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Search results 1 to 100 out of 104 for Xirp2

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0.054s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: Proteins in this family contains Xin repeats, which define an actin-binding motif. In humans two Xin-repeat proteins have been identified, XIRP1 and XIRP2. They are expressed during early developmental stages of cardiac and skeletal muscles []and have an important role in cardiac development and function []. They bind to and stabilise F-actin [].This entry represents XIRP2, also known as Xin-beta. In mouse, it initiates the maturation of the intercalated discs (ICDs)during postnatal heart development [].
Publication
First Author: Wang Q
Year: 2013
Journal: Dev Biol
Title: The Xin repeat-containing protein, mXinβ, initiates the maturation of the intercalated discs during postnatal heart development.
Volume: 374
Issue: 2
Pages: 264-80
Gene
Type: gene
Organism: Homo sapiens
Protein
Organism: Mus musculus
Length: 3784  
Fragment?: false
Protein
Organism: Mus musculus
Length: 67  
Fragment?: true
Protein
Organism: Mus musculus
Length: 374  
Fragment?: true
Protein
Organism: Mus musculus
Length: 118  
Fragment?: true
Protein
Organism: Mus musculus
Length: 101  
Fragment?: true
Publication
First Author: van der Ven PF
Year: 2006
Journal: Exp Cell Res
Title: Unusual splicing events result in distinct Xin isoforms that associate differentially with filamin c and Mena/VASP.
Volume: 312
Issue: 11
Pages: 2154-67
Publication
First Author: Pacholsky D
Year: 2004
Journal: J Cell Sci
Title: Xin repeats define a novel actin-binding motif.
Volume: 117
Issue: Pt 22
Pages: 5257-68
Publication  
First Author: Wang Q
Year: 2014
Journal: Int Rev Cell Mol Biol
Title: New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease.
Volume: 310
Pages: 89-128
Publication
First Author: Scheffer DI
Year: 2015
Journal: Cell Rep
Title: XIRP2, an actin-binding protein essential for inner ear hair-cell stereocilia.
Volume: 10
Issue: 11
Pages: 1811-8
Publication
First Author: Francis SP
Year: 2015
Journal: J Neurosci
Title: A short splice form of Xin-actin binding repeat containing 2 (XIRP2) lacking the Xin repeats is required for maintenance of stereocilia morphology and hearing function.
Volume: 35
Issue: 5
Pages: 1999-2014
Publication  
First Author: Huang L
Year: 2018
Journal: J Am Heart Assoc
Title: Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population.
Volume: 7
Issue: 1
Publication
First Author: McCalmon SA
Year: 2010
Journal: Circ Res
Title: Modulation of angiotensin II-mediated cardiac remodeling by the MEF2A target gene Xirp2.
Volume: 106
Issue: 5
Pages: 952-60
Publication
First Author: Leber Y
Year: 2016
Journal: Hum Mol Genet
Title: Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.
Volume: 25
Issue: 13
Pages: 2776-2788
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Wang Q
Year: 2010
Journal: Circ Res
Title: Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival.
Volume: 106
Issue: 9
Pages: 1468-78
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1672828
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: false
Specimen Num: 2
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: false
Specimen Num: 3
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737328
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: false
Specimen Num: 7
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3598828
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: true
Specimen Num: 6
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: false
Specimen Num: 5
GXD Expression      
Probe: MGI:5691551
Assay Type: Northern blot
Annotation Date: 2015-10-15
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5691552
Age: postnatal adult
Detected: false
Specimen Num: 8
Publication
First Author: Huang HT
Year: 2006
Journal: J Biol Chem
Title: Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.
Volume: 281
Issue: 51
Pages: 39370-9
Publication
First Author: Jung-Ching Lin J
Year: 2005
Journal: J Med Sci
Title: Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin.
Volume: 25
Issue: 5
Pages: 215-222
Publication
First Author: Grosskurth SE
Year: 2008
Journal: PLoS One
Title: Emergence of Xin demarcates a key innovation in heart evolution.
Volume: 3
Issue: 8
Pages: e2857
Publication
First Author: Tran PV
Year: 2008
Journal: Nat Genet
Title: THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia.
Volume: 40
Issue: 4
Pages: 403-410
Publication
First Author: Lamberti A
Year: 2011
Journal: Biochimie
Title: Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics.
Volume: 93
Issue: 10
Pages: 1738-46
Publication
First Author: Gustafson-Wagner EA
Year: 2007
Journal: Am J Physiol Heart Circ Physiol
Title: Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects.
Volume: 293
Issue: 5
Pages: H2680-92
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication      
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
Publication
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication          
First Author: MGD Nomenclature Committee
Year: 1995
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics, the Protein Information Resource and the Protein Ontology Consortium
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Allele
Name: xin actin-binding repeat containing 2; targeted mutation 1, inGenious Targeting Laboratory
Allele Type: Targeted
Attribute String: Conditional ready, Hypomorph
Publication categories: ProxyCollection
Allele
Name: xin actin-binding repeat containing 2; targeted mutation 1.1, inGenious Targeting Laboratory
Allele Type: Targeted
Attribute String: Hypomorph
Publication categories: ProxyCollection
Publication
First Author: Ottenheijm CA
Year: 2010
Journal: Physiology (Bethesda)
Title: Lifting the nebula: novel insights into skeletal muscle contractility.
Volume: 25
Issue: 5
Pages: 304-10
Publication
First Author: Chu M
Year: 2016
Journal: J Exp Biol
Title: Nebulin, a multi-functional giant.
Volume: 219
Issue: Pt 2
Pages: 146-52
Publication
First Author: Carroll S
Year: 2004
Journal: J Cell Sci
Title: N-RAP scaffolds I-Z-I assembly during myofibrillogenesis in cultured chick cardiomyocytes.
Volume: 117
Issue: Pt 1
Pages: 105-14
Publication
First Author: Carroll SL
Year: 2001
Journal: J Cell Sci
Title: Targeting and functional role of N-RAP, a nebulin-related LIM protein, during myofibril assembly in cultured chick cardiomyocytes.
Volume: 114
Issue: Pt 23
Pages: 4229-38
Protein Domain
Type: Family
Description: This entry include nebulin and nebulin-related-anchoring protein (N-RAP). Nebulin is a giant filamentous protein (600-900 kD) that plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly in skeletal muscle. It contains an N-terminal LIM domain, many nebulin repeats/super repeats, and a C-terminal SH3 domain. The N terminus of nebulin is located near the pointed end of the thin filament and contains a binding site for the actin filament capping protein tropomodulin (Tmod). The super repeat region of nebulin has been shown to interact with kelch-like family member 40 (KLHL40). The C terminus of nebulin is located within the highly specialized boundary of the sarcomere (Z-disc), and plays an important role in myofibril assembly, mechanosensing, signaling, force generation and transmission, and sarcolemmal resilience. The SH3 domain of nebulin interacts with multiple proteins, such as alpha-actinin, XIRP2 and titin []. Mutations in nebulin can cause nemaline myopathy, characterised by muscle weakness which can be severe and can lead to neonatal lethality []. Nebulin-related-anchoring protein (N-RAP) is a muscle-specific protein that may serve as a scaffold for premyofibril assembly [, ]. N-RAP contains a N-terminal LIM domain (LIM), the C-terminal actin-binding nebulin super repeats and the nebulin-related simple repeats (IB) in between the two []. The N-terminal IB region is essential for alpha-actinin organisation, while the N-RAP super repeats are essential for sarcomeric actin organisation [].
Protein Domain
Type: Domain
Description: Nebulin is a giant filamentous protein (600-900 kD) that plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly in skeletal muscle. It contains an N-terminal LIM domain, many nebulin repeats/super repeats, and a C-terminal SH3 domain. The N terminus of nebulin is located near the pointed end of the thin filament and contains a binding site for the actin filament capping protein tropomodulin (Tmod). The super repeat region of nebulin has been shown to interact with kelch-like family member 40 (KLHL40). The C terminus of nebulin is located within the highly specialized boundary of the sarcomere (Z-disc), and plays an important role in myofibril assembly, mechanosensing, signaling, force generation and transmission, and sarcolemmal resilience. The SH3 domain of nebulin interacts with multiple proteins, such as alpha-actinin, XIRP2 and titin []. Mutations in nebulin can cause nemaline myopathy, characterised by muscle weakness which can be severe and can lead to neonatal lethality []. This entry represents the SH3 domain of Nebulin.
Publication
First Author: Lu S
Year: 2003
Journal: J Cell Sci
Title: New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.
Volume: 116
Issue: Pt 11
Pages: 2169-78
Protein
Organism: Mus musculus
Length: 354  
Fragment?: true
Protein
Organism: Mus musculus
Length: 424  
Fragment?: true
Protein
Organism: Mus musculus
Length: 342  
Fragment?: true
Protein
Organism: Mus musculus
Length: 387  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1190  
Fragment?: true
Protein
Organism: Mus musculus
Length: 269  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1358  
Fragment?: true
Protein
Organism: Mus musculus
Length: 1190  
Fragment?: true
Protein
Organism: Mus musculus
Length: 6909  
Fragment?: false
Protein
Organism: Mus musculus
Length: 7152  
Fragment?: false
Protein
Organism: Mus musculus
Length: 3044  
Fragment?: false
Protein
Organism: Mus musculus
Length: 768  
Fragment?: true