal: J Cell Biol
Title: GGCX and VKORC1 inhibit osteocalcin endocrine functions.
Volume: 208
Issue: 6
Pages: 761-76
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(ApoE-Vkorc1l1)73Mf | MGI:7495947
Name: transgene insertion 73, Mathieu Ferron
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
15879509 | J:101681
First Author: Pelz HJ
Year: 2005
Journal: Genetics
Title: The genetic basis of resistance to anticoagulants in rodents.
Volume: 170
Issue: 4
Pages: 1839-47
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Protein
A0A7T0LZ52
Organism: Mus musculus/domesticus
Length: 36  
Fragment?: true
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Protein
A0A7T8CZC8
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
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Protein
Q0VGU5
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Publication
16677080 | -
First Author: Oldenburg J
Year: 2006
Journal: Antioxid Redox Signal
Title: Vitamin K epoxide reductase complex subunit 1 (VKORC1): the key protein of the vitamin K cycle.
Volume: 8
Issue: 3-4
Pages: 347-53
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Publication
16270630 | -
First Author: Rost S
Year: 2005
Journal: Thromb Haemost
Title: Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin.
Volume: 94
Issue: 4
Pages: 780-6
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Publication
30050002 | -
 
First Author: Lacombe J
Year: 2018
Journal: Nutrients
Title: VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues.
Volume: 10
Issue: 8
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Publication
24532791 | -
First Author: Tie JK
Year: 2014
Journal: J Biol Chem
Title: Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
Volume: 289
Issue: 13
Pages: 9396-407
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Protein Domain
IPR042406 | VKORC1/VKORC1L1
Type: Family
Description: This entry represents the vitamin K epoxide reductase complex subunit VKORC1 and VKORC1L1 mostly from animals.VKORC1 is an integral membrane protein that catalyzes the reduction of vitamin K 2,3-epoxide and vitamin K to vitamin K hydroquinone, an essential co-factor subsequently used in the γ-carboxylation of glutamic acid residues in blood coagulation enzymes [, ]. All homologues of VKOR contain an active site CXXC motif, which is switched between reduced and disulfide-bonded states during the reaction cycle []. Warfarin, a widely used oral anticoagulant used in medicine as well as rodenticides, inhibits the activity of VKOR, resulting in decreased levels of reduced vitamin K, which is required for the function of several clotting factors []. However, anticoagulation effect of warfarin is significantly associated with polymorphism of certain genes, including VKORC1. Interestingly, in rodents, an adaptive trait appears to have evolved convergently by selection on new or standing genetic polymorphisms in VKORC1 as well as by adaptive introgressive hybridization between species, likely brought about by human-mediated dispersal []. VKORC1L1, a paralogue of VKORC1, is a vitamin K oxidoreductase, which can support γ-carboxylation in vivo [, ].
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Protein
A0A0J9YUN6
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
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Protein
Q6TEK5
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
Q9CRC0
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
A0A7T0LYK8
Organism: Mus musculus/domesticus
Length: 70  
Fragment?: true
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Protein
A0A7T8D0F0
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
A0A7T0LYF6
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: false
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Protein
A0A6G7NPC0
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
G3CE67
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Protein
A0A7T0LZK8
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A0A7T8I0N9
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein
A0A7T8CZH7
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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