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Search results 1 to 100 out of 1934 for Wnt4

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Type Details Score
Gene
54361 | WNT4
Type: gene
Organism: human
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Gene
789600 | WNT4
Type: gene
Organism: cattle
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Gene
395561 | WNT4
Type: gene
Organism: chicken
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Gene
30123 | wnt4
Type: gene
Organism: zebrafish
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Gene
707864 | WNT4
Type: gene
Organism: macaque, rhesus
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Gene
100491282 | wnt4
Type: gene
Organism: frog, western clawed
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Gene
84426 | Wnt4
Type: gene
Organism: rat
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Gene
612367 | WNT4
Type: gene
Organism: dog, domestic
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Gene
469212 | WNT4
Type: gene
Organism: chimpanzee
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Protein Domain
IPR009142 | Wnt4
Type: Family
Description: Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) []. It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals []. Wnt signalling has been implicated in tumourigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease [, ].Wnt-mediated signalling is believed to proceed initially through binding to cell surface receptors of the frizzled family; the signal is subsequently transduced through several cytoplasmic components to B-catenin, which enters the nucleus and activates the transcription of several genes important indevelopment []. Several non-canonical Wnt signalling pathways have also been elucidated that act independently of B-catenin. Canonical and noncanonical Wnt signaling branches are highly interconnected, and cross-regulate each other [].Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteins of ~350-400 residues in length, with orthologues identified in several, mostly vertebrate, species. Very little is known about the structure of Wnts as they are notoriously insoluble, but they share the following features characteristics of secretory proteins: a signal peptide, several potential N-glycosylation sites and 22 conserved cysteines []that are probably involved in disulphide bonds. The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few cell diameters. Fifteen major Wnt gene families have been identified in vertebrates, with multiple subtypes within some classes.Wnt-4 cDNA was isolated from mouse using a PCR-based strategy, where it wasfound to be expressed in adult tissues, particularly in brain and lung [].Wnt-4 is believed to act downstream of progesterone signalling to playan important role in mammary gland development. Furthermore, mutationsin the Wnt-4 gene have been linked to kidney defects [].
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Protein Coding Gene
MGI:98957 | Wnt4
Type: protein_coding_gene
Organism: mouse, laboratory
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GXD Expression
GXD Expression
 
Probe: MGI:5447684
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2775623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5448142
Age: embryonic day 15.5
Image: 3A Wnt4
Specimen Label: 3A Wnt4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:5447684
Assay Type: RNA in situ
Annotation Date: 2013-01-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2767823
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5448142
Age: embryonic day 15.5
Image: 3A Wnt4
Specimen Label: 3A Wnt4
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7466953
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Absent
Sex: Female
Emaps: EMAPS:1796320
Stage: TS20
Assay Id: MGI:7467152
Age: embryonic day 12.5
Image: 8B Wnt4
Specimen Label: 8B Wnt4
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7466953
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:7467152
Age: embryonic day 12.5
Image: 8B Wnt4
Note: Expression is not detected 1-2 cell layers below the epithelium.
Specimen Label: 8B Wnt4
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7466953
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467152
Age: embryonic day 13.5
Image: 8C Wnt4
Note: Expression is seen in somatic cells.
Specimen Label: 8C Wnt4
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:7466953
Assay Type: RNA in situ
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467152
Age: embryonic day 13.5
Image: 8A Wnt4
Note: In somatic cells high expression levels are seen from the mesonephros (future ovarian medulla) up to a few cell layers from the coelomic epithelium (future ovarian cortex).
Specimen Label: 8A Wnt4
Detected: true
Specimen Num: 1
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Publication
7990960 | J:21884
First Author: Stark K
Year: 1994
Journal: Nature
Title: Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4.
Volume: 372
Issue: 6507
Pages: 679-83
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Publication
2279700 | J:10971
First Author: Gavin BJ
Year: 1990
Journal: Genes Dev
Title: Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.
Volume: 4
Issue: 12B
Pages: 2319-32
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Publication
9891778 | J:52724
 
First Author: Wodarz A
Year: 1998
Journal: Annu Rev Cell Dev Biol
Title: Mechanisms of Wnt signaling in development.
Volume: 14
Pages: 59-88
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GXD Expression
GXD Expression
     
Probe: MGI:3513366
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:3513384
Age: embryonic day 3.0
Specimen Label: Wnt4
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
     
Probe: MGI:3513366
Assay Type: RT-PCR
Annotation Date: 2005-01-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360465
Stage: TS05
Assay Id: MGI:3513402
Age: embryonic day 4.0
Specimen Label: Wnt4
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
   
Probe: MGI:5445427
Assay Type: RT-PCR
Annotation Date: 2012-12-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3639222
Stage: TS22
Assay Id: MGI:5445536
Age: embryonic day 14.5
Image: 2
Specimen Label: Wnt4
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
Probe: MGI:7466932
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467160
Age: embryonic day 13.5
Image: 8A Wnt4
Note: Expression is seen in somatic cells.
Specimen Label: 8A Wnt4
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:7466932
Assay Type: Immunohistochemistry
Annotation Date: 2023-04-28
Strength: Present
Sex: Female
Emaps: EMAPS:1796221
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7467160
Age: embryonic day 13.5
Image: 8C Wnt4
Note: Expression is seen in somatic cells.
Specimen Label: 8C Wnt4
Detected: true
Specimen Num: 6
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Publication
18708054 | J:161353
First Author: Nishizuka M
Year: 2008
Journal: FEBS Lett
Title: Wnt4 and Wnt5a promote adipocyte differentiation.
Volume: 582
Issue: 21-22
Pages: 3201-5
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Publication
17505543 | J:129327
First Author: Lee HH
Year: 2007
Journal: PLoS One
Title: Conditional expression of Wnt4 during chondrogenesis leads to dwarfism in mice.
Volume: 2
Issue: 5
Pages: e450
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Protein
P22724
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Protein
Q3ZB23
Organism: Mus musculus/domesticus
Length: 351  
Fragment?: false
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Publication
10967351 | -
First Author: De Ferrari GV
Year: 2000
Journal: Brain Res Brain Res Rev
Title: Wnt signaling function in Alzheimer's disease.
Volume: 33
Issue: 1
Pages: 1-12
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Publication
10733430 | J:60778
First Author: Peifer M
Year: 2000
Journal: Science
Title: Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
Volume: 287
Issue: 5458
Pages: 1606-9
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Publication
9192851 | J:41219
First Author: Semënov MV
Year: 1997
Journal: Genomics
Title: Human dishevelled genes constitute a DHR-containing multigene family.
Volume: 42
Issue: 2
Pages: 302-10
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Publication
10508601 | -
First Author: Bejsovec A
Year: 1999
Journal: Curr Biol
Title: Wnt signalling shows its versatility.
Volume: 9
Issue: 18
Pages: R684-7
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Publication
21536746 | -
First Author: Kestler HA
Year: 2011
Journal: J Cell Biol
Title: Generating a Wnt switch: it's all about the right dosage.
Volume: 193
Issue: 3
Pages: 431-3
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Publication
23027131 | J:196220
First Author: De Menna M
Year: 2013
Journal: Oncogene
Title: Wnt4 inhibits cell motility induced by oncogenic Ras.
Volume: 32
Issue: 35
Pages: 4110-9
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Publication
26321050 | J:226411
First Author: Caprioli A
Year: 2015
Journal: Dev Biol
Title: Wnt4 is essential to normal mammalian lung development.
Volume: 406
Issue: 2
Pages: 222-34
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Publication
15162500 | J:90277
First Author: Yao HH
Year: 2004
Journal: Dev Dyn
Title: Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.
Volume: 230
Issue: 2
Pages: 210-5
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Publication
35764169 | J:327604
First Author: Tlili M
Year: 2022
Journal: J Biol Chem
Title: Cell-intrinsic Wnt4 ligand regulates mitochondrial oxidative phosphorylation in macrophages.
Volume: 298
Issue: 8
Pages: 102193
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Publication
16368682 | J:112694
First Author: Torban E
Year: 2006
Journal: J Biol Chem
Title: PAX2 activates WNT4 expression during mammalian kidney development.
Volume: 281
Issue: 18
Pages: 12705-12
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Publication
25603931 | J:219571
First Author: Rajaram RD
Year: 2015
Journal: EMBO J
Title: Progesterone and Wnt4 control mammary stem cells via myoepithelial crosstalk.
Volume: 34
Issue: 5
Pages: 641-52
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Publication
22705479 | J:188056
First Author: Jameson SA
Year: 2012
Journal: Dev Biol
Title: Testis development requires the repression of Wnt4 by Fgf signaling.
Volume: 370
Issue: 1
Pages: 24-32
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Publication
17050676 | J:114685
First Author: Zhang H
Year: 2006
Journal: Genes Dev
Title: Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
Volume: 20
Issue: 21
Pages: 2943-8
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GXD Expression
GXD Expression
Probe: MGI:2668507
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2668557
Age: embryonic day 12.5
Image: Wnt4 +/+ XY
Note: Expression both in coelomic vessel region and interstitium.
Specimen Label: Wnt4 +/+ XY
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:2668508
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2668558
Age: embryonic day 12.5
Image: Wnt4 +/+ XY
Specimen Label: Wnt4 +/+ XY
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2668507
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2668557
Age: embryonic day 12.5
Image: Wnt4 -/- XX
Note: Expression only associated with ectopic coelomic vessel; not expressed in other interstitial regions.
Specimen Label: Wnt4 -/- XX
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:2668507
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:2668557
Age: embryonic day 12.5
Image: Wnt4 +/+ XX
Specimen Label: Wnt4 +/+ XX
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:2668508
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Absent
Sex: Female
Emaps: EMAPS:1796220
Stage: TS20
Assay Id: MGI:2668558
Age: embryonic day 12.5
Image: Wnt4 +/+ XX
Specimen Label: Wnt4 +/+ XX
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2668508
Assay Type: RNA in situ
Annotation Date: 2003-08-08
Strength: Present
Sex: Female
Emaps: EMAPS:1796220
Pattern: Regionally restricted
Stage: TS20
Assay Id: MGI:2668558
Age: embryonic day 12.5
Image: Wnt4 -/- XX
Note: Expression associated with ectopic coelomic vessel.
Specimen Label: Wnt4 -/- XX
Detected: true
Specimen Num: 4
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Publication
25108526 | J:227599
First Author: Yu B
Year: 2014
Journal: Nat Med
Title: Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB.
Volume: 20
Issue: 9
Pages: 1009-17
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Publication
36448532 | J:331977
 
First Author: Seth A
Year: 2022
Journal: Development
Title: Loss of WNT4 in the gubernaculum causes unilateral cryptorchidism and fertility defects.
Volume: 149
Issue: 23
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Publication
19830824 | J:154784
First Author: Shan J
Year: 2009
Journal: Genesis
Title: Generation of an allele to inactivate Wnt4 gene function conditionally in the mouse.
Volume: 47
Issue: 11
Pages: 782-8
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Publication
37000005 | J:338879
First Author: Hernández-García A
Year: 2023
Journal: Hum Mol Genet
Title: SOX7 deficiency causes ventricular septal defects through its effects on endocardial-to-mesenchymal transition and the expression of Wnt4 and Bmp2.
Volume: 32
Issue: 13
Pages: 2152-2161
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Publication
33441379 | J:300978
 
First Author: Jorgez CJ
Year: 2021
Journal: Development
Title: E2F1 regulates testicular descent and controls spermatogenesis by influencing WNT4 signaling.
Volume: 148
Issue: 1
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Publication
36271049 | J:330537
First Author: Katsumoto K
Year: 2022
Journal: Nat Commun
Title: Wnt4 is heterogeneously activated in maturing β-cells to control calcium signaling, metabolism and function.
Volume: 13
Issue: 1
Pages: 6255
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Publication
18617424 | J:137842
First Author: Louis I
Year: 2008
Journal: Immunity
Title: The signaling protein Wnt4 enhances thymopoiesis and expands multipotent hematopoietic progenitors through beta-catenin-independent signaling.
Volume: 29
Issue: 1
Pages: 57-67
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Publication
31175162 | J:278507
First Author: Hung LY
Year: 2019
Journal: J Immunol
Title: Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity.
Volume: 203
Issue: 2
Pages: 511-519
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Publication
31495781 | J:294960
First Author: Eliazer S
Year: 2019
Journal: Cell Stem Cell
Title: Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells.
Volume: 25
Issue: 5
Pages: 654-665.e4
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Publication
20371632 | J:162337
First Author: Boyer A
Year: 2010
Journal: FASEB J
Title: WNT4 is required for normal ovarian follicle development and female fertility.
Volume: 24
Issue: 8
Pages: 3010-25
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Publication
16700629 | J:110252
First Author: Kim Y
Year: 2006
Journal: PLoS Biol
Title: Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination.
Volume: 4
Issue: 6
Pages: e187
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Publication
15581876 | J:106304
First Author: Jeays-Ward K
Year: 2004
Journal: Dev Biol
Title: Wnt4 is required for proper male as well as female sexual development.
Volume: 276
Issue: 2
Pages: 431-40
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Publication
12475749 | J:82999
First Author: Surendran K
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury.
Volume: 284
Issue: 4
Pages: F653-62
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Publication
24036309 | J:203797
First Author: Maatouk DM
Year: 2013
Journal: Dev Biol
Title: Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
Volume: 383
Issue: 2
Pages: 295-306
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Publication
15964998 | J:99154
First Author: Devgan V
Year: 2005
Journal: Genes Dev
Title: p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation.
Volume: 19
Issue: 12
Pages: 1485-95
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Publication
17728319 | J:129972
First Author: Ottolenghi C
Year: 2007
Journal: Hum Mol Genet
Title: Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells.
Volume: 16
Issue: 23
Pages: 2795-804
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Publication
21541287 | J:172379
First Author: Heinonen KM
Year: 2011
Journal: PLoS One
Title: Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway.
Volume: 6
Issue: 4
Pages: e19279
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Publication
12835383 | J:84602
First Author: Jeays-Ward K
Year: 2003
Journal: Development
Title: Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad.
Volume: 130
Issue: 16
Pages: 3663-70
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Publication
37155872 | J:338020
First Author: Okashita N
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: CDYL reinforces male gonadal sex determination through epigenetically repressing Wnt4 transcription in mice.
Volume: 120
Issue: 20
Pages: e2221499120
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Publication
21937690 | J:178890
First Author: Heinonen KM
Year: 2011
Journal: Blood
Title: Wnt4 regulates thymic cellularity through the expansion of thymic epithelial cells and early thymic progenitors.
Volume: 118
Issue: 19
Pages: 5163-73
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Publication
32365547 | J:305205
 
First Author: Tang F
Year: 2020
Journal: Cells
Title: Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9.
Volume: 9
Issue: 5
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Publication
23095882 | J:189064
First Author: Chassot AA
Year: 2012
Journal: Development
Title: WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonad.
Volume: 139
Issue: 23
Pages: 4461-72
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Publication
18346943 | J:133949
First Author: Valerius MT
Year: 2008
Journal: Gene Expr Patterns
Title: Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation.
Volume: 8
Issue: 5
Pages: 297-306
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Publication
19740593 | J:173153
First Author: Shan J
Year: 2010
Journal: Differentiation
Title: Mapping of the fate of cell lineages generated from cells that express the Wnt4 gene by time-lapse during kidney development.
Volume: 79
Issue: 1
Pages: 57-64
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Publication
30010727 | J:270008
First Author: St-Jean G
Year: 2019
Journal: Biol Reprod
Title: Targeted ablation of Wnt4 and Wnt5a in Müllerian duct mesenchyme impedes endometrial gland development and causes partial Müllerian agenesis.
Volume: 100
Issue: 1
Pages: 49-60
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Publication
22465478 | J:187132
First Author: Murugan S
Year: 2012
Journal: Exp Cell Res
Title: WT1 and Sox11 regulate synergistically the promoter of the Wnt4 gene that encodes a critical signal for nephrogenesis.
Volume: 318
Issue: 10
Pages: 1134-45
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Publication
12949260 | J:85499
First Author: Jordan BK
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnt4 overexpression disrupts normal testicular vasculature and inhibits testosterone synthesis by repressing steroidogenic factor 1/beta-catenin synergy.
Volume: 100
Issue: 19
Pages: 10866-71
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Publication
26721931 | J:229475
First Author: Prunskaite-Hyyryläinen R
Year: 2016
Journal: Hum Mol Genet
Title: Wnt4 coordinates directional cell migration and extension of the Müllerian duct essential for ontogenesis of the female reproductive tract.
Volume: 25
Issue: 6
Pages: 1059-73
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Publication
21852398 | J:176046
First Author: Boyle SC
Year: 2011
Journal: Development
Title: Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.
Volume: 138
Issue: 19
Pages: 4245-54
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Publication
10654605 | J:53153
First Author: Lee CS
Year: 2000
Journal: Development
Title: SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm.
Volume: 127
Issue: 1
Pages: 109-18
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GXD Expression
GXD Expression
Probe: MGI:1206541
Assay Type: RNA in situ
Annotation Date: 1998-11-27
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1310072
Age: postnatal adult
Image: 8 unpregnant +/+
Note: Wnt4 is expressed in the mesenchyme surrounding the luminal epithelium.
Specimen Label: 8 unpregnant +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
16844427 | J:116022
First Author: Coveney D
Year: 2007
Journal: Gene Expr Patterns
Title: A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation.
Volume: 7
Issue: 1-2
Pages: 82-92
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689419
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:6191570
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Wnt4
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Not Specified
Stage: TS21
Assay Id: MGI:6191570
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Wnt4
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191570
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Wnt4
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191570
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Wnt4
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191570
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Wnt4
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191570
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Wnt4
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:6186871
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191570
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Wnt4
Detected: true
Specimen Num: 7
•
•
•
•
•
Publication
12554773 | J:162151
First Author: Mizusaki H
Year: 2003
Journal: Mol Endocrinol
Title: Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad.
Volume: 17
Issue: 4
Pages: 507-19
•
•
•
•
•
Publication
17711857 | J:126765
First Author: Li Q
Year: 2007
Journal: J Biol Chem
Title: Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human.
Volume: 282
Issue: 43
Pages: 31725-32
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4838226
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2813623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540704
Age: embryonic day 15.5
Image: GUDMAP:7156
Note: restricted to a subset of cells immediately surrounding the collecting ducts for Wnt4 RNA
Specimen Label: GUDMAP:7156
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4838226
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1832623
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5540704
Age: embryonic day 15.5
Image: GUDMAP:7156
Note: restricted to a subset of cells immediately surrounding the collecting ducts for Wnt4 RNA
Specimen Label: GUDMAP:7156
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4838226
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2776423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:5540704
Age: embryonic day 15.5
Image: GUDMAP:8209
Note: Wnt4 signal in a subset of cells closest to medial segment which overlap with W1 protein
Specimen Label: GUDMAP:8209
Detected: true
Specimen Num: 9
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:1206541
Assay Type: RNA in situ
Annotation Date: 1998-11-27
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:1310072
Age: postnatal adult
Image: 8 unpregnant -/-
Note: Wnt4 expression is absent from the subluminal mesenchyme, but is instead expressed specifically within the endometrial epithelium.
Specimen Label: 8 unpregnant -/-
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4838226
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:2891420
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540704
Age: embryonic day 12.5
Image: GUDMAP:7158
Note: Wnt4 signal was strongest at the junction where it contacts the ovary and two lines of signal in the mesonephric mesenchyme running medial to and parallel to the nephric duct and paramesonephric duct.
Specimen Label: GUDMAP:7158
Detected: true
Specimen Num: 4
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4838226
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2914320
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:5540704
Age: embryonic day 12.5
Image: GUDMAP:7157
Note: Wnt4 signal was strongest at the junction where it contacts the ovary and two lines of signal in the mesonephric mesenchyme running medial to and parallel to the nephric duct and paramesonephric duct.
Specimen Label: GUDMAP:7157
Detected: true
Specimen Num: 3
•
•
•
•
•
Publication
29449451 | J:296649
First Author: Lindström NO
Year: 2018
Journal: J Am Soc Nephrol
Title: Conserved and Divergent Molecular and Anatomic Features of Human and Mouse Nephron Patterning.
Volume: 29
Issue: 3
Pages: 825-840
•
•
•
•
•
Publication
37727504 | J:340740
 
First Author: Xu J
Year: 2023
Journal: Front Cell Dev Biol
Title: Smarca4 deficiency induces Pttg1 oncogene upregulation and hyperproliferation of tubular and interstitial cells during kidney development.
Volume: 11
Pages: 1233317
•
•
•
•
•
Publication
29377931 | J:264647
First Author: O'Brien LL
Year: 2018
Journal: PLoS Genet
Title: Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies.
Volume: 14
Issue: 1
Pages: e1007181
•
•
•
•
•
DO Term
DOID:0111526 | Mullerian aplasia and hyperandrogenism
•
•
•
•
•
Publication
24744442 | J:267799
First Author: Kanda S
Year: 2014
Journal: J Am Soc Nephrol
Title: Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.
Volume: 25
Issue: 11
Pages: 2584-95
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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