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Search results 1 to 100 out of 600 for Wnk1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Shekarabi M
Year: 2008
Journal: J Clin Invest
Title: Mutations in the nervous system--specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II.
Volume: 118
Issue: 7
Pages: 2496-505
Publication
First Author: Susa K
Year: 2014
Journal: Hum Mol Genet
Title: Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.
Volume: 23
Issue: 19
Pages: 5052-60
Publication
First Author: Chi RA
Year: 2023
Journal: iScience
Title: WNK1 is required during male pachynema to sustain fertility.
Volume: 26
Issue: 9
Pages: 107616
Publication
First Author: Boyd-Shiwarski CR
Year: 2018
Journal: Mol Biol Cell
Title: Potassium-regulated distal tubule WNK bodies are kidney-specific WNK1 dependent.
Volume: 29
Issue: 4
Pages: 499-509
Publication
First Author: Köchl R
Year: 2016
Journal: Nat Immunol
Title: WNK1 kinase balances T cell adhesion versus migration in vivo.
Volume: 17
Issue: 9
Pages: 1075-83
Publication
First Author: Mayes-Hopfinger L
Year: 2021
Journal: Nat Commun
Title: Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis.
Volume: 12
Issue: 1
Pages: 4546
Publication    
First Author: Köchl R
Year: 2020
Journal: Elife
Title: Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
Volume: 9
Publication
First Author: Lee BH
Year: 2004
Journal: Mol Cell
Title: WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding.
Volume: 15
Issue: 5
Pages: 741-51
Publication
First Author: Roy A
Year: 2015
Journal: J Clin Invest
Title: Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
Volume: 125
Issue: 9
Pages: 3433-48
Publication  
First Author: Chi RA
Year: 2020
Journal: JCI Insight
Title: WNK1 regulates uterine homeostasis and its ability to support pregnancy.
Volume: 5
Issue: 22
Publication
First Author: Xie J
Year: 2013
Journal: J Biol Chem
Title: WNK1 protein kinase regulates embryonic cardiovascular development through the OSR1 signaling cascade.
Volume: 288
Issue: 12
Pages: 8566-74
Publication
First Author: Rafael C
Year: 2018
Journal: Sci Rep
Title: Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4.
Volume: 8
Issue: 1
Pages: 3249
Publication
First Author: Xie J
Year: 2009
Journal: Am J Pathol
Title: Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice.
Volume: 175
Issue: 3
Pages: 1315-27
Publication  
First Author: Hayward DA
Year: 2023
Journal: J Exp Med
Title: B cell-intrinsic requirement for WNK1 kinase in antibody responses in mice.
Volume: 220
Issue: 3
Publication
First Author: Liu Z
Year: 2009
Journal: J Biol Chem
Title: Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.
Volume: 284
Issue: 18
Pages: 12198-206
Publication
First Author: Bergaya S
Year: 2011
Journal: Hypertension
Title: WNK1 regulates vasoconstriction and blood pressure response to α 1-adrenergic stimulation in mice.
Volume: 58
Issue: 3
Pages: 439-45
Publication
First Author: Cheng CJ
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb.
Volume: 303
Issue: 5
Pages: F667-73
Publication
First Author: Louis-Dit-Picard H
Year: 2020
Journal: J Clin Invest
Title: Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis.
Volume: 130
Issue: 12
Pages: 6379-6394
Publication
First Author: Cheng CJ
Year: 2013
Journal: Am J Physiol Renal Physiol
Title: Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.
Volume: 304
Issue: 4
Pages: F397-402
Publication
First Author: Lee BH
Year: 2007
Journal: J Biol Chem
Title: Biological cross-talk between WNK1 and the transforming growth factor beta-Smad signaling pathway.
Volume: 282
Issue: 25
Pages: 17985-96
Publication
First Author: Mandai S
Year: 2018
Journal: Sci Rep
Title: WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4.
Volume: 8
Issue: 1
Pages: 9101
Publication
First Author: Chung WY
Year: 2018
Journal: Mol Cell Biochem
Title: Overexpression of WNK1 in POMC-expressing neurons reduces weigh gain via WNK4-mediated degradation of Kir6.2.
Volume: 447
Issue: 1-2
Pages: 165-174
Publication
First Author: Chávez-Canales M
Year: 2014
Journal: Hypertension
Title: WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.
Volume: 64
Issue: 5
Pages: 1047-53
Publication
First Author: Susa K
Year: 2012
Journal: Clin Exp Nephrol
Title: Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.
Volume: 16
Issue: 4
Pages: 530-8
Publication
First Author: Delaloy C
Year: 2006
Journal: Am J Pathol
Title: Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.
Volume: 169
Issue: 1
Pages: 105-18
Publication
First Author: Liu Z
Year: 2011
Journal: Hum Mol Genet
Title: Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.
Volume: 20
Issue: 5
Pages: 855-66
Publication
First Author: Shekarabi M
Year: 2013
Journal: PLoS One
Title: Comparative analysis of the expression profile of Wnk1 and Wnk1/Hsn2 splice variants in developing and adult mouse tissues.
Volume: 8
Issue: 2
Pages: e57807
Publication
First Author: Hadchouel J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.
Volume: 107
Issue: 42
Pages: 18109-14
Publication
First Author: Jiang ZY
Year: 2005
Journal: J Biol Chem
Title: Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.
Volume: 280
Issue: 22
Pages: 21622-8
Publication
First Author: Dbouk HA
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.
Volume: 111
Issue: 45
Pages: 15999-6004
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Wu P
Year: 2018
Journal: Am J Physiol Renal Physiol
Title: Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.
Volume: 315
Issue: 2
Pages: F223-F230
Publication
First Author: O'Reilly M
Year: 2003
Journal: J Am Soc Nephrol
Title: WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
Volume: 14
Issue: 10
Pages: 2447-56
Publication
First Author: Wilson FH
Year: 2001
Journal: Science
Title: Human hypertension caused by mutations in WNK kinases.
Volume: 293
Issue: 5532
Pages: 1107-12
Publication
First Author: Yang CL
Year: 2003
Journal: J Clin Invest
Title: WNK kinases regulate thiazide-sensitive Na-Cl cotransport.
Volume: 111
Issue: 7
Pages: 1039-45
Publication
First Author: Yang D
Year: 2011
Journal: J Clin Invest
Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.
Volume: 121
Issue: 3
Pages: 956-65
Publication
First Author: Vidal-Petiot E
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.
Volume: 110
Issue: 35
Pages: 14366-71
Publication
First Author: Choate KA
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
Volume: 100
Issue: 2
Pages: 663-8
Publication
First Author: Kahle KT
Year: 2016
Journal: Sci Signal
Title: Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition.
Volume: 9
Issue: 421
Pages: ra32
Publication
First Author: Friedel P
Year: 2015
Journal: Sci Signal
Title: WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons.
Volume: 8
Issue: 383
Pages: ra65
Publication
First Author: Sato A
Year: 2013
Journal: PLoS One
Title: WNK signaling is involved in neural development via Lhx8/Awh expression.
Volume: 8
Issue: 1
Pages: e55301
Publication
First Author: Izadifar A
Year: 2021
Journal: Neuron
Title: Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.
Volume: 109
Issue: 18
Pages: 2864-2883.e8
Publication
First Author: Shibata S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Volume: 110
Issue: 19
Pages: 7838-43
Publication
First Author: Ostrosky-Frid M
Year: 2021
Journal: Am J Physiol Renal Physiol
Title: Role of KLHL3 and dietary K+ in regulating KS-WNK1 expression.
Volume: 320
Issue: 5
Pages: F734-F747
Publication
First Author: Rinehart J
Year: 2011
Journal: J Biol Chem
Title: WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.
Volume: 286
Issue: 34
Pages: 30171-80
UniProt Feature
Begin: 1
Description: Serine/threonine-protein kinase WNK1
Type: chain
End: 2377
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: brain
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1666828
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: DRG
Detected: false
Specimen Num: 3
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: heart
Detected: false
Specimen Num: 4
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: kidney
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: lung
Detected: false
Specimen Num: 6
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: spleen
Detected: false
Specimen Num: 7
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: testis
Detected: false
Specimen Num: 8
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: thymus
Detected: false
Specimen Num: 9
GXD Expression    
Probe: MGI:5810723
Assay Type: RT-PCR
Annotation Date: 2016-12-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5811233
Age: postnatal adult
Image: S3
Specimen Label: liver
Detected: false
Specimen Num: 10
GXD Expression      
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Specimen Label: MH1821; Specimen C1791
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1716122
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Image: MH1821; Specimen C1791
Specimen Label: MH1821; Specimen C1791
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884039
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Regionally restricted
Stage: TS19
Assay Id: MGI:4944602
Age: embryonic day 11.5
Note: Expression was region specific and scattered.
Specimen Label: g00011 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884039
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4944602
Age: embryonic day 15.5
Note: Expression was region specific and scattered.
Specimen Label: g00011 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4884121
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691619
Pattern: Widespread
Stage: TS19
Assay Id: MGI:4945722
Age: embryonic day 11.5
Image: g01327 E11.5
Specimen Label: g01327 E11.5
Detected: true
Specimen Num: 1
GXD Expression  
Probe: MGI:4884121
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1691623
Pattern: Widespread
Stage: TS23
Assay Id: MGI:4945722
Age: embryonic day 15.5
Image: g01327 E15.5
Specimen Label: g01327 E15.5
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Image: MH1821; Specimen C1791
Specimen Label: MH1821; Specimen C1791
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5810724
Assay Type: RNA in situ
Annotation Date: 2016-12-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3538628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5810731
Age: postnatal adult
Image: 5D
Note: Stronger expression than Wnk1/Hsn2.
Specimen Label: 5D
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:5810725
Assay Type: RNA in situ
Annotation Date: 2016-12-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3538628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5811086
Age: postnatal adult
Image: 5E
Specimen Label: 5E
Detected: true
Specimen Num: 9
GXD Expression  
Probe: MGI:5810724
Assay Type: RNA in situ
Annotation Date: 2016-12-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5810731
Age: postnatal adult
Image: 11A
Specimen Label: 11A
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5810725
Assay Type: RNA in situ
Annotation Date: 2016-12-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5811086
Age: postnatal adult
Image: 11B
Specimen Label: 11B
Detected: true
Specimen Num: 17
GXD Expression  
Probe: MGI:5810724
Assay Type: RNA in situ
Annotation Date: 2016-12-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5810731
Age: postnatal adult
Image: 11D
Specimen Label: 11D
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:5810725
Assay Type: RNA in situ
Annotation Date: 2016-12-06
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5811086
Age: postnatal adult
Image: 11E
Specimen Label: 11E
Detected: true
Specimen Num: 18
GXD Expression  
Probe: MGI:5810730
Assay Type: Immunohistochemistry
Annotation Date: 2016-12-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5811154
Age: postnatal adult
Image: 11H/I
Specimen Label: 11H/I
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2839328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5540652
Age: postnatal day 84
Image: GUDMAP:14686
Specimen Label: GUDMAP:14686
Detected: true
Specimen Num: 2
GXD Expression  
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1760622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Image: MH1821; Specimen C1791
Specimen Label: MH1821; Specimen C1791
Detected: true
Specimen Num: 1
GXD Expression
Probe: MGI:5810724
Assay Type: RNA in situ
Annotation Date: 2016-12-02
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1760627
Pattern: Non-Uniform
Stage: TS27
Assay Id: MGI:5810731
Age: postnatal day 1
Image: 2F
Note: Heterogeneousm distribution.
Specimen Label: 2F
Detected: true
Specimen Num: 4