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Search results 1 to 100 out of 384 for Vps35

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
55737 | VPS35
Type: gene
Organism: human
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Gene
549980 | vps35
Type: gene
Organism: frog, western clawed
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Gene
25479 | Vps35
Type: gene
Organism: rat
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Gene
475346 | VPS35
Type: gene
Organism: dog, domestic
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Gene
465139 | VPS35
Type: gene
Organism: chimpanzee
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Gene
521864 | VPS35
Type: gene
Organism: cattle
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Gene
415750 | VPS35
Type: gene
Organism: chicken
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Gene
561697 | vps35
Type: gene
Organism: zebrafish
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Gene
717394 | VPS35
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1890467 | Vps35
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR005378 | Vps35
Type: Family
Description: This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes.Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [, ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed of Vps26, Vps29 and Vps35 and is responsible for binding to and sorting protein cargo []. Mutations in the Vps35 gene have been linked to Parkinson's disease []. Structurally, VPS35 forms a horseshoe-shaped, right-handed, α-helical solenoid [].
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Publication
22105352 | J:178937
First Author: Wen L
Year: 2011
Journal: J Cell Biol
Title: VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.
Volume: 195
Issue: 5
Pages: 765-79
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Publication
23259059 | J:192876
First Author: Wang CL
Year: 2012
Journal: Biol Open
Title: VPS35 regulates developing mouse hippocampal neuronal morphogenesis by promoting retrograde trafficking of BACE1.
Volume: 1
Issue: 12
Pages: 1248-57
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Publication
30155515 | J:274797
 
First Author: Cataldi S
Year: 2018
Journal: NPJ Parkinsons Dis
Title: Altered dopamine release and monoamine transporters in Vps35 p.D620N knock-in mice.
Volume: 4
Pages: 27
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Publication
33257649 | J:329507
First Author: Chiu CC
Year: 2020
Journal: Cell Death Dis
Title: (D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model.
Volume: 11
Issue: 11
Pages: 1018
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Publication
25416282 | J:219408
First Author: Munsie LN
Year: 2015
Journal: Hum Mol Genet
Title: Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.
Volume: 24
Issue: 6
Pages: 1691-703
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Publication
23509071 | J:196686
First Author: Xia WF
Year: 2013
Journal: J Cell Biol
Title: Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling.
Volume: 200
Issue: 6
Pages: 821-37
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Publication
11112353 | J:66223
First Author: Zhang P
Year: 2000
Journal: Genomics
Title: Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21.
Volume: 70
Issue: 2
Pages: 253-7
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Publication
34530877 | J:313813
First Author: Kadgien CA
Year: 2021
Journal: Mol Brain
Title: Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Volume: 14
Issue: 1
Pages: 143
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Publication
28173004 | J:238647
First Author: Ishizu N
Year: 2016
Journal: Hum Mol Genet
Title: Impaired striatal dopamine release in homozygous Vps35 D620N knock-in mice.
Volume: 25
Issue: 20
Pages: 4507-4517
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Publication
29445238 | J:263203
First Author: Vazquez-Sanchez S
Year: 2018
Journal: Sci Rep
Title: VPS35 depletion does not impair presynaptic structure and function.
Volume: 8
Issue: 1
Pages: 2996
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Gene
100422055 | VPS35P1
Type: gene
Organism: human
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Publication
37542299 | J:341051
First Author: Chen X
Year: 2023
Journal: Mol Neurodegener
Title: VPS35 and α-Synuclein fail to interact to modulate neurodegeneration in rodent models of Parkinson's disease.
Volume: 18
Issue: 1
Pages: 51
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Publication
31771656 | J:292365
First Author: Ye SY
Year: 2019
Journal: J Neuroinflammation
Title: Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex.
Volume: 16
Issue: 1
Pages: 235
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Publication
35236374 | J:321997
First Author: Ren X
Year: 2022
Journal: J Neuroinflammation
Title: Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology.
Volume: 19
Issue: 1
Pages: 61
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Publication
33745227 | J:303283
First Author: Niu M
Year: 2021
Journal: Aging Cell
Title: VPS35 D620N knockin mice recapitulate cardinal features of Parkinson's disease.
Volume: 20
Issue: 5
Pages: e13347
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Publication
33261640 | J:303876
First Author: Vanan S
Year: 2020
Journal: Mol Brain
Title: Altered striatal dopamine levels in Parkinson's disease VPS35 D620N mutant transgenic aged mice.
Volume: 13
Issue: 1
Pages: 164
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Publication
34445101 | J:311515
 
First Author: Zhao Y
Year: 2021
Journal: Int J Mol Sci
Title: Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death.
Volume: 22
Issue: 16
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Publication
24512632 | J:280216
 
First Author: Liu W
Year: 2014
Journal: Mol Brain
Title: Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis.
Volume: 7
Pages: 10
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Publication
26321632 | J:264396
First Author: Tang FL
Year: 2015
Journal: Cell Rep
Title: VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.
Volume: 12
Issue: 10
Pages: 1631-43
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Publication
32291328 | J:288885
First Author: Wu KY
Year: 2020
Journal: J Neurosci
Title: Ependymal Vps35 Promotes Ependymal Cell Differentiation and Survival, Suppresses Microglial Activation, and Prevents Neonatal Hydrocephalus.
Volume: 40
Issue: 19
Pages: 3862-3879
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Publication
30842285 | J:273181
First Author: Chen X
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
Volume: 116
Issue: 12
Pages: 5765-5774
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Publication
25533483 | J:219342
First Author: Dhungel N
Year: 2015
Journal: Neuron
Title: Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein.
Volume: 85
Issue: 1
Pages: 76-87
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Publication
34704029 | J:320477
First Author: Sargent D
Year: 2021
Journal: Brain Commun
Title: Neuronal VPS35 deletion induces spinal cord motor neuron degeneration and early post-natal lethality.
Volume: 3
Issue: 3
Pages: fcab208
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Publication
17239604 | J:225408
First Author: George A
Year: 2007
Journal: Neurobiol Dis
Title: The vacuolar-ATPase inhibitor bafilomycin and mutant VPS35 inhibit canonical Wnt signaling.
Volume: 26
Issue: 1
Pages: 125-33
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Publication
27460146 | J:235288
 
First Author: Wang C
Year: 2016
Journal: Neurobiol Aging
Title: VPS35 regulates cell surface recycling and signaling of dopamine receptor D1.
Volume: 46
Pages: 22-31
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Publication
35367368 | J:324458
 
First Author: Roque M
Year: 2022
Journal: Mol Cell Neurosci
Title: VPS35 deficiency in the embryonic cortex leads to prenatal cell loss and abnormal development of axonal connectivity.
Volume: 120
Pages: 103726
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Publication
26203154 | J:225806
First Author: Tang FL
Year: 2015
Journal: J Neurosci
Title: VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease.
Volume: 35
Issue: 29
Pages: 10613-28
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Publication
29893854 | J:267014
First Author: Williams ET
Year: 2018
Journal: Hum Mol Genet
Title: Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.
Volume: 27
Issue: 18
Pages: 3189-3205
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Publication
33239387 | J:299250
 
First Author: Simoes S
Year: 2020
Journal: Sci Transl Med
Title: Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.
Volume: 12
Issue: 571
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Publication
37248224 | J:337066
First Author: Daly JL
Year: 2023
Journal: Nat Commun
Title: Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health.
Volume: 14
Issue: 1
Pages: 3086
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Protein
Q3TUV7
Organism: Mus musculus/domesticus
Length: 204  
Fragment?: true
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Publication
38091401 | J:349290
First Author: Pal P
Year: 2023
Journal: Sci Adv
Title: Parkinson's VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B.
Volume: 9
Issue: 50
Pages: eadj1205
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Publication
11598206 | -
First Author: Reddy JV
Year: 2001
Journal: Mol Biol Cell
Title: Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.
Volume: 12
Issue: 10
Pages: 3242-56
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Publication
17891154 | -
First Author: Hierro A
Year: 2007
Journal: Nature
Title: Functional architecture of the retromer cargo-recognition complex.
Volume: 449
Issue: 7165
Pages: 1063-7
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Publication
25937119 | -
First Author: Fuse A
Year: 2015
Journal: FEBS Lett
Title: VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.
Volume: 589
Issue: 13
Pages: 1430-6
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Publication
23148298 | -
First Author: Seaman MN
Year: 2012
Journal: J Cell Sci
Title: The retromer complex - endosomal protein recycling and beyond.
Volume: 125
Issue: Pt 20
Pages: 4693-702
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Protein
Q9EQH3
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Protein
Q3TJ43
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Protein
Q3UQJ1
Organism: Mus musculus/domesticus
Length: 730  
Fragment?: true
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Protein
Q3TKU6
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Protein
Q3TRJ1
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: false
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Publication
28934248 | J:246670
First Author: Liu W
Year: 2017
Journal: PLoS One
Title: Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.
Volume: 12
Issue: 9
Pages: e0184906
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Publication
26521016 | J:263408
First Author: Tian Y
Year: 2015
Journal: Mol Brain
Title: VPS35-deficiency results in an impaired AMPA receptor trafficking and decreased dendritic spine maturation.
Volume: 8
Issue: 1
Pages: 70
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Publication
24130821 | J:223191
First Author: de Groot RE
Year: 2013
Journal: PLoS One
Title: Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium.
Volume: 8
Issue: 10
Pages: e76971
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Publication
35045281 | J:327028
First Author: Qureshi YH
Year: 2022
Journal: Cell Rep
Title: The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease.
Volume: 38
Issue: 3
Pages: 110262
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Publication
18160348 | J:225406
First Author: Belenkaya TY
Year: 2008
Journal: Dev Cell
Title: The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network.
Volume: 14
Issue: 1
Pages: 120-31
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Publication
29853629 | J:263545
First Author: Appel JR
Year: 2018
Journal: J Neurosci
Title: Increased Microglial Activity, Impaired Adult Hippocampal Neurogenesis, and Depressive-like Behavior in Microglial VPS35-Depleted Mice.
Volume: 38
Issue: 26
Pages: 5949-5968
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Publication
27333042 | J:315573
 
First Author: Xiong L
Year: 2016
Journal: EBioMedicine
Title: Retromer in Osteoblasts Interacts With Protein Phosphatase 1 Regulator Subunit 14C, Terminates Parathyroid Hormone's Signaling, and Promotes Its Catabolic Response.
Volume: 9
Pages: 45-60
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Publication
29743203 | J:263679
First Author: Mir R
Year: 2018
Journal: Biochem J
Title: The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Volume: 475
Issue: 11
Pages: 1861-1883
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Publication
32631998 | J:294731
First Author: Nguyen APT
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Volume: 117
Issue: 29
Pages: 17296-17307
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Protein Coding Gene
MGP_CAROLIEiJ_G0031335 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0033898 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0033881 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0033807 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0033874 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033585 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1890467 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034395 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0032914 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033560 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033661 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0033805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034412 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0022939 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032454 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754428
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3284528
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1697428
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1754928
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1778728
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3599828
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 9
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•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1619828
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 10
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 11
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•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 12
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•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 14
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 15
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1720228
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 16
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 17
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Absent
Sex: Pooled
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: false
Specimen Num: 18
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1832128
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 19
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:1205229
Assay Type: RT-PCR
Annotation Date: 1998-06-01
Strength: Present
Sex: Pooled
Emaps: EMAPS:1842628
Stage: TS28
Assay Id: MGI:1205231
Age: postnatal week 6-8
Image: st96_434
Specimen Label: None
Detected: true
Specimen Num: 20
•
•
•
•
•




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