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Search results 1 to 100 out of 1071 for Wnt9b

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0.039s
Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: zebrafish
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Gene
Type: gene
Organism: chimpanzee
Protein Domain
Type: Family
Description: Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) []. It is now recognised that Wnt signalling controls many cell fate decisions in a variety of different organisms, including mammals []. Wnt signalling has been implicated in tumourigenesis, early mesodermal patterning of the embryo, morphogenesis of the brain and kidneys, regulation of mammary gland proliferation and Alzheimer's disease [, ].Wnt-mediated signalling is believed to proceed initially through binding to cell surface receptors of the frizzled family; the signal is subsequently transduced through several cytoplasmic components to B-catenin, which enters the nucleus and activates the transcription of several genes important indevelopment []. Several non-canonical Wnt signalling pathways have also been elucidated that act independently of B-catenin. Canonical and noncanonical Wnt signaling branches are highly interconnected, and cross-regulate each other [].Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. They encode proteins of ~350-400 residues in length, with orthologues identified in several, mostly vertebrate, species. Very little is known about the structure of Wnts as they are notoriously insoluble, but they share the following features characteristics of secretory proteins: a signal peptide, several potential N-glycosylation sites and 22 conserved cysteines []that are probably involved in disulphide bonds. The Wnt proteins seem to adhere to the plasma membrane of the secretingcells and are therefore likely to signal over only few cell diameters. Fifteen major Wnt gene families have been identified in vertebrates, with multiple subtypes within some classes.This entry represents Wnt-9b. Human Wnt-9a (previously Wnt-14) maps to chromosome 1 and originates, together with Wnt-9b (previously Wnt-15), from an ancestral branch of the Wnt gene family, which includes the Wnt-9 sequences found in jawless and cartilaginous fishes [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Bergstein I
Year: 1997
Journal: Genomics
Title: Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.
Volume: 46
Issue: 3
Pages: 450-8
Publication
First Author: Qian J
Year: 2003
Journal: Genomics
Title: Mouse Wnt9b transforming activity, tissue-specific expression, and evolution.
Volume: 81
Issue: 1
Pages: 34-46
Publication
First Author: Karner CM
Year: 2009
Journal: Nat Genet
Title: Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.
Volume: 41
Issue: 7
Pages: 793-9
Publication
First Author: Dickinson KK
Year: 2019
Journal: PLoS One
Title: Molecular determinants of WNT9b responsiveness in nephron progenitor cells.
Volume: 14
Issue: 4
Pages: e0215139
Publication
First Author: Boivin FJ
Year: 2015
Journal: PLoS One
Title: Stromally expressed β-catenin modulates Wnt9b signaling in the ureteric epithelium.
Volume: 10
Issue: 3
Pages: e0120347
Publication
First Author: Juriloff DM
Year: 2006
Journal: Birth Defects Res A Clin Mol Teratol
Title: Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test.
Volume: 76
Issue: 8
Pages: 574-9
Publication
First Author: Karner CM
Year: 2011
Journal: Development
Title: Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
Volume: 138
Issue: 7
Pages: 1247-57
Publication
First Author: Kiefer SM
Year: 2012
Journal: PLoS One
Title: Conditional expression of Wnt9b in Six2-positive cells disrupts stomach and kidney function.
Volume: 7
Issue: 8
Pages: e43098
Publication
First Author: Lan Y
Year: 2006
Journal: Dev Dyn
Title: Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.
Volume: 235
Issue: 5
Pages: 1448-54
Protein
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
Publication  
First Author: Wodarz A
Year: 1998
Journal: Annu Rev Cell Dev Biol
Title: Mechanisms of Wnt signaling in development.
Volume: 14
Pages: 59-88
Publication
First Author: De Ferrari GV
Year: 2000
Journal: Brain Res Brain Res Rev
Title: Wnt signaling function in Alzheimer's disease.
Volume: 33
Issue: 1
Pages: 1-12
Publication
First Author: Peifer M
Year: 2000
Journal: Science
Title: Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.
Volume: 287
Issue: 5458
Pages: 1606-9
Publication
First Author: Semënov MV
Year: 1997
Journal: Genomics
Title: Human dishevelled genes constitute a DHR-containing multigene family.
Volume: 42
Issue: 2
Pages: 302-10
Publication
First Author: Bejsovec A
Year: 1999
Journal: Curr Biol
Title: Wnt signalling shows its versatility.
Volume: 9
Issue: 18
Pages: R684-7
Publication
First Author: Kestler HA
Year: 2011
Journal: J Cell Biol
Title: Generating a Wnt switch: it's all about the right dosage.
Volume: 193
Issue: 3
Pages: 431-3
Publication  
First Author: Jin YR
Year: 2020
Journal: Front Cell Dev Biol
Title: Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice.
Volume: 8
Pages: 264
Publication
First Author: Carroll TJ
Year: 2005
Journal: Dev Cell
Title: Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.
Volume: 9
Issue: 2
Pages: 283-92
Publication
First Author: Boyle SC
Year: 2011
Journal: Development
Title: Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.
Volume: 138
Issue: 19
Pages: 4245-54
GXD Expression      
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689419
Stage: TS19
Assay Id: MGI:6191577
Age: embryonic day 11.5
Specimen Label: Table S2 - E11.5 - Wnt9b
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:6191577
Age: embryonic day 15.5
Specimen Label: Table S2 - E15.5 - Wnt9b
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689426
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6191577
Age: embryonic day 18.5
Specimen Label: Table S2 - E18.5 - Wnt9b
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191577
Age: postnatal day 14
Specimen Label: Table S2 - P14 - Wnt9b
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191577
Age: postnatal day 28
Specimen Label: Table S2 - P28 - Wnt9b
Detected: true
Specimen Num: 7
GXD Expression      
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689421
Stage: TS21
Assay Id: MGI:6191577
Age: embryonic day 13.5
Specimen Label: Table S2 - E13.5 - Wnt9b
Detected: false
Specimen Num: 2
GXD Expression    
Probe: MGI:6186892
Assay Type: RNA in situ
Annotation Date: 2018-07-25
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6191577
Age: postnatal day 4
Specimen Label: Table S2 - P4 - Wnt9b
Detected: true
Specimen Num: 5
Publication
First Author: Reutter H
Year: 2014
Journal: Hum Mol Genet
Title: Genome-wide association study and mouse expression data identify a highly conserved 32 kb intergenic region between WNT3 and WNT9b as possible susceptibility locus for isolated classic exstrophy of the bladder.
Volume: 23
Issue: 20
Pages: 5536-44
Publication
First Author: Juriloff DM
Year: 2005
Journal: Birth Defects Res A Clin Mol Teratol
Title: Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice.
Volume: 73
Issue: 2
Pages: 103-13
Publication
First Author: Juriloff DM
Year: 2004
Journal: Birth Defects Res A Clin Mol Teratol
Title: A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci.
Volume: 70
Issue: 8
Pages: 509-18
Publication  
First Author: Juriloff DM
Year: 1986
Journal: J Craniofac Genet Dev Biol Suppl
Title: Major genes that cause cleft lip in mice: progress in the construction of a congenic strain and in linkage mapping.
Volume: 2
Pages: 55-66
Publication
First Author: Juriloff DM
Year: 1995
Journal: J Craniofac Genet Dev Biol
Title: Genetic analysis of the construction of the AEJ.A congenic strain indicates that nonsyndromic CL(P) in the mouse is caused by two loci with epistatic interaction.
Volume: 15
Issue: 1
Pages: 1-12
Publication
First Author: Sasaki Y
Year: 2014
Journal: Congenit Anom (Kyoto)
Title: Molecular contribution to cleft palate production in cleft lip mice.
Volume: 54
Issue: 2
Pages: 94-9
Publication
First Author: Nakazawa M
Year: 2008
Journal: Scand J Plast Reconstr Surg Hand Surg
Title: Molecular mechanisms of cleft lip formation in CL/Fr mice.
Volume: 42
Issue: 5
Pages: 225-32
Publication
First Author: Juriloff DM
Year: 2001
Journal: Mamm Genome
Title: Unravelling the complex genetics of cleft lip in the mouse model.
Volume: 12
Issue: 6
Pages: 426-35
Publication
First Author: Trasler DG
Year: 1982
Journal: Teratology
Title: Mitotic index in mouse embryos with 6-aminonicotinamide-induced and inherited cleft lip.
Volume: 25
Issue: 2
Pages: 259-65
Publication
First Author: Kobayashi A
Year: 2008
Journal: Cell Stem Cell
Title: Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development.
Volume: 3
Issue: 2
Pages: 169-81
Publication
First Author: Ramalingam H
Year: 2018
Journal: Dev Biol
Title: Disparate levels of beta-catenin activity determine nephron progenitor cell fate.
Volume: 440
Issue: 1
Pages: 13-21
Publication
First Author: Nowialis P
Year: 2019
Journal: Nat Commun
Title: Catalytically inactive Dnmt3b rescues mouse embryonic development by accessory and repressive functions.
Volume: 10
Issue: 1
Pages: 4374
Publication
First Author: Goddard LM
Year: 2017
Journal: Dev Cell
Title: Hemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Volume: 43
Issue: 3
Pages: 274-289.e5
Publication
First Author: Jin YR
Year: 2012
Journal: Development
Title: Wnt9b-dependent FGF signaling is crucial for outgrowth of the nasal and maxillary processes during upper jaw and lip development.
Volume: 139
Issue: 10
Pages: 1821-30
Publication
First Author: Das A
Year: 2013
Journal: Nat Cell Biol
Title: Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
Volume: 15
Issue: 9
Pages: 1035-44
Publication
First Author: Kiefer SM
Year: 2010
Journal: Development
Title: Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development.
Volume: 137
Issue: 18
Pages: 3099-106
Publication
First Author: Park JS
Year: 2007
Journal: Development
Title: Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development.
Volume: 134
Issue: 13
Pages: 2533-9
Publication
First Author: Chiga M
Year: 2014
Journal: Int J Dev Biol
Title: Preformed Wolffian duct regulates Müllerian duct elongation independently of canonical Wnt signaling or Lhx1 expression.
Volume: 58
Issue: 9
Pages: 663-8
Publication
First Author: Bourhis E
Year: 2010
Journal: J Biol Chem
Title: Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.
Volume: 285
Issue: 12
Pages: 9172-9
Publication
First Author: Alfieri CM
Year: 2010
Journal: Dev Biol
Title: Wnt signaling in heart valve development and osteogenic gene induction.
Volume: 338
Issue: 2
Pages: 127-35
Publication
First Author: Pedersen A
Year: 2005
Journal: Dev Biol
Title: Lim 1 is required for nephric duct extension and ureteric bud morphogenesis.
Volume: 288
Issue: 2
Pages: 571-81
Publication
First Author: Gai Z
Year: 2009
Journal: J Am Soc Nephrol
Title: Trps1 functions downstream of Bmp7 in kidney development.
Volume: 20
Issue: 11
Pages: 2403-11
Publication  
First Author: Hilliard SA
Year: 2020
Journal: Mech Dev
Title: Mdm4 controls ureteric bud branching via regulation of p53 activity.
Volume: 163
Pages: 103616
Publication
First Author: Lokmane L
Year: 2010
Journal: Development
Title: vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis.
Volume: 137
Issue: 2
Pages: 347-57
Publication  
First Author: Li H
Year: 2021
Journal: Development
Title: Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.
Volume: 148
Issue: 10
Publication
First Author: Trowe MO
Year: 2012
Journal: Development
Title: Canonical Wnt signaling regulates smooth muscle precursor development in the mouse ureter.
Volume: 139
Issue: 17
Pages: 3099-108
Publication
First Author: Jia S
Year: 2020
Journal: Dev Dyn
Title: Pax9's dual roles in modulating Wnt signaling during murine palatogenesis.
Volume: 249
Issue: 10
Pages: 1274-1284
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kirikoshi H
Year: 2002
Journal: Int J Mol Med
Title: Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11.
Volume: 9
Issue: 2
Pages: 135-9
Publication  
First Author: Biddle FG
Year: 1986
Journal: J Craniofac Genet Dev Biol Suppl
Title: Major gene determination of liability to spontaneous cleft lip in the mouse.
Volume: 2
Pages: 67-88
Publication
First Author: Juriloff DM
Year: 1993
Journal: J Craniofac Genet Dev Biol
Title: Current status of genetic linkage studies of a major gene that causes CL(P) in mice: exclusion map.
Volume: 13
Issue: 4
Pages: 223-9
Publication
First Author: Amin N
Year: 1994
Journal: Cleft Palate Craniofac J
Title: Alterations in vascular pattern of the developing palate in normal and spontaneous cleft palate mouse embryos.
Volume: 31
Issue: 5
Pages: 332-44
Publication
First Author: Juriloff DM
Year: 1995
Journal: Mamm Genome
Title: The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11.
Volume: 6
Issue: 2
Pages: 63-9
Publication
First Author: Juriloff DM
Year: 1996
Journal: Mamm Genome
Title: The clf1 gene maps to a 2- to 3-cM region of distal mouse chromosome 11.
Volume: 7
Issue: 10
Pages: 789
Publication
First Author: Nagata M
Year: 1997
Journal: Cleft Palate Craniofac J
Title: Isolated maxillary bending in CL/FR strain mice: observation of craniofacial deformity and inheritance pattern.
Volume: 34
Issue: 2
Pages: 101-5
GXD Expression        
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Heart
Specimen Num: 2
GXD Expression      
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Brain
Detected: true
Specimen Num: 3
GXD Expression        
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Spleen
Specimen Num: 4
GXD Expression        
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Lung
Specimen Num: 5
GXD Expression      
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Liver
Detected: true
Specimen Num: 6
GXD Expression        
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Skeletal Muscle
Specimen Num: 7
GXD Expression      
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Kidney
Detected: true
Specimen Num: 8
GXD Expression        
Probe: MGI:2661934
Assay Type: RT-PCR
Annotation Date: 2003-06-03
Strength: Not Specified
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:2661939
Age: postnatal adult
Specimen Label: Testis
Specimen Num: 9