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Search results 1 to 100 out of 104 for Vsig4

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Hits by Strain

Hits by Category

Type Details Score
Gene
11326 | VSIG4
Type: gene
Organism: human
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Gene
614262 | VSIG4
Type: gene
Organism: cattle
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Gene
422170 | VSIG4
Type: gene
Organism: chicken
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Gene
709685 | VSIG4
Type: gene
Organism: macaque, rhesus
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Gene
100485017 | vsig4
Type: gene
Organism: frog, western clawed
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Gene
312102 | Vsig4
Type: gene
Organism: rat
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Gene
491925 | VSIG4
Type: gene
Organism: dog, domestic
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Gene
465677 | VSIG4
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:2679720 | Vsig4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Domain
IPR039939 | VSIG4
Type: Family
Description: V-set and Ig domain-containing 4 (VSIG4) is a strong negative regulator of T cell proliferation and IL-2 production []. It also negatively regulates macrophage activation by activating the PI3K/Akt-STAT3 pathway, leading to pyruvate dehydrogenase kinase-2 (PDK2) upregulation and subsequent phosphorylation of pyruvate dehydrogenase, which results in reduction in pyruvate/acetyl-CoA conversion, reduction in mitochondrialreactive oxygen species secretion, and macrophage inhibition [].
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Publication
29109438 | J:255926
First Author: Li J
Year: 2017
Journal: Nat Commun
Title: VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism.
Volume: 8
Issue: 1
Pages: 1322
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Publication
17016562 | J:114496
First Author: Vogt L
Year: 2006
Journal: J Clin Invest
Title: VSIG4, a B7 family-related protein, is a negative regulator of T cell activation.
Volume: 116
Issue: 10
Pages: 2817-26
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Publication
30662948 | J:281762
First Author: Huang X
Year: 2019
Journal: Sci Adv
Title: VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.
Volume: 5
Issue: 1
Pages: eaau7426
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Publication
24862966 | J:211649
First Author: Liao Y
Year: 2014
Journal: Lab Invest
Title: VSIG4 expression on macrophages facilitates lung cancer development.
Volume: 94
Issue: 7
Pages: 706-15
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Publication
32856419 | J:296940
First Author: Hall BM
Year: 2020
Journal: Aging Cell
Title: Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue.
Volume: 19
Issue: 10
Pages: e13219
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Publication
31266632 | J:291119
First Author: Li Y
Year: 2019
Journal: Biochem Biophys Res Commun
Title: Expression of Vsig4 attenuates macrophage-mediated hepatic inflammation and fibrosis in high fat diet (HFD)-induced mice.
Volume: 516
Issue: 3
Pages: 858-865
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Protein
F6TUL9
Organism: Mus musculus/domesticus
Length: 280  
Fragment?: false
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Publication
36063598 | J:328542
 
First Author: Jung K
Year: 2022
Journal: Biochem Biophys Res Commun
Title: VSIG4-expressing tumor-associated macrophages impair anti-tumor immunity.
Volume: 628
Pages: 18-24
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Publication
29235119 | J:261344
First Author: Shin W
Year: 2018
Journal: Eur J Immunol
Title: V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80+ cells regulate oral antigen-specific responses in mouse.
Volume: 48
Issue: 4
Pages: 632-643
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Publication
36440192 | J:332079
 
First Author: Liu MA
Year: 2022
Journal: Front Endocrinol (Lausanne)
Title: Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes.
Volume: 13
Pages: 1037465
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Protein Coding Gene
MGP_CAROLIEiJ_G0033251 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0035924 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0035910 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0035826 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0035893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0035601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2679720 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0036422 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0034888 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0035577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0035731 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0035669 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0035821 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0035704 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0036449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0034587 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0035027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0031790 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0034416 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17548523 | J:125852
First Author: Katschke KJ Jr
Year: 2007
Journal: J Exp Med
Title: A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis.
Volume: 204
Issue: 6
Pages: 1319-25
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1706828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692793
Age: postnatal adult
Image: JAX_1294325
Specimen Label: JAX_1294325
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1925228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692793
Age: postnatal adult
Image: JAX_1370764
Specimen Label: JAX_1370764
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1898428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692793
Age: postnatal adult
Image: JAX_1294327
Specimen Label: JAX_1294327
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3276028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692793
Age: postnatal adult
Image: JAX_1294323
Specimen Label: JAX_1294323
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692793
Age: postnatal adult
Image: JAX_1370763
Specimen Label: JAX_1370763
Detected: true
Specimen Num: 4
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Publication
23280470 | J:193838
First Author: Kim KH
Year: 2013
Journal: Eur J Immunol
Title: CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner.
Volume: 43
Issue: 3
Pages: 667-78
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Publication
16530040 | J:138691
First Author: Helmy KY
Year: 2006
Journal: Cell
Title: CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens.
Volume: 124
Issue: 5
Pages: 915-27
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Publication
29171836 | J:254997
   
First Author: Yuan X
Year: 2017
Journal: Elife
Title: CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells.
Volume: 6
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Publication
29268030 | J:275635
First Author: Nagre N
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung.
Volume: 58
Issue: 6
Pages: 756-766
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Publication
34887405 | J:335788
First Author: Duan Y
Year: 2021
Journal: Nat Commun
Title: CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease.
Volume: 12
Issue: 1
Pages: 7172
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Publication
19017980 | J:142380
First Author: Gorgani NN
Year: 2008
Journal: J Immunol
Title: Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages.
Volume: 181
Issue: 11
Pages: 7902-8
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Publication
35258552 | J:344863
 
First Author: An H
Year: 2022
Journal: J Exp Med
Title: Functional vulnerability of liver macrophages to capsules defines virulence of blood-borne bacteria.
Volume: 219
Issue: 4
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Publication
31723045 | J:290773
First Author: Liu G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement.
Volume: 116
Issue: 48
Pages: 24214-24220
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Publication
23225913 | J:193858
First Author: He JQ
Year: 2013
Journal: J Leukoc Biol
Title: CRIg mediates early Kupffer cell responses to adenovirus.
Volume: 93
Issue: 2
Pages: 301-6
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Publication
36821387 | J:335481
 
First Author: Liu W
Year: 2023
Journal: J Clin Invest
Title: In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis.
Volume: 133
Issue: 8
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Publication
19136662 | J:146538
First Author: Miwa T
Year: 2009
Journal: Blood
Title: Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry.
Volume: 113
Issue: 12
Pages: 2684-94
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Publication
31594939 | J:281372
First Author: Sun D
Year: 2019
Journal: Nat Commun
Title: Fungal dissemination is limited by liver macrophage filtration of the blood.
Volume: 10
Issue: 1
Pages: 4566
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Publication
18524992 | J:138410
First Author: Kim DD
Year: 2008
Journal: Blood
Title: Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg.
Volume: 112
Issue: 4
Pages: 1109-19
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Publication
36103821 | J:329456
First Author: Spring J
Year: 2022
Journal: Cell Rep
Title: Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus.
Volume: 40
Issue: 11
Pages: 111341
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12477932 | J:82808
First Author: Strausberg RL
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Volume: 99
Issue: 26
Pages: 16899-903
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Allele
Vsig4<em2Smoc> | MGI:7293143
Name: V-set and immunoglobulin domain containing 4; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Vsig4<em1(VSIG4)Smoc> | MGI:7293142
Name: V-set and immunoglobulin domain containing 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:6771263 | C57BL/6J-Vsig4<em1(VSIG4)Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
27889311 | -
First Author: Wen Y
Year: 2017
Journal: Immunobiology
Title: Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity.
Volume: 222
Issue: 6
Pages: 807-813
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Publication
21460840 | -
First Author: Hollingworth P
Year: 2011
Journal: Nat Genet
Title: Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
Volume: 43
Issue: 5
Pages: 429-35
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Publication
23226438 | -
First Author: Karch CM
Year: 2012
Journal: PLoS One
Title: Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains.
Volume: 7
Issue: 11
Pages: e50976
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Publication
23360175 | -
First Author: Holton P
Year: 2013
Journal: Ann Hum Genet
Title: Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci.
Volume: 77
Issue: 2
Pages: 85-105
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Protein Domain
IPR030427 | MS4A6A-E
Type: Family
Description: MS4A6A/B/C/D/E are members of the membrane-spanning 4-domains family A (MS4A), which contains at least 16 members in human. MS4A6D has been shown to interact with VSIG4 to form a surface signaling complex, which activates JAK2-STAT3-A20 cascades to inhibit NF-kB activation []. MS4A6A and MS4A6E variants have been associated with Alzheimer's disease [, , ].
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HT Experiment
GSE217145 | Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
37429063 | J:342776
 
First Author: Chen Y
Year: 2023
Journal: Mol Immunol
Title: Tetraspan MS4A6D is a coreceptor of MHC class II antigen (MHC-II) that promotes macrophages-derived inflammation.
Volume: 160
Pages: 121-132
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Publication
34874921 | J:322626
 
First Author: Zhao D
Year: 2022
Journal: J Clin Invest
Title: ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection.
Volume: 132
Issue: 3
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Protein
Q99N07
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: false
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Protein
Q99N09
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
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Protein
Q99N08
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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