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Search results 1 to 100 out of 192 for Wasl

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0.038s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Actin nucleation-promoting factor WASL belongs to the WASP family, whose members signal to the cytoskeleton through the Arp2/3 complex, an actin-nucleating assembly that regulates the structure and dynamics of actin filament networks at the leading edge of the cell []. WASP family members have unique N-terminal regions, followed by a central segment rich in proline, and a common C-terminal region. Their conserved C-terminal VCA domain consists of two WH2 (WASP homology 2) domains ("V"referring to either a single or multiple WH2 domains), followed by a connector domain ("C") and an acidic short extension ("A"). In the VCA region, the WH2 domain(s) bind G-actin, whereas the CA domain binds Arp2/3 complex []. Their distinct N-terminal region enables family members to activate Arp2/3 in response to different upstream signals.Interestingly, pathogen such as enteropathogenic Escherichia coli can affect host cell Arp2/3-dependent actin assembly through injecting a bacterial protein, translocated intimin receptor (Tir), into the host cell [, ]. Tir binds to the host-cell adaptor protein Nck. Nck interacts with a complex of WIP and N-WASP, resulting in the activation of the Arp2/3 complex and actin polymerisation []. Vaccinia virus can also affect actin assembly in the host cells through the interaction between its transmembrane protein A36 and host proteins, such as Grb2, Nck, WIP and N-WASP. Arp2/3-induced actin polymerisation propels the virus away from the cell surface towards neighbouring cells, enhancing the spread of infection [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Donnelly SK
Year: 2013
Journal: Curr Biol
Title: WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.
Volume: 23
Issue: 11
Pages: 999-1006
Publication
First Author: Garber JJ
Year: 2012
Journal: Infect Immun
Title: Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.
Volume: 80
Issue: 12
Pages: 4071-7
Protein
Organism: Mus musculus/domesticus
Length: 189  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
Gene
Type: gene
Organism: human
Publication  
First Author: Hidalgo-Sastre A
Year: 2020
Journal: JCI Insight
Title: Loss of Wasl improves pancreatic cancer outcome.
Volume: 5
Issue: 10
Publication
First Author: Humphries AC
Year: 2014
Journal: J Cell Sci
Title: Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
Volume: 127
Issue: Pt 3
Pages: 673-85
Publication
First Author: Cheng HC
Year: 2008
Journal: Nature
Title: Structural mechanism of WASP activation by the enterohaemorrhagic E. coli effector EspF(U).
Volume: 454
Issue: 7207
Pages: 1009-13
Publication
First Author: Gaucher JF
Year: 2012
Journal: J Biol Chem
Title: Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex.
Volume: 287
Issue: 41
Pages: 34646-59
Protein
Organism: Mus musculus/domesticus
Length: 182  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 443  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
Publication
First Author: Hawkins MB
Year: 2021
Journal: Cell
Title: Latent developmental potential to form limb-like skeletal structures in zebrafish.
Volume: 184
Issue: 4
Pages: 899-911.e13
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Almeida-Souza L
Year: 2018
Journal: Cell
Title: A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.
Volume: 174
Issue: 2
Pages: 325-337.e14
Publication
First Author: Lommel S
Year: 2001
Journal: EMBO Rep
Title: Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP-defective cells.
Volume: 2
Issue: 9
Pages: 850-7
Publication  
First Author: Jain N
Year: 2014
Journal: Exp Neurol
Title: Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology.
Volume: 254
Pages: 29-40
Publication
First Author: Xiao X
Year: 2014
Journal: PLoS Genet
Title: N-wasp is required for structural integrity of the blood-testis barrier.
Volume: 10
Issue: 6
Pages: e1004447
Publication
First Author: Rotkopf S
Year: 2011
Journal: Development
Title: The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release.
Volume: 138
Issue: 13
Pages: 2729-39
Publication
First Author: Novak N
Year: 2011
Journal: J Cell Biol
Title: N-WASP is required for membrane wrapping and myelination by Schwann cells.
Volume: 192
Issue: 2
Pages: 243-50
Publication
First Author: Schell C
Year: 2013
Journal: J Am Soc Nephrol
Title: N-wasp is required for stabilization of podocyte foot processes.
Volume: 24
Issue: 5
Pages: 713-21
Publication
First Author: Jin F
Year: 2011
Journal: Development
Title: N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination.
Volume: 138
Issue: 7
Pages: 1329-37
Publication  
First Author: Jain N
Year: 2016
Journal: Sci Rep
Title: Conditional knockout of N-WASP in mouse fibroblast caused keratinocyte hyper proliferation and enhanced wound closure.
Volume: 6
Pages: 38109
Publication
First Author: Kalailingam P
Year: 2017
Journal: Sci Rep
Title: Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation.
Volume: 7
Issue: 1
Pages: 7311
Publication
First Author: Wagener BM
Year: 2016
Journal: FASEB J
Title: Neuronal Wiskott-Aldrich syndrome protein regulates TGF-β1-mediated lung vascular permeability.
Volume: 30
Issue: 7
Pages: 2557-69
Publication
First Author: Misra A
Year: 2010
Journal: Exp Cell Res
Title: The mammalian verprolin, WIRE induces filopodia independent of N-WASP through IRSp53.
Volume: 316
Issue: 17
Pages: 2810-24
Publication
First Author: Li H
Year: 2019
Journal: Cancer Res
Title: Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation.
Volume: 79
Issue: 9
Pages: 2167-2181
Publication
First Author: Lefever T
Year: 2010
Journal: J Cell Sci
Title: N-WASP is a novel regulator of hair-follicle cycling that controls antiproliferative TGF{beta} pathways.
Volume: 123
Issue: Pt 1
Pages: 128-40
Publication
First Author: Misra A
Year: 2007
Journal: Biochem Biophys Res Commun
Title: N-WASP plays a critical role in fibroblast adhesion and spreading.
Volume: 364
Issue: 4
Pages: 908-12
Publication
First Author: Guenin-Macé L
Year: 2013
Journal: J Clin Invest
Title: Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.
Volume: 123
Issue: 4
Pages: 1501-12
GXD Expression    
Probe: MGI:5661224
Assay Type: RT-PCR
Annotation Date: 2015-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5661307
Age: postnatal adult
Image: 1
Specimen Label: Brain
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5661224
Assay Type: RT-PCR
Annotation Date: 2015-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5661307
Age: postnatal adult
Image: 1
Specimen Label: Liver
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:5661224
Assay Type: RT-PCR
Annotation Date: 2015-09-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5661307
Age: postnatal adult
Image: 1
Specimen Label: Spleen
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5699302
Assay Type: Western blot
Annotation Date: 2015-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684624
Stage: TS24
Assay Id: MGI:5699324
Age: embryonic day 16.5
Specimen Label: Liver
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5699302
Assay Type: Western blot
Annotation Date: 2015-12-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689424
Stage: TS24
Assay Id: MGI:5699324
Age: embryonic day 16.5
Specimen Label: Brain
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2769723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2853323
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2845723
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1795023
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1869223
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2854023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2762123
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:1832123
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2851823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2760523
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2852723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2874723
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11106
Specimen Label: GUDMAP:11106
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:2850023
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: false
Specimen Num: 2
GXD Expression  
Probe: MGI:5002222
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:1796223
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5542776
Age: embryonic day 15.5
Image: GUDMAP:11135
Specimen Label: GUDMAP:11135
Detected: true
Specimen Num: 2
Publication
First Author: Suetsugu S
Year: 2007
Journal: Genes Cells
Title: Male-specific sterility caused by the loss of CR16.
Volume: 12
Issue: 6
Pages: 721-33
Publication
First Author: Lyubimova A
Year: 2010
Journal: J Clin Invest
Title: Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice.
Volume: 120
Issue: 2
Pages: 446-56
Publication
First Author: Cotta-de-Almeida V
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development.
Volume: 104
Issue: 39
Pages: 15424-9
Publication
First Author: Isaac BM
Year: 2010
Journal: Exp Cell Res
Title: N-WASP has the ability to compensate for the loss of WASP in macrophage podosome formation and chemotaxis.
Volume: 316
Issue: 20
Pages: 3406-16
Publication
First Author: Katanov C
Year: 2020
Journal: J Neurosci
Title: N-Wasp Regulates Oligodendrocyte Myelination.
Volume: 40
Issue: 32
Pages: 6103-6111
Publication
First Author: Rey-Suarez I
Year: 2020
Journal: Nat Commun
Title: WASP family proteins regulate the mobility of the B cell receptor during signaling activation.
Volume: 11
Issue: 1
Pages: 439
Publication
First Author: Che P
Year: 2020
Journal: FASEB J
Title: Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics.
Volume: 34
Issue: 2
Pages: 3305-3317