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Search results 1 to 100 out of 373 for Xpa

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Type Details Score
Protein Domain
IPR000465 | XPA
Type: Family
Description: Xeroderma pigmentosum (XP) []is a human autosomal recessive disease,characterised by a high incidence of sunlight-induced skin cancer. Skin cells of individual's with this condition are hypersensitive to ultraviolet light, dueto defects in the incision step of DNA excision repair. There are a minimum ofseven genetic complementation groups involved in this pathway: XP-A to XP-G.XP-A is the most severe form of the disease and is due to defects in a 30kDanuclear protein called XPA (or XPAC) [].The sequence of the XPA protein is conserved from higher eukaryotes []toyeast (gene RAD14) []. XPA is a hydrophilic protein of 247 to 296 amino-acidresidues which has a C4-type zinc finger motif in its central section.
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Gene
7507 | XPA
Type: gene
Organism: human
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Gene
549490 | xpa
Type: gene
Organism: frog, western clawed
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Gene
key_92409 | XPA
Type: gene
Organism: hamster, Chinese
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Gene
298074 | Xpa
Type: gene
Organism: rat
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Gene
481623 | XPA
Type: gene
Organism: dog, domestic
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Gene
747191 | XPA
Type: gene
Organism: chimpanzee
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Gene
537958 | XPA
Type: gene
Organism: cattle
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Gene
395659 | XPA
Type: gene
Organism: chicken
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Gene
393443 | xpa
Type: gene
Organism: zebrafish
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Gene
715705 | XPA
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:99135 | Xpa
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8K2X7
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: false
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Publication
9110400 | J:41543
First Author: de Vries A
Year: 1996
Journal: Semin Cancer Biol
Title: Xpa knockout mice.
Volume: 7
Issue: 5
Pages: 229-40
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Gene
56949 | XAB2
Type: gene
Organism: human
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Publication
1918083 | -
First Author: Miura N
Year: 1991
Journal: J Biol Chem
Title: Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene.
Volume: 266
Issue: 29
Pages: 19786-9
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Publication
1764072 | -
First Author: Shimamoto T
Year: 1991
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis and Drosophila melanogaster.
Volume: 181
Issue: 3
Pages: 1231-7
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Publication
1741034 | -
First Author: Bankmann M
Year: 1992
Journal: Nature
Title: Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins.
Volume: 355
Issue: 6360
Pages: 555-8
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Protein
S4R260
Organism: Mus musculus/domesticus
Length: 134  
Fragment?: true
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Protein
Q64267
Organism: Mus musculus/domesticus
Length: 272  
Fragment?: false
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Protein
Q8R4W5
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Publication
11695547 | J:73024
 
First Author: van Kreijl CF
Year: 2001
Journal: Toxicol Pathol
Title: Xpa and Xpa/p53+/- knockout mice: overview of available data.
Volume: 29 Suppl
Pages: 117-27
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Publication
9044829 | J:38498
First Author: Berg RJ
Year: 1997
Journal: Cancer Res
Title: Relative susceptibilities of XPA knockout mice and their heterozygous and wild-type littermates to UVB-induced skin cancer.
Volume: 57
Issue: 4
Pages: 581-4
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Publication
11888902 | J:75229
First Author: Rebel H
Year: 2002
Journal: Cancer Res
Title: Suppression of UV carcinogenesis by difluoromethylornithine in nucleotide excision repair-deficient Xpa knockout mice.
Volume: 62
Issue: 5
Pages: 1338-42
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Publication
8160271 | -
First Author: Tanaka K
Year: 1994
Journal: Trends Biochem Sci
Title: Xeroderma pigmentosum and nucleotide excision repair of DNA.
Volume: 19
Issue: 2
Pages: 83-6
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Publication
10838141 | J:62684
First Author: van Steeg H
Year: 2000
Journal: Mutat Res
Title: Mutagenesis and carcinogenesis in nucleotide excision repair-deficient XPA knock out mice.
Volume: 450
Issue: 1-2
Pages: 167-80
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Publication
11695546 | J:73025
 
First Author: van Steeg H
Year: 2001
Journal: Toxicol Pathol
Title: DNA repair-deficient Xpa and Xpa/p53+/- knock-out mice: nature of the models.
Volume: 29 Suppl
Pages: 109-16
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GXD Expression
GXD Expression
   
Probe: MGI:5811045
Assay Type: RNA in situ
Annotation Date: 2017-02-09
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1640617
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5823755
Age: embryonic day 10.5
Specimen Label: Supplemental Table 1 - Xpa
Detected: true
Specimen Num: 1
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Publication
24813611 | J:214396
First Author: Fang EF
Year: 2014
Journal: Cell
Title: Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.
Volume: 157
Issue: 4
Pages: 882-896
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Publication
10529736 | J:59517
First Author: van Oostrom CT
Year: 1999
Journal: Environ Mol Mutagen
Title: Effect of heterozygous loss of p53 on benzo[a]pyrene-induced mutations and tumors in DNA repair-deficient XPA mice.
Volume: 34
Issue: 2-3
Pages: 124-30
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Publication
12663525 | J:82831
First Author: Hoogervorst EM
Year: 2003
Journal: Carcinogenesis
Title: Combined oral benzo[a]pyrene and inhalatory ozone exposure have no effect on lung tumor development in DNA repair-deficient Xpa mice.
Volume: 24
Issue: 3
Pages: 613-9
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Publication
12509265 | J:81189
First Author: de Waard H
Year: 2003
Journal: DNA Repair (Amst)
Title: Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice.
Volume: 2
Issue: 1
Pages: 13-25
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Publication
16464479 | J:107705
First Author: Luijten M
Year: 2006
Journal: Mutat Res
Title: Phenacetin acts as a weak genotoxic compound preferentially in the kidney of DNA repair deficient Xpa mice.
Volume: 596
Issue: 1-2
Pages: 143-50
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Publication
15289314 | J:91875
First Author: Hoogervorst EM
Year: 2004
Journal: Cancer Res
Title: p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice.
Volume: 64
Issue: 15
Pages: 5118-26
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Publication
11764287 | J:73192
First Author: Horio T
Year: 2001
Journal: J Investig Dermatol Symp Proc
Title: Photobiologic and photoimmunologic characteristics of XPA gene-deficient mice.
Volume: 6
Issue: 1
Pages: 58-63
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Publication
9042415 | J:38283
First Author: Layher SK
Year: 1997
Journal: Mutat Res
Title: Quantification of XPA gene expression levels in human and mouse cell lines by competitive RT-PCR.
Volume: 383
Issue: 1
Pages: 9-19
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Publication
16510579 | J:106704
First Author: van Schanke A
Year: 2006
Journal: Cancer Res
Title: Induction of nevi and skin tumors in Ink4a/Arf Xpa knockout mice by neonatal, intermittent, or chronic UVB exposures.
Volume: 66
Issue: 5
Pages: 2608-15
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Publication
11142773 | J:67114
First Author: Horiki S
Year: 2000
Journal: Arch Dermatol Res
Title: Protective effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice.
Volume: 292
Issue: 10
Pages: 511-8
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Publication
12531021 | J:79734
First Author: Yoshino M
Year: 2002
Journal: DNA Repair (Amst)
Title: Additive roles of XPA and MSH2 genes in UVB-induced skin tumorigenesis in mice.
Volume: 1
Issue: 11
Pages: 935-40
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Publication
10837020 | J:62877
First Author: Ide F
Year: 2000
Journal: Carcinogenesis
Title: Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors.
Volume: 21
Issue: 6
Pages: 1263-5
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Publication
15191564 | J:90498
First Author: Yamazaki F
Year: 2004
Journal: J Invest Dermatol
Title: XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesis.
Volume: 123
Issue: 1
Pages: 220-8
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Publication
21926083 | J:177762
First Author: Hubert L Jr
Year: 2011
Journal: Hum Mol Genet
Title: Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.
Volume: 20
Issue: 24
Pages: 4822-30
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Publication
15661658 | J:95931
First Author: Shiomi N
Year: 2005
Journal: DNA Repair (Amst)
Title: Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg.
Volume: 4
Issue: 3
Pages: 351-7
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Publication
11906820 | J:84770
First Author: Sim DL
Year: 2002
Journal: Int J Biochem Cell Biol
Title: The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner.
Volume: 34
Issue: 5
Pages: 487-504
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Publication
9180928 | J:41292
First Author: de Vries A
Year: 1997
Journal: Mol Carcinog
Title: Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice.
Volume: 19
Issue: 1
Pages: 46-53
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Publication
7675086 | J:28710
First Author: de Vries A
Year: 1995
Journal: Nature
Title: Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
Volume: 377
Issue: 6545
Pages: 169-73
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Publication
10022133 | J:53216
First Author: Giese H
Year: 1999
Journal: Oncogene
Title: Accelerated accumulation of somatic mutations in mice deficient in the nucleotide excision repair gene XPA.
Volume: 18
Issue: 5
Pages: 1257-60
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Publication
9702178 | J:49319
First Author: De Vries A
Year: 1998
Journal: Exp Eye Res
Title: Ultraviolet-B induced hyperplasia and squamous cell carcinomas in the cornea of XPA-deficient mice.
Volume: 67
Issue: 1
Pages: 53-9
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Publication
9661901 | J:48442
First Author: Bol SA
Year: 1998
Journal: Cancer Res
Title: Elevated frequencies of benzo(a)pyrene-induced Hprt mutations in internal tissue of XPA-deficient mice.
Volume: 58
Issue: 13
Pages: 2850-6
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Publication
11221893 | J:67345
First Author: Rebel H
Year: 2001
Journal: Cancer Res
Title: Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity.
Volume: 61
Issue: 3
Pages: 977-83
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Publication
11323179 | J:69215
First Author: van Steeg H
Year: 2001
Journal: Toxicol Lett
Title: The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis.
Volume: 120
Issue: 1-3
Pages: 209-19
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Publication
35422806 | J:323995
 
First Author: Kajitani GS
Year: 2022
Journal: Front Immunol
Title: Photorepair of Either CPD or 6-4PP DNA Lesions in Basal Keratinocytes Attenuates Ultraviolet-Induced Skin Effects in Nucleotide Excision Repair Deficient Mice.
Volume: 13
Pages: 800606
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Publication
22828138 | J:193152
First Author: John K
Year: 2012
Journal: Carcinogenesis
Title: Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days.
Volume: 33
Issue: 11
Pages: 2236-41
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Publication
9450477 | J:45598
First Author: de Vries A
Year: 1997
Journal: Carcinogenesis
Title: Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
Volume: 18
Issue: 12
Pages: 2327-32
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Publication
9619829 | J:47450
First Author: de Vries A
Year: 1998
Journal: Oncogene
Title: XPA-deficiency in hairless mice causes a shift in skin tumor types and mutational target genes after exposure to low doses of U.V.B.
Volume: 16
Issue: 17
Pages: 2205-12
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Publication
15657287 | J:95557
First Author: Schwarz A
Year: 2005
Journal: J Exp Med
Title: Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair.
Volume: 201
Issue: 2
Pages: 173-9
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Publication
19037232 | J:150979
First Author: Jantschitsch C
Year: 2009
Journal: J Invest Dermatol
Title: Infrared radiation confers resistance to UV-induced apoptosis via reduction of DNA damage and upregulation of antiapoptotic proteins.
Volume: 129
Issue: 5
Pages: 1271-9
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Publication
23395695 | J:199551
First Author: Vaid M
Year: 2013
Journal: Biochem Pharmacol
Title: Silymarin inhibits ultraviolet radiation-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells.
Volume: 85
Issue: 8
Pages: 1066-76
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Publication
16178126 | J:101774
First Author: McAnulty PA
Year: 2005
Journal: Toxicol Pathol
Title: Diethylstilbestrol (DES): carcinogenic potential in Xpa-/-, Xpa-/- / p53+/-, and wild-type mice during 9 months' dietary exposure.
Volume: 33
Issue: 5
Pages: 609-20
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Publication
25368379 | J:224309
First Author: Donninger H
Year: 2015
Journal: Mol Cell Biol
Title: The RASSF1A tumor suppressor regulates XPA-mediated DNA repair.
Volume: 35
Issue: 1
Pages: 277-87
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Publication
16493047 | J:129420
First Author: Schwarz A
Year: 2006
Journal: J Immunol
Title: IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression.
Volume: 176
Issue: 5
Pages: 2896-901
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Publication
19727119 | J:159571
First Author: Majewski S
Year: 2010
Journal: J Invest Dermatol
Title: IL-23 antagonizes UVR-induced immunosuppression through two mechanisms: reduction of UVR-induced DNA damage and inhibition of UVR-induced regulatory T cells.
Volume: 130
Issue: 2
Pages: 554-62
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Publication
19136475 | J:146183
First Author: van Kesteren PC
Year: 2009
Journal: Carcinogenesis
Title: DNA repair-deficient Xpa/p53 knockout mice are sensitive to the non-genotoxic carcinogen cyclosporine A: escape of initiated cells from immunosurveillance?
Volume: 30
Issue: 3
Pages: 538-43
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Publication
14632192 | J:85982
First Author: Kölgen W
Year: 2003
Journal: J Invest Dermatol
Title: Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression.
Volume: 121
Issue: 4
Pages: 751-6
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Publication
15533832 | J:94445
First Author: Hoogervorst EM
Year: 2005
Journal: DNA Repair (Amst)
Title: 2-AAF-induced tumor development in nucleotide excision repair-deficient mice is associated with a defect in global genome repair but not with transcription coupled repair.
Volume: 4
Issue: 1
Pages: 3-9
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Publication
26723900 | J:346513
 
First Author: Kucab JE
Year: 2016
Journal: DNA Repair (Amst)
Title: TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts.
Volume: 39
Pages: 21-33
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Publication
11442761 | J:110895
First Author: Boonstra A
Year: 2001
Journal: J Invest Dermatol
Title: Differential ultraviolet-B-induced immunomodulation in XPA, XPC, and CSB DNA repair-deficient mice.
Volume: 117
Issue: 1
Pages: 141-6
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Publication
19696161 | J:153537
First Author: Jonker MJ
Year: 2009
Journal: Carcinogenesis
Title: Finding transcriptomics biomarkers for in vivo identification of (non-)genotoxic carcinogens using wild-type and Xpa/p53 mutant mouse models.
Volume: 30
Issue: 10
Pages: 1805-12
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Publication
21715664 | J:175079
First Author: van Kesteren PC
Year: 2011
Journal: Toxicol Sci
Title: Deregulation of cancer-related pathways in primary hepatocytes derived from DNA repair-deficient Xpa-/-p53+/- mice upon exposure to benzo[a]pyrene.
Volume: 123
Issue: 1
Pages: 123-32
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Publication
19114557 | J:145759
First Author: Andressoo JO
Year: 2009
Journal: Mol Cell Biol
Title: An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.
Volume: 29
Issue: 5
Pages: 1276-90
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Publication
16472827 | J:107722
First Author: Dollé ME
Year: 2006
Journal: Mutat Res
Title: Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice.
Volume: 596
Issue: 1-2
Pages: 22-35
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Publication
11408355 | J:70351
First Author: Wijnhoven SW
Year: 2001
Journal: Carcinogenesis
Title: DMBA-induced toxic and mutagenic responses vary dramatically between NER-deficient Xpa, Xpc and Csb mice.
Volume: 22
Issue: 7
Pages: 1099-106
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Publication
10843671 | J:112137
First Author: Garssen J
Year: 2000
Journal: J Immunol
Title: Transcription-coupled and global genome repair differentially influence UV-B-induced acute skin effects and systemic immunosuppression.
Volume: 164
Issue: 12
Pages: 6199-205
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Publication
15692571 | J:96496
First Author: Prasher JM
Year: 2005
Journal: EMBO J
Title: Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice.
Volume: 24
Issue: 4
Pages: 861-71
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Publication
15949822 | J:100610
First Author: van Zeeland AA
Year: 2005
Journal: Mutat Res
Title: Transcription-coupled repair: impact on UV-induced mutagenesis in cultured rodent cells and mouse skin tumors.
Volume: 577
Issue: 1-2
Pages: 170-8
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Publication
10416615 | J:56307
First Author: de Boer J
Year: 1999
Journal: Cancer Res
Title: Mouse model for the DNA repair/basal transcription disorder trichothiodystrophy reveals cancer predisposition.
Volume: 59
Issue: 14
Pages: 3489-94
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Publication
15199134 | J:91596
First Author: Niedernhofer LJ
Year: 2004
Journal: Mol Cell Biol
Title: The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.
Volume: 24
Issue: 13
Pages: 5776-87
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Publication
7675085 | J:28709
First Author: Nakane H
Year: 1995
Journal: Nature
Title: High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene.
Volume: 377
Issue: 6545
Pages: 165-8
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Publication
18790090 | J:141237
First Author: Nakane H
Year: 2008
Journal: DNA Repair (Amst)
Title: Impaired spermatogenesis and elevated spontaneous tumorigenesis in xeroderma pigmentosum group A gene (Xpa)-deficient mice.
Volume: 7
Issue: 12
Pages: 1938-50
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Publication
10862569 | J:62970
First Author: Gulezian D
Year: 2000
Journal: Toxicol Pathol
Title: Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment.
Volume: 28
Issue: 3
Pages: 482-99
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Gene
245976 | Xab2
Type: gene
Organism: rat
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Gene
468695 | XAB2
Type: gene
Organism: chimpanzee
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Gene
484995 | XAB2
Type: gene
Organism: dog, domestic
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Gene
528991 | XAB2
Type: gene
Organism: cattle
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Gene
387600 | xab2
Type: gene
Organism: zebrafish
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Gene
704109 | XAB2
Type: gene
Organism: macaque, rhesus
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Gene
100216162 | xab2
Type: gene
Organism: frog, western clawed
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Publication
11285198 | J:68477
First Author: Klein JC
Year: 2001
Journal: Carcinogenesis
Title: Intestinal toxicity and carcinogenic potential of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in DNA repair deficient XPA-/- mice.
Volume: 22
Issue: 4
Pages: 619-26
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Publication
11950998 | J:76608
First Author: de Boer J
Year: 2002
Journal: Science
Title: Premature aging in mice deficient in DNA repair and transcription.
Volume: 296
Issue: 5571
Pages: 1276-9
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Publication
18316597 | J:132760
First Author: Melis JP
Year: 2008
Journal: Cancer Res
Title: Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes.
Volume: 68
Issue: 5
Pages: 1347-53
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Publication
15955109 | J:100148
First Author: Miyauchi-Hashimoto H
Year: 2005
Journal: J Invest Dermatol
Title: Ultraviolet radiation-induced impairment of tumor rejection is enhanced in xeroderma pigmentosum a gene-deficient mice.
Volume: 124
Issue: 6
Pages: 1313-7
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Publication
11376684 | J:97333
First Author: Tanaka K
Year: 2001
Journal: Mutat Res
Title: UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency.
Volume: 477
Issue: 1-2
Pages: 31-40
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Publication
11313422 | J:69052
First Author: Miyauchi-Hashimoto H
Year: 2001
Journal: J Immunol
Title: Carcinogen-induced inflammation and immunosuppression are enhanced in xeroderma pigmentosum group A model mice associated with hyperproduction of prostaglandin E2.
Volume: 166
Issue: 9
Pages: 5782-91
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