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Search results 1 to 100 out of 511 for Vps54

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0.037s
Type Details Score
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Domain
Type: Family
Description: Vacuolar protein sorting-associated protein 54 (Vps54) is a component of the GARP (Vps52/53/54) complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN) []. Mammalian GARP complex has been shown to play a general role in the delivery of retrograde cargo into the TGN []. In mice, a point mutation (L967Q) in the Vps54 gene causes wobbler mutation, which is characterised by degeneration of upper and lower motor neurons leading to progressive muscle weakness. The wobbler mouse is an animal model for human motor neuron disease, such as amyotrophic lateral sclerosis (ALS) []. Interestingly, the protein mutation (L967Q) does not prevent its integration into the GARP complex but greatly reduces the half-life and levels of the protein in vivo [].
Publication
First Author: PĂ©rez-Victoria FJ
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.
Volume: 107
Issue: 29
Pages: 12860-5
Publication
First Author: Schmitt-John T
Year: 2005
Journal: Nat Genet
Title: Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse.
Volume: 37
Issue: 11
Pages: 1213-5
Protein
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 685  
Fragment?: false
Publication
First Author: Gioria M
Year: 2017
Journal: Cell Tissue Res
Title: Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.
Volume: 369
Issue: 2
Pages: 413-427
Publication
First Author: Karlsson P
Year: 2013
Journal: Int J Mol Sci
Title: Loss of vps54 function leads to vesicle traffic impairment, protein mis-sorting and embryonic lethality.
Volume: 14
Issue: 6
Pages: 10908-25
Publication
First Author: Walter L
Year: 2002
Journal: Gene
Title: Identification, characterization and cytogenetic mapping of a yeast Vps54 homolog in rat and mouse.
Volume: 285
Issue: 1-2
Pages: 213-20
Publication  
First Author: Schmitt-John T
Year: 2015
Journal: Front Neurosci
Title: VPS54 and the wobbler mouse.
Volume: 9
Pages: 381
Publication
First Author: Gonzalez Deniselle MC
Year: 2012
Journal: J Neurochem
Title: Progesterone prevents mitochondrial dysfunction in the spinal cord of wobbler mice.
Volume: 122
Issue: 1
Pages: 185-95
Publication
First Author: Petit CS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of sphingolipid synthesis improves outcomes and survival in GARP mutant wobbler mice, a model of motor neuron degeneration.
Volume: 117
Issue: 19
Pages: 10565-10574
Publication
First Author: Duchen LW
Year: 1968
Journal: J Neurol Neurosurg Psychiatry
Title: An hereditary motor neurone disease with progressive denervation of muscle in the mouse: the mutant 'wobbler'.
Volume: 31
Issue: 6
Pages: 535-42
Publication
First Author: González Deniselle MC
Year: 1999
Journal: Neurochem Res
Title: In vitro differences between astrocytes of control and wobbler mice spinal cord.
Volume: 24
Issue: 12
Pages: 1535-41
Publication
First Author: Staunton L
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Proteomic analysis of muscle affected by motor neuron degeneration: the wobbler mouse model of amyotrophic lateral sclerosis.
Volume: 406
Issue: 4
Pages: 595-600
Publication
First Author: Laage S
Year: 1988
Journal: Dev Neurosci
Title: Astrocyte overgrowth in the brain stem and spinal cord of mice affected by spinal atrophy, wobbler.
Volume: 10
Issue: 3
Pages: 190-8
Publication
First Author: Vergani L
Year: 1997
Journal: Neurosci Lett
Title: Effects of low doses of glycosaminoglycans and insulin-like growth factor-I on motor neuron disease in wobbler mouse.
Volume: 228
Issue: 1
Pages: 41-4
Publication
First Author: Ikeda K
Year: 2000
Journal: Brain Res
Title: T-588, a novel neuroprotective agent, delays progression of neuromuscular dysfunction in wobbler mouse motoneuron disease.
Volume: 858
Issue: 1
Pages: 84-91
Publication
First Author: Junier MP
Year: 1998
Journal: Mol Cell Neurosci
Title: Regulation of growth factor gene expression in degenerating motoneurons of the murine mutant wobbler: a cellular patch-sampling/RT-PCR study.
Volume: 12
Issue: 3
Pages: 168-77
Publication
First Author: Blondet B
Year: 1995
Journal: Neurosci Lett
Title: Astrocytosis in wobbler mouse spinal cord involves a population of astrocytes which is glutamine synthetase-negative.
Volume: 183
Issue: 3
Pages: 179-82
Publication
First Author: Dave KR
Year: 2003
Journal: Exp Neurol
Title: Early mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouse.
Volume: 182
Issue: 2
Pages: 412-20
Publication
First Author: Bose P
Year: 1999
Journal: Neurosci Lett
Title: Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn.
Volume: 260
Issue: 3
Pages: 196-200
Publication
First Author: Diana V
Year: 2010
Journal: Exp Neurol
Title: Neural precursor-derived astrocytes of wobbler mice induce apoptotic death of motor neurons through reduced glutamate uptake.
Volume: 225
Issue: 1
Pages: 163-72
Publication  
First Author: Junghans M
Year: 2022
Journal: Front Cell Neurosci
Title: ROS scavengers decrease ÎłH2ax spots in motor neuronal nuclei of ALS model mice in vitro.
Volume: 16
Pages: 963169
Publication
First Author: Yung KK
Year: 1992
Journal: Brain Res
Title: Decrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease.
Volume: 599
Issue: 1
Pages: 175-80
Publication
First Author: Nieto-Gonzalez JL
Year: 2011
Journal: Cereb Cortex
Title: Reduced GABAergic inhibition explains cortical hyperexcitability in the wobbler mouse model of ALS.
Volume: 21
Issue: 3
Pages: 625-35
Publication
First Author: Andrews JM
Year: 1975
Journal: J Neuropathol Exp Neurol
Title: The fine structure of the cervical spinal cord, ventral root and brachial nerves in the wobbler (wr) mouse.
Volume: 34
Issue: 1
Pages: 12-27
Publication    
First Author: Jockusch H
Year: 1991
Title: Defective Sperm Assembly in a Neurological Mutant of the Mouse, Wobbler
Volume: 75
Pages: 861-864
Publication
First Author: Saberi D
Year: 2016
Journal: J Neuropathol Exp Neurol
Title: The Spatiotemporal Pattern of Degeneration in the Cerebellum of the Wobbler Mouse.
Volume: 75
Issue: 4
Pages: 347-57
Publication
First Author: Blondet B
Year: 2001
Journal: Neurosci Lett
Title: Transient massive DNA fragmentation in nervous system during the early course of a murine neurodegenerative disease.
Volume: 305
Issue: 3
Pages: 202-6
Publication
First Author: Deng YP
Year: 1996
Journal: Brain Res
Title: Changes in receptor levels for thyrotropin releasing hormone, serotonin, and substance P in cervical spinal cord of Wobbler mouse: a quantitative autoradiography study during early and late stages of the motoneuron disease.
Volume: 725
Issue: 1
Pages: 49-60
Publication
First Author: Yung KK
Year: 1994
Journal: Brain Res
Title: Alterations in acetylcholinesterase and choline acetyltransferase activities and neuropeptide levels in the ventral spinal cord of the Wobbler mouse during inherited motoneuron disease.
Volume: 638
Issue: 1-2
Pages: 337-42
Publication  
First Author: Broch-Lips M
Year: 2013
Journal: Exp Neurol
Title: Neuro-muscular function in the wobbler murine model of primary motor neuronopathy.
Volume: 248
Pages: 406-15
Publication
First Author: Mitsumoto H
Year: 1994
Journal: Science
Title: Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF.
Volume: 265
Issue: 5175
Pages: 1107-10
Publication
First Author: González Deniselle MC
Year: 1997
Journal: J Steroid Biochem Mol Biol
Title: Glucocorticoid receptors and actions in the spinal cord of the Wobbler mouse, a model for neurodegenerative diseases.
Volume: 60
Issue: 3-4
Pages: 205-13
Publication
First Author: Mitsumoto H
Year: 1993
Journal: Muscle Nerve
Title: Retardation of fast axonal transport in wobbler mice.
Volume: 16
Issue: 5
Pages: 542-7
Publication
First Author: Ikeda K
Year: 1996
Journal: Muscle Nerve
Title: Basic fibroblast growth factor has neuroprotective effects on axotomy-induced spinal motoneuron death and wobbler mouse motoneuron disease.
Volume: 19
Issue: 6
Pages: 794-5
Publication
First Author: Blondet B
Year: 2002
Journal: Brain Res
Title: Motoneuron morphological alterations before and after the onset of the disease in the wobbler mouse.
Volume: 930
Issue: 1-2
Pages: 53-7
Publication  
First Author: Smith ME
Year: 1994
Journal: J Neurol Sci
Title: POMC neuropeptides and their receptors in the neuromuscular system of wobbler mice.
Volume: 124 Suppl
Pages: 56-8
Publication
First Author: Vacca-Galloway LL
Year: 1986
Journal: J Neurosci Res
Title: Substance P neurons sprout in the cervical spinal cord of the wobbler mouse: a model for motoneuron disease.
Volume: 16
Issue: 4
Pages: 657-70
Publication  
First Author: Meyer M
Year: 2015
Journal: Neuroscience
Title: The progesterone receptor agonist Nestorone holds back proinflammatory mediators and neuropathology in the wobbler mouse model of motoneuron degeneration.
Volume: 308
Pages: 51-63
Publication
First Author: Heimann P
Year: 1991
Journal: Differentiation
Title: Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR).
Volume: 47
Issue: 2
Pages: 77-83
Publication
First Author: Pollin MM
Year: 1990
Journal: J Neurocytol
Title: Loss of motor neurons from the median nerve motor nucleus of the mutant mouse 'wobbler'.
Volume: 19
Issue: 1
Pages: 29-38
Publication
First Author: Ishiyama T
Year: 1997
Journal: Exp Neurol
Title: Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: natural history of the motor neuron disease and response to CNTF and BDNF cotreatment.
Volume: 148
Issue: 1
Pages: 247-55
Publication
First Author: Pioro EP
Year: 1998
Journal: Neuroreport
Title: Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry.
Volume: 9
Issue: 13
Pages: 3041-6
Publication
First Author: Murakami T
Year: 1980
Journal: Exp Neurol
Title: Reduced protein synthesis in spinal anterior horn neurons in wobbler mouse mutant.
Volume: 67
Issue: 2
Pages: 423-32
Publication
First Author: Hantaz-Ambroise D
Year: 1994
Journal: J Neurocytol
Title: Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord.
Volume: 23
Issue: 3
Pages: 179-92
Publication
First Author: Boillée S
Year: 2003
Journal: Mol Neurobiol
Title: The wobbler mouse: a neurodegeneration jigsaw puzzle.
Volume: 28
Issue: 1
Pages: 65-106
Publication
First Author: Bose P
Year: 1999
Journal: Brain Res Bull
Title: Effects of assisted feeding on Wobbler mouse motoneuron disease and on serotonergic and peptidergic sprouting in the cervical spinal ventral horn.
Volume: 48
Issue: 4
Pages: 429-39
Publication
First Author: Blondet B
Year: 1992
Journal: Brain Res
Title: Plasminogen activators in the neuromuscular system of the wobbler mutant mouse.
Volume: 580
Issue: 1-2
Pages: 303-10
Publication
First Author: Tsuzaka K
Year: 2001
Journal: Muscle Nerve
Title: Role of brain-derived neurotrophic factor in wobbler mouse motor neuron disease.
Volume: 24
Issue: 4
Pages: 474-80
Publication
First Author: Mitsumoto H
Year: 1986
Journal: Ann Neurol
Title: Impaired slow axonal transport in wobbler mouse motor neuron disease.
Volume: 19
Issue: 1
Pages: 36-43
Publication
First Author: Ikeda K
Year: 1995
Journal: Neurol Res
Title: Neuroprotective effect of basic fibroblast growth factor on wobbler mouse motor neuron disease.
Volume: 17
Issue: 6
Pages: 445-8
Publication
First Author: Krieger C
Year: 1992
Journal: Can J Neurol Sci
Title: Excitatory amino acid receptor antagonist in murine motoneuron disease (the wobbler mouse).
Volume: 19
Issue: 4
Pages: 462-5
Publication
First Author: Gonzalez Deniselle MC
Year: 2016
Journal: Endocrinology
Title: Steroid Profiling in Male Wobbler Mouse, a Model of Amyotrophic Lateral Sclerosis.
Volume: 157
Issue: 11
Pages: 4446-4460
Publication
First Author: Brooks BR
Year: 1978
Journal: Arch Neurol
Title: Decreased spinal cord cGMP in murine (wobbler) spontaneous lower motor neuron degeneration.
Volume: 35
Issue: 9
Pages: 590-1
Publication
First Author: Yung KK
Year: 1992
Journal: Neuroscience
Title: Alteration in the levels of thyrotropin releasing hormone, substance P and enkephalins in the spinal cord, brainstem, hypothalamus and midbrain of the Wobbler mouse at different stages of the motoneuron disease.
Volume: 50
Issue: 1
Pages: 209-22
Publication
First Author: Tomiyama M
Year: 1994
Journal: Brain Res
Title: Quantitative autoradiographic distribution of glutamate receptors in the cervical segment of the spinal cord of the wobbler mouse.
Volume: 650
Issue: 2
Pages: 353-7
Publication
First Author: Gonzalez Deniselle MC
Year: 2005
Journal: Exp Neurol
Title: Progesterone restores retrograde labeling of cervical motoneurons in Wobbler mouse motoneuron disease.
Volume: 195
Issue: 2
Pages: 518-23
Publication
First Author: Bigini P
Year: 2001
Journal: Neuroreport
Title: Glutamate transporters in the spinal cord of the wobbler mouse.
Volume: 12
Issue: 9
Pages: 1815-20
Publication
First Author: González Deniselle MC
Year: 1999
Journal: Neurochem Res
Title: The 21-aminosteroid U-74389F attenuates hyperexpression of GAP-43 and NADPH-diaphorase in the spinal cord of wobbler mouse, a model for amyotrophic lateral sclerosis.
Volume: 24
Issue: 1
Pages: 1-8
Publication
First Author: Meccariello R
Year: 2002
Journal: Biol Reprod
Title: Mouse sperm cell-specific DnaJ first homologue: an evolutionarily conserved protein for spermiogenesis.
Volume: 66
Issue: 5
Pages: 1328-35
Publication
First Author: Zhang YQ
Year: 1992
Journal: Brain Res
Title: Decreased immunoreactive (IR) calcitonin gene-related peptide correlates with sprouting of IR-peptidergic and serotonergic neuronal processes in spinal cord and brain nuclei from the Wobbler mouse during motoneuron disease.
Volume: 587
Issue: 1
Pages: 169-77
Publication
First Author: Ma W
Year: 1992
Journal: Restor Neurol Neurosci
Title: Spiny interneurons identified in the normal mouse spinal cord show alterations in the Wobbler mouse: a model for inherited motoneuron disease.
Volume: 4
Issue: 6
Pages: 381-92
Publication
First Author: Rathke-Hartlieb S
Year: 1999
Journal: Neuroreport
Title: Spatiotemporal progression of neurodegeneration and glia activation in the wobbler neuropathy of the mouse.
Volume: 10
Issue: 16
Pages: 3411-6
Publication
First Author: Ikeda K
Year: 1993
Journal: Muscle Nerve
Title: In vivo and in vitro muscle tensions in wobbler mouse motor neuron disease.
Volume: 16
Issue: 9
Pages: 979-81
Publication
First Author: Leestma JE
Year: 1980
Journal: Am J Pathol
Title: Animal model of human disease: Werdnig-Hoffmann disease (infantile spinal muscular atrophy).
Volume: 100
Issue: 3
Pages: 821-4
Publication
First Author: Augustin M
Year: 1997
Journal: Dev Dyn
Title: Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function.
Volume: 209
Issue: 3
Pages: 286-95
Publication
First Author: Chelmicka-Schorr E
Year: 1982
Journal: J Neurol Sci
Title: Acid protease activity in spinal cord and muscle in wobbler mouse.
Volume: 56
Issue: 2-3
Pages: 141-5
Publication
First Author: González Deniselle MC
Year: 2004
Journal: Brain Res
Title: Progesterone treatment reduces NADPH-diaphorase/nitric oxide synthase in Wobbler mouse motoneuron disease.
Volume: 1014
Issue: 1-2
Pages: 71-9
Publication
First Author: Ma WY
Year: 1991
Journal: J Comp Neurol
Title: Reduced branching and length of dendrites detected in cervical spinal cord motoneurons of Wobbler mouse, a model for inherited motoneuron disease.
Volume: 311
Issue: 2
Pages: 210-22
Publication
First Author: Hantaz-Ambroise D
Year: 2001
Journal: Differentiation
Title: Specific features of chronic astrocyte gliosis after experimental central nervous system (CNS) xenografting and in Wobbler neurological mutant CNS.
Volume: 69
Issue: 2-3
Pages: 100-7
Publication
First Author: Fumagalli E
Year: 2006
Journal: Exp Neurol
Title: Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease.
Volume: 198
Issue: 1
Pages: 114-28
Publication  
First Author: Dockery P
Year: 1997
Journal: J Anat
Title: Neuron volume in the ventral horn in Wobbler mouse motoneuron disease: a light microscope stereological study.
Volume: 191 ( Pt 1)
Pages: 89-98
Publication
First Author: Shi J
Year: 1993
Journal: Brain Res
Title: Thyrotropin-releasing hormone (TRH) neurons sprout in cervical spinal cord of Wobbler mouse.
Volume: 626
Issue: 1-2
Pages: 83-9
Publication
First Author: Moser JM
Year: 2013
Journal: Mol Genet Genomics
Title: The wobbler mouse, an ALS animal model.
Volume: 288
Issue: 5-6
Pages: 207-29
Publication
First Author: Toursel T
Year: 2000
Journal: Exp Neurol
Title: Alterations in contractile properties and expression of myofibrillar proteins in wobbler mouse muscles.
Volume: 162
Issue: 2
Pages: 311-20
Publication
First Author: Corvino V
Year: 2003
Journal: Neurochem Res
Title: S100B protein and 4-hydroxynonenal in the spinal cord of wobbler mice.
Volume: 28
Issue: 2
Pages: 341-5
Publication
First Author: Bose P
Year: 1998
Journal: Brain Res
Title: A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old.
Volume: 813
Issue: 2
Pages: 334-42
Publication
First Author: Clowry GJ
Year: 2004
Journal: Neuropathol Appl Neurobiol
Title: Brainstem motor nuclei respond differentially to degenerative disease in the mutant mouse wobbler.
Volume: 30
Issue: 2
Pages: 148-60
Publication
First Author: Santoro B
Year: 2004
Journal: Neurobiol Dis
Title: Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease.
Volume: 17
Issue: 2
Pages: 349-57
Publication
First Author: Dennis JS
Year: 2009
Journal: Neuroscience
Title: Wobbler mice modeling motor neuron disease display elevated transactive response DNA binding protein.
Volume: 158
Issue: 2
Pages: 745-50
Publication
First Author: Ikeda K
Year: 1998
Journal: J Neurol Sci
Title: Neuronal nitric oxide synthase inhibitor, 7-nitroindazole, delays motor dysfunction and spinal motoneuron degeneration in the wobbler mouse.
Volume: 160
Issue: 1
Pages: 9-15
Publication
First Author: Thielsen KD
Year: 2013
Journal: PLoS One
Title: The Wobbler mouse model of amyotrophic lateral sclerosis (ALS) displays hippocampal hyperexcitability, and reduced number of interneurons, but no presynaptic vesicle release impairments.
Volume: 8
Issue: 12
Pages: e82767
Publication
First Author: Xu GP
Year: 2001
Journal: Neurosci Lett
Title: Dysfunctional mitochondrial respiration in the wobbler mouse brain.
Volume: 300
Issue: 3
Pages: 141-4
Publication  
First Author: Meyer M
Year: 2020
Journal: Brain Res
Title: Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration.
Volume: 1727
Pages: 146551
Publication  
First Author: Falconer DS
Year: 1956
Journal: Mouse News Lett
Title: Wobbler (wr)
Volume: 15
Pages: 23
Publication
First Author: Mitsumoto H
Year: 1994
Journal: Ann Neurol
Title: The effects of ciliary neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease.
Volume: 36
Issue: 2
Pages: 142-8
Publication
First Author: Ikeda K
Year: 1995
Journal: Ann Neurol
Title: Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease.
Volume: 37
Issue: 1
Pages: 47-54
Publication
First Author: Ikeda K
Year: 1995
Journal: Muscle Nerve
Title: Neuroprotective effect of cholinergic differentiation factor/leukemia inhibitory factor on wobbler murine motor neuron disease.
Volume: 18
Issue: 11
Pages: 1344-7
Publication  
First Author: Peviani M
Year: 2014
Journal: Neurobiol Dis
Title: Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.
Volume: 62
Pages: 218-32