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Search results 1 to 100 out of 102 for Wdr81

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Type Details Score
Gene
124997 | WDR81
Type: gene
Organism: human
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Gene
100485582 | wdr81
Type: gene
Organism: frog, western clawed
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Gene
303312 | Wdr81
Type: gene
Organism: rat
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Gene
468136 | WDR81
Type: gene
Organism: chimpanzee
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Gene
611263 | WDR81
Type: gene
Organism: dog, domestic
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Gene
514104 | WDR81
Type: gene
Organism: cattle
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Gene
417560 | WDR81
Type: gene
Organism: chicken
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Gene
100333062 | wdr81
Type: gene
Organism: zebrafish
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Gene
721254 | WDR81
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR052651 | WDR81
Type: Family
Description: WD repeat-containing protein 81 (WDR81) functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate content of endosomal membranes, it regulates endosome fusion, recycling, sorting, and early to late endosome transport []. It is required for the delivery of cargos like BST2/tetherin from the early to late endosome, thereby participating indirectly in their degradation by the lysosome []. WDR81 also plays a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates, by regulating the interaction of SQSTM1 with ubiquitinated proteins and recruiting MAP1LC3C []. Furthermore, it is involved in the maintenance of normal mitochondrial structure and organisation []. The protein typically contains a BEACH domain and multiple WD40 repeats. In humans, mutations in the WDR81 gene are associated with cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2 (CAMRQ2) [, ], as well as congenital hydrocephalus [].
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Protein Coding Gene
MGI:2681828 | Wdr81
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23595742 | J:196651
First Author: Traka M
Year: 2013
Journal: J Neurosci
Title: WDR81 is necessary for purkinje and photoreceptor cell survival.
Volume: 33
Issue: 16
Pages: 6834-44
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Publication
28404643 | J:249660
First Author: Liu X
Year: 2017
Journal: J Cell Biol
Title: The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy.
Volume: 216
Issue: 5
Pages: 1301-1320
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Gene
138842264 | WDR81-AS1
Type: gene
Organism: human
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Publication
30531936 | J:288401
First Author: Wang M
Year: 2021
Journal: Mol Psychiatry
Title: WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGF? signaling.
Volume: 26
Issue: 2
Pages: 694-709
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GXD Expression
GXD Expression
   
Probe: MGI:7264452
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7264455
Age: embryonic day 14.5
Image: 1
Specimen Label: WDR81 KO1 ISO1
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:7264453
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7264456
Age: embryonic day 14.5
Image: 1
Specimen Label: WDR81 KO1 ISO2
Detected: true
Specimen Num: 4
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Publication
21885617 | J:183568
First Author: Gulsuner S
Year: 2011
Journal: Genome Res
Title: Homozygosity mapping and targeted genomic sequencing reveal the gene responsible for cerebellar hypoplasia and quadrupedal locomotion in a consanguineous kindred.
Volume: 21
Issue: 12
Pages: 1995-2003
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Publication
26437881 | -
First Author: Komara M
Year: 2016
Journal: Am J Med Genet A
Title: Clinical and molecular delineation of dysequilibrium syndrome type 2 and profound sensorineural hearing loss in an inbred Arab family.
Volume: 170A
Issue: 2
Pages: 540-543
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Publication
27126989 | -
First Author: Rapiteanu R
Year: 2016
Journal: Traffic
Title: A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin.
Volume: 17
Issue: 8
Pages: 940-58
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Publication
28556411 | -
First Author: Shaheen R
Year: 2017
Journal: Ann Neurol
Title: The genetic landscape of familial congenital hydrocephalus.
Volume: 81
Issue: 6
Pages: 890-897
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Protein
F6XD87
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: true
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Protein
Q3UU62
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: true
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Protein
Q68EM0
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: true
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Protein
Q6P8W0
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: true
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Protein
Q8R159
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: true
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Publication
26783301 | -
First Author: Liu K
Year: 2016
Journal: J Cell Biol
Title: Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion.
Volume: 212
Issue: 2
Pages: 181-98
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Protein
Q5ND34
Organism: Mus musculus/domesticus
Length: 1934  
Fragment?: false
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Protein
K4DI77
Organism: Mus musculus/domesticus
Length: 1934  
Fragment?: true
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Publication
- | J:267697
     
First Author: Ludwig S
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for jello.
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Publication
35013230 | J:318768
First Author: Carpentieri JA
Year: 2022
Journal: Nat Commun
Title: Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly.
Volume: 13
Issue: 1
Pages: 16
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Protein Coding Gene
MGP_CAROLIEiJ_G0016738 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
ENSMUSG00200051182 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00195036970 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00220046672 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00180033419 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00175036798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2681828 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00215031310 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSTCUG00005053601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00210046200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00185039503 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00205028109 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00230041489 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSUMUG00000041470 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00190044803 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSMUSG00225037630 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSLUMG00010020339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
ENSIUOG00005034417 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017875 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
ENSMSPG00010041606 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7264452
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7264455
Age: embryonic day 14.5
Image: 1
Specimen Label: WT ISO1
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7264453
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7264456
Age: embryonic day 14.5
Image: 1
Specimen Label: WT ISO2
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7264452
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754420
Stage: TS20
Assay Id: MGI:7264457
Age: embryonic day 12.5
Image: S1
Specimen Label: E12.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7264452
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754422
Stage: TS22
Assay Id: MGI:7264457
Age: embryonic day 14.5
Image: S1
Specimen Label: E14.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7264452
Assay Type: RT-PCR
Annotation Date: 2022-04-26
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Stage: TS24
Assay Id: MGI:7264457
Age: embryonic day 16.5
Image: S1
Specimen Label: E16.5
Detected: true
Specimen Num: 3
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Publication
12955145 | J:85113
First Author: Kile BT
Year: 2003
Journal: Nature
Title: Functional genetic analysis of mouse chromosome 11.
Volume: 425
Issue: 6953
Pages: 81-6
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
15449545 | J:92574
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 2
Pages: 127-35
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Publication
34161765 | J:306626
First Author: Wang X
Year: 2021
Journal: Cell Rep
Title: DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.
Volume: 35
Issue: 12
Pages: 109281
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
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Publication
- | J:384794
     
First Author: MGI and IMPC
Year: 2026
Journal: Database Release
Title: MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:389486
     
First Author: Mouse Genome Informatics and Ensembl Genome Database Project
Year: 2026
Journal: Database Release
Title: MGI Strain Genome Feature and Gene Model Load from Ensembl.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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DO Term
DOID:0070684 | congenital hydrocephalus 3
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DO Term
DOID:0070557 | cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2
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Allele
Wdr81<nur5> | MGI:2671731
 
Name: WD repeat domain 81; neurological 5
Allele Type: Chemically induced (ENU)
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Strain
MGI:5771533 | B6J(129S7)-Wrd81<nur5>/PopJ
Attribute String: coisogenic, mutant strain, chemically induced mutation
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Allele
Wdr81<m1Btlr> | MGI:6269421
Name: WD repeat domain 81; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6269422 | C57BL/6J-Wdr81<m1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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