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Search results 1 to 100 out of 834 for Vldlr

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
7436 | VLDLR
Type: gene
Organism: human
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Gene
282123 | VLDLR
Type: gene
Organism: cattle
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Gene
396154 | VLDLR
Type: gene
Organism: chicken
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Gene
393897 | vldlr
Type: gene
Organism: zebrafish
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Gene
574284 | VLDLR
Type: gene
Organism: macaque, rhesus
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Gene
733485 | vldlr
Type: gene
Organism: frog, western clawed
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Gene
key_24712 | VLDLR
Type: gene
Organism: rabbit, European
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Gene
25696 | Vldlr
Type: gene
Organism: rat
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Gene
476336 | VLDLR
Type: gene
Organism: dog, domestic
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Gene
464967 | VLDLR
Type: gene
Organism: chimpanzee
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Protein Domain
IPR032931 | VLDLR
Type: Family
Description: Very low-density lipoprotein receptor (VLDLR) mediates the binding and uptake of apoE-containing lipoproteins, such as VLDL and beta-VLDL []. It prevents the migration of retinal vascular endothelial cells into the photoreceptor cell layer and subretinal space []and mediates an anti-angiogenic signal in the retina []. It is involved in adipose tissue inflammation and mediates VLDL-induced lipid accumulation and induction of inflammation and ER stress in adipocytes and macrophages [].
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Protein Coding Gene
MGI:98935 | Vldlr
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
24058663 | J:207341
First Author: Xia CH
Year: 2013
Journal: PLoS One
Title: Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization.
Volume: 8
Issue: 9
Pages: e75186
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Gene
401491 | VLDLR-AS1
Type: gene
Organism: human
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Publication
24293365 | J:207175
First Author: Nguyen A
Year: 2014
Journal: J Biol Chem
Title: Very low density lipoprotein receptor (VLDLR) expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction.
Volume: 289
Issue: 3
Pages: 1688-703
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Publication
18936153 | J:146685
First Author: Jiang A
Year: 2009
Journal: Invest Ophthalmol Vis Sci
Title: Loss of VLDL receptor activates retinal vascular endothelial cells and promotes angiogenesis.
Volume: 50
Issue: 2
Pages: 844-50
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Protein
P98156
Organism: Mus musculus/domesticus
Length: 873  
Fragment?: false
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Publication
29057873 | J:256795
First Author: Shin KC
Year: 2017
Journal: Nat Commun
Title: Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation.
Volume: 8
Issue: 1
Pages: 1087
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Publication
21757581 | J:176337
First Author: Xia CH
Year: 2011
Journal: Invest Ophthalmol Vis Sci
Title: The role of Vldlr in intraretinal angiogenesis in mice.
Volume: 52
Issue: 9
Pages: 6572-9
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Publication
28591574 | J:254510
First Author: Huynh H
Year: 2017
Journal: Cell Rep
Title: mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss.
Volume: 19
Issue: 10
Pages: 2014-2025
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Publication
17685481 | J:124181
First Author: Zhao S
Year: 2007
Journal: Dev Dyn
Title: Selective expression of LDLR and VLDLR in myelinating oligodendrocytes.
Volume: 236
Issue: 9
Pages: 2708-12
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Publication
22115756 | J:178996
First Author: Rebustini IT
Year: 2012
Journal: Development
Title: miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis.
Volume: 139
Issue: 1
Pages: 191-202
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Publication
17261317 | J:124495
First Author: Barr AM
Year: 2007
Journal: Neuropharmacology
Title: The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice.
Volume: 52
Issue: 4
Pages: 1114-23
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Publication
17913789 | J:126335
First Author: Hack I
Year: 2007
Journal: Development
Title: Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons.
Volume: 134
Issue: 21
Pages: 3883-91
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Publication
27184477 | J:256645
 
First Author: Fraley ER
Year: 2016
Journal: Sci Rep
Title: Mice with Dab1 or Vldlr insufficiency exhibit abnormal neonatal vocalization patterns.
Volume: 6
Pages: 25807
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Publication
23758727 | J:199170
 
First Author: Su J
Year: 2013
Journal: Neural Dev
Title: Contributions of VLDLR and LRP8 in the establishment of retinogeniculate projections.
Volume: 8
Pages: 11
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Publication
27711217 | J:301943
First Author: Augustin M
Year: 2016
Journal: PLoS One
Title: Multi-Functional OCT Enables Longitudinal Study of Retinal Changes in a VLDLR Knockout Mouse Model.
Volume: 11
Issue: 10
Pages: e0164419
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Publication
32540847 | J:291477
 
First Author: Hirota Y
Year: 2020
Journal: Development
Title: VLDLR is not essential for reelin-induced neuronal aggregation but suppresses neuronal invasion into the marginal zone.
Volume: 147
Issue: 12
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Protein
F6RKS4
Organism: Mus musculus/domesticus
Length: 258  
Fragment?: true
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Protein
Q3UVX6
Organism: Mus musculus/domesticus
Length: 721  
Fragment?: false
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Protein
F8WIN7
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
E9Q643
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
F8WGI9
Organism: Mus musculus/domesticus
Length: 804  
Fragment?: false
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Protein
Q91YY0
Organism: Mus musculus/domesticus
Length: 845  
Fragment?: false
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Publication
12870663 | -
First Author: Takahashi S
Year: 2003
Journal: Mol Cell Biochem
Title: The very low density lipoprotein (VLDL) receptor--a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues.
Volume: 248
Issue: 1-2
Pages: 121-7
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Publication
21273557 | J:184166
First Author: Roubtsova A
Year: 2011
Journal: Arterioscler Thromb Vasc Biol
Title: Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue.
Volume: 31
Issue: 4
Pages: 785-91
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Publication
22429478 | J:316812
 
First Author: Dumanis SB
Year: 2012
Journal: Mol Neurodegener
Title: FE65 as a link between VLDLR and APP to regulate their trafficking and processing.
Volume: 7
Pages: 9
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Publication
25308109 | J:219839
First Author: Hirota Y
Year: 2015
Journal: J Comp Neurol
Title: Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex.
Volume: 523
Issue: 3
Pages: 463-78
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Publication
22096238 | J:181802
First Author: Yakovlev S
Year: 2012
Journal: Blood
Title: Identification of VLDLR as a novel endothelial cell receptor for fibrin that modulates fibrin-dependent transendothelial migration of leukocytes.
Volume: 119
Issue: 2
Pages: 637-44
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Publication
21364932 | J:171070
First Author: Zhou X
Year: 2011
Journal: PLoS One
Title: Nanoceria inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse.
Volume: 6
Issue: 2
Pages: e16733
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Publication
18301736 | J:132885
First Author: Larouche M
Year: 2008
Journal: PLoS One
Title: The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum.
Volume: 3
Issue: 2
Pages: e1653
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Publication
26177550 | J:238531
First Author: Johnson V
Year: 2015
Journal: PLoS One
Title: Neurite Mistargeting and Inverse Order of Intraretinal Vascular Plexus Formation Precede Subretinal Vascularization in Vldlr Mutant Mice.
Volume: 10
Issue: 7
Pages: e0132013
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Publication
19393635 | J:157221
 
First Author: Sakai K
Year: 2009
Journal: Brain Res
Title: A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins.
Volume: 1276
Pages: 11-21
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Publication
23976984 | J:205842
First Author: Sharaf A
Year: 2013
Journal: PLoS One
Title: ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.
Volume: 8
Issue: 8
Pages: e71091
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Publication
18172119 | J:132497
First Author: Hu W
Year: 2008
Journal: Invest Ophthalmol Vis Sci
Title: Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation.
Volume: 49
Issue: 1
Pages: 407-15
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Publication
19572151 | J:152242
First Author: Schnaufer C
Year: 2009
Journal: Cell Tissue Res
Title: Outgrowing olfactory axons contain the Reelin receptor VLDLR and navigate through the Reelin-rich cribriform mesenchyme.
Volume: 337
Issue: 3
Pages: 393-406
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Publication
23978600 | J:210396
 
First Author: Kyosseva SV
Year: 2013
Journal: Exp Eye Res
Title: Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice.
Volume: 116
Pages: 63-74
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Publication
12586425 | J:82121
First Author: Luque JM
Year: 2003
Journal: Brain Res Dev Brain Res
Title: Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development.
Volume: 140
Issue: 2
Pages: 195-203
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HT Experiment
E-GEOD-78831 | Vldlr KO vs Jax WT Array
Series Id: GSE78831
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
- | J:264645
     
First Author: Ufret-Vincenty R
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for spotty.
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Publication
10380922 | J:55691
First Author: Trommsdorff M
Year: 1999
Journal: Cell
Title: Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.
Volume: 97
Issue: 6
Pages: 689-701
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Publication
15327526 | J:109394
First Author: Bovenschen N
Year: 2004
Journal: Br J Haematol
Title: Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice.
Volume: 126
Issue: 5
Pages: 722-5
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Publication
33850206 | J:313770
First Author: Oshio Y
Year: 2021
Journal: Sci Rep
Title: Very low-density lipoprotein receptor increases in a liver-specific manner due to protein deficiency but does not affect fatty liver in mice.
Volume: 11
Issue: 1
Pages: 8003
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Publication
17562991 | J:128315
First Author: Li C
Year: 2007
Journal: Arch Ophthalmol
Title: Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation.
Volume: 125
Issue: 6
Pages: 795-803
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Publication
12972764 | J:114757
First Author: Heckenlively JR
Year: 2003
Journal: Retina
Title: Mouse model of subretinal neovascularization with choroidal anastomosis.
Volume: 23
Issue: 4
Pages: 518-22
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Publication
15145981 | J:277419
First Author: Goudriaan JR
Year: 2004
Journal: J Lipid Res
Title: The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis.
Volume: 45
Issue: 8
Pages: 1475-81
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Publication
17890782 | J:128338
First Author: Chen Y
Year: 2007
Journal: J Biol Chem
Title: Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization.
Volume: 282
Issue: 47
Pages: 34420-8
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Publication
24733846 | J:288740
First Author: Fredriksson K
Year: 2014
Journal: J Immunol
Title: The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses.
Volume: 192
Issue: 10
Pages: 4497-509
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Publication
21670500 | J:175645
First Author: Perman JC
Year: 2011
Journal: J Clin Invest
Title: The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction.
Volume: 121
Issue: 7
Pages: 2625-40
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Publication
21924248 | J:178736
First Author: Tao H
Year: 2011
Journal: Biochem Pharmacol
Title: Very low density lipoprotein receptor promotes adipocyte differentiation and mediates the proadipogenic effect of peroxisome proliferator-activated receptor gamma agonists.
Volume: 82
Issue: 12
Pages: 1950-62
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Publication
10571241 | J:212819
First Author: Hiesberger T
Year: 1999
Journal: Neuron
Title: Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.
Volume: 24
Issue: 2
Pages: 481-9
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Publication
7925422 | J:20839
First Author: Oka K
Year: 1994
Journal: Eur J Biochem
Title: Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor.
Volume: 224
Issue: 3
Pages: 975-82
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Publication
18946489 | J:143787
First Author: Blake SM
Year: 2008
Journal: EMBO J
Title: Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration.
Volume: 27
Issue: 22
Pages: 3069-80
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Publication
12687696 | J:83151
First Author: Weiss KH
Year: 2003
Journal: J Comp Neurol
Title: Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice.
Volume: 460
Issue: 1
Pages: 56-65
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Publication
31233254 | J:291316
First Author: Shao Y
Year: 2019
Journal: Stem Cells
Title: Canonical Wnt Signaling Promotes Neovascularization Through Determination of Endothelial Progenitor Cell Fate via Metabolic Profile Regulation.
Volume: 37
Issue: 10
Pages: 1331-1343
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Publication
11557677 | J:102939
First Author: Goudriaan JR
Year: 2001
Journal: Arterioscler Thromb Vasc Biol
Title: Protection from obesity in mice lacking the VLDL receptor.
Volume: 21
Issue: 9
Pages: 1488-93
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Publication
11790777 | J:75452
First Author: Yagyu H
Year: 2002
Journal: J Biol Chem
Title: Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency.
Volume: 277
Issue: 12
Pages: 10037-43
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Publication
18375436 | J:138231
First Author: Qiao L
Year: 2008
Journal: Diabetes
Title: Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism.
Volume: 57
Issue: 7
Pages: 1824-33
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Publication
17330141 | J:129338
First Author: Zhang G
Year: 2007
Journal: PLoS One
Title: The Pafah1b complex interacts with the reelin receptor VLDLR.
Volume: 2
Issue: 2
Pages: e252
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Publication
14578885 | J:86398
First Author: Assadi AH
Year: 2003
Journal: Nat Genet
Title: Interaction of reelin signaling and Lis1 in brain development.
Volume: 35
Issue: 3
Pages: 270-6
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Publication
18675252 | J:140041
First Author: Shan L
Year: 2008
Journal: Biochem Biophys Res Commun
Title: PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.
Volume: 375
Issue: 1
Pages: 69-73
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Publication
34509473 | J:340540
First Author: Ma X
Year: 2021
Journal: J Biol Chem
Title: ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium.
Volume: 297
Issue: 4
Pages: 101185
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Publication
21976526 | J:177435
First Author: Trotter JH
Year: 2011
Journal: J Neurosci
Title: ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.
Volume: 31
Issue: 40
Pages: 14413-23
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Publication
23209795 | J:225068
First Author: Hellwig S
Year: 2012
Journal: PLoS One
Title: Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb.
Volume: 7
Issue: 11
Pages: e50646
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Publication
19861583 | J:170136
First Author: Tao H
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: Peroxisome proliferator-activated receptor-gamma regulates the expression and function of very-low-density lipoprotein receptor.
Volume: 298
Issue: 1
Pages: E68-79
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Publication
11108739 | J:66431
First Author: Tacken PJ
Year: 2000
Journal: J Lipid Res
Title: LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice.
Volume: 41
Issue: 12
Pages: 2055-62
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Publication
27528615 | J:236304
First Author: Chen Q
Year: 2016
Journal: Mol Cell Biol
Title: Functional Differences of Very-Low-Density Lipoprotein Receptor Splice Variants in Regulating Wnt Signaling.
Volume: 36
Issue: 20
Pages: 2645-54
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Publication
17494763 | J:121846
First Author: Andrade N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin.
Volume: 104
Issue: 20
Pages: 8508-13
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Publication
18279306 | J:132269
First Author: Akopians AL
Year: 2008
Journal: Eur J Neurosci
Title: Contribution of the Reelin signaling pathways to nociceptive processing.
Volume: 27
Issue: 3
Pages: 523-37
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Publication
28484035 | J:242292
First Author: Jakob B
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus.
Volume: 114
Issue: 21
Pages: 5533-5538
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Publication
25644714 | J:234584
First Author: DiBattista AM
Year: 2015
Journal: Biochim Biophys Acta
Title: Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.
Volume: 1853
Issue: 5
Pages: 904-17
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Publication
14750162 | J:88816
First Author: Yip YP
Year: 2004
Journal: J Comp Neurol
Title: Components of the reelin signaling pathway are expressed in the spinal cord.
Volume: 470
Issue: 2
Pages: 210-9
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Publication
15548227 | J:101281
First Author: Perez-Garcia CG
Year: 2004
Journal: Eur J Neurosci
Title: Reelin receptors in developing laminated brain structures of mouse and human.
Volume: 20
Issue: 10
Pages: 2827-32
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Publication
28123028 | J:239151
First Author: Ha S
Year: 2017
Journal: J Neurosci
Title: C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus.
Volume: 37
Issue: 4
Pages: 960-971
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Publication
7774911 | J:22833
First Author: Pilz A
Year: 1995
Journal: Genomics
Title: Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.
Volume: 25
Issue: 1
Pages: 139-49
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Publication
10024503 | J:53607
 
First Author: Jong MC
Year: 1999
Journal: Biochem J
Title: Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor.
Volume: 338 ( Pt 2)
Pages: 281-7
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Publication
8636110 | J:32102
First Author: Kobayashi K
Year: 1996
Journal: J Biol Chem
Title: Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor.
Volume: 271
Issue: 12
Pages: 6852-60
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Publication
16478678 | J:110564
First Author: van der Hoogt CC
Year: 2006
Journal: Biochim Biophys Acta
Title: Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice.
Volume: 1761
Issue: 2
Pages: 213-20
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Publication
15249135 | J:91679
First Author: Herrick TM
Year: 2004
Journal: Brain Res Mol Brain Res
Title: High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons.
Volume: 126
Issue: 2
Pages: 121-8
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Publication
8013374 | J:19195
First Author: Gåfvels ME
Year: 1994
Journal: Endocrinology
Title: Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.
Volume: 135
Issue: 1
Pages: 387-94
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Publication
19033669 | J:144730
First Author: Deane R
Year: 2008
Journal: J Clin Invest
Title: apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain.
Volume: 118
Issue: 12
Pages: 4002-13
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Publication
32140075 | J:344756
First Author: Xiao X
Year: 2020
Journal: Int J Biol Sci
Title: ROBO4 deletion ameliorates PAF-mediated skin inflammation via regulating the mRNA translation efficiency of LPCAT1/LPCAT2 and the expression of PAF receptor.
Volume: 16
Issue: 6
Pages: 1086-1095
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Publication
33009002 | J:299731
First Author: Kohno T
Year: 2020
Journal: J Neurosci
Title: Reelin-Nrp1 Interaction Regulates Neocortical Dendrite Development in a Context-Specific Manner.
Volume: 40
Issue: 43
Pages: 8248-8261
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Publication
12526740 | J:109819
First Author: Bock HH
Year: 2003
Journal: Curr Biol
Title: Reelin activates SRC family tyrosine kinases in neurons.
Volume: 13
Issue: 1
Pages: 18-26
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Publication
25418135 | J:309447
First Author: Sharaf A
Year: 2015
Journal: Cell Tissue Res
Title: Localization of reelin signaling pathway components in murine midbrain and striatum.
Volume: 359
Issue: 2
Pages: 393-407
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Publication
10488949 | J:59491
First Author: Tiebel O
Year: 1999
Journal: Atherosclerosis
Title: Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation.
Volume: 145
Issue: 2
Pages: 239-51
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Publication
30127721 | J:310452
 
First Author: Dairaghi L
Year: 2018
Journal: Front Cell Neurosci
Title: Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.
Volume: 12
Pages: 228
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Publication
21460838 | J:171375
First Author: Sentürk A
Year: 2011
Journal: Nature
Title: Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Volume: 472
Issue: 7343
Pages: 356-60
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Protein Coding Gene
MGP_CAROLIEiJ_G0022843 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0025007 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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