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Search results 1 to 86 out of 86 for Xkr8

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Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
55113 | XKR8
Type: gene
Organism: human
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Gene
619360 | xkr8
Type: gene
Organism: frog, western clawed
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Gene
313033 | Xkr8
Type: gene
Organism: rat
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Gene
613218 | XKR8
Type: gene
Organism: chimpanzee
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Gene
514365 | XKR8
Type: gene
Organism: cattle
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Gene
100855772 | XKR8
Type: gene
Organism: dog, domestic
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Gene
724081 | XKR8
Type: gene
Organism: chicken
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Gene
716692 | XKR8
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2685877 | Xkr8
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30718401 | J:306596
First Author: Sakuragi T
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation-mediated activation of mouse Xkr8 scramblase for phosphatidylserine exposure.
Volume: 116
Issue: 8
Pages: 2907-2912
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Publication
37211968 | J:338439
First Author: Neniskyte U
Year: 2023
Journal: EMBO J
Title: Phospholipid scramblase Xkr8 is required for developmental axon pruning via phosphatidylserine exposure.
Volume: 42
Issue: 14
Pages: e111790
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Publication
37101210 | J:344898
First Author: Chen K
Year: 2023
Journal: J Transl Med
Title: A dominant variant in apoptosis-related gene XKR8 is relevant to hereditary auditory neuropathy.
Volume: 21
Issue: 1
Pages: 279
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Publication
30559640 | J:273974
 
First Author: Kautzman AG
Year: 2018
Journal: Front Neurosci
Title: Xkr8 Modulates Bipolar Cell Number in the Mouse Retina.
Volume: 12
Pages: 876
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Publication
23845944 | J:199440
First Author: Suzuki J
Year: 2013
Journal: Science
Title: Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells.
Volume: 341
Issue: 6144
Pages: 403-6
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Publication
28881496 | J:317385
First Author: Kim GW
Year: 2017
Journal: FEBS J
Title: Xk-related protein 8 regulates myoblast differentiation and survival.
Volume: 284
Issue: 21
Pages: 3575-3588
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Publication
29440417 | J:265778
First Author: Kawano M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Lupus-like autoimmune disease caused by a lack of Xkr8, a caspase-dependent phospholipid scramblase.
Volume: 115
Issue: 9
Pages: 2132-2137
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Publication
31712393 | J:293092
 
First Author: Yamashita Y
Year: 2020
Journal: Mol Cell Biol
Title: Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8-Deficient Male Mice.
Volume: 40
Issue: 3
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Publication
25231987 | J:306586
First Author: Suzuki J
Year: 2014
Journal: J Biol Chem
Title: Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.
Volume: 289
Issue: 44
Pages: 30257-67
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Protein Coding Gene
MGP_CAROLIEiJ_G0026572 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0028877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0028836 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0028789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0028859 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028573 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2685877 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029301 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028006 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028688 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028655 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0028789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028681 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029339 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027727 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028086 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0028905 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027553 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27503893 | J:235607
First Author: Suzuki J
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.
Volume: 113
Issue: 34
Pages: 9509-14
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Publication
36323258 | J:333431
First Author: Wang W
Year: 2022
Journal: Cell Rep
Title: Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Volume: 41
Issue: 5
Pages: 111582
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Protein
Q5GH64
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q5GH67
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Protein
Q5GH68
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: false
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Protein
Q5GH66
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
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Protein
Q9QXY7
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
E9Q6C8
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: false
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Protein
Q5GH62
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
Q8C0T0
Organism: Mus musculus/domesticus
Length: 401  
Fragment?: false
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Protein
Q8BG78
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q0VFY4
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
Q8C9P4
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
B2RY73
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
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Protein
D6RIN5
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
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Protein
H3BL12
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
H3BJG3
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
Q059K7
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Publication
8004674 | -
First Author: Ho M
Year: 1994
Journal: Cell
Title: Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.
Volume: 77
Issue: 6
Pages: 869-80
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Publication
7737196 | -
First Author: Khamlichi S
Year: 1995
Journal: Eur J Biochem
Title: Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients.
Volume: 228
Issue: 3
Pages: 931-4
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Publication
32845802 | -
First Author: Park JS
Year: 2020
Journal: Mol Biol Cell
Title: XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome.
Volume: 31
Issue: 22
Pages: 2425-2436
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Protein Domain
IPR018629 | XK-rel
Type: Family
Description: This family is represented by the multipass membrane protein XK, which may be involved in sodium-dependent transport of neutral amino acids or oligopeptides. It forms a heterodimer with Kell. In humans, Kell is an 93kDa type II membrane glycoprotein with endothelin-3-converting enzyme activity that is linked by a single disulphide bond to XK, that spans the membrane ten times. An absence of XK leads to clinical symptoms termed the McLeod syndrome , an X-linked multi-system disorder characterised by late onset abnormalities in the neuromuscular and hematopoietic systems [, ]. It has been shown that XK recruits the lipid transfer protein VPS13A from lipid droplets to the endoplasmic reticulum (ER) membrane and dysregulation of a VPS13A-XK complex is the common basis for Chorea-Acanthocytosis and McLeod Syndrome []. The human and mouse Xk-related (Xkr) families consist of nine and eight members, respectively, and mutations or variations in the gene of Xkr members are associated to human diseases. Xkr8 and other members of the family promote phosphatidylserine exposure in apoptotic cells [, , ].
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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