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Search results 1 to 92 out of 92 for Xrcc2

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
7516 | XRCC2
Type: gene
Organism: human
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Gene
100486989 | xrcc2
Type: gene
Organism: frog, western clawed
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Protein Domain
IPR030547 | XRCC2
Type: Family
Description: DNA repair protein XRCC2 is a RAD51 paralogue. In humans, it is part of the protein complex BCDX2 (contains RAD51B, RAD51C, RAD51D, and XRCC2), which acts in the BRCA1-BRCA2-dependent homologous recombination pathway [, ]. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA []. Interestingly, XRCC2 and other homologous recombination proteins are associated with centrosomes and are required for mitotic stability [].
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Gene
499966 | Xrcc2
Type: gene
Organism: rat
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Gene
475548 | XRCC2
Type: gene
Organism: dog, domestic
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Gene
738997 | XRCC2
Type: gene
Organism: chimpanzee
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Gene
789410 | XRCC2
Type: gene
Organism: cattle
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Gene
420438 | XRCC2
Type: gene
Organism: chicken
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Gene
553395 | xrcc2
Type: gene
Organism: zebrafish
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Gene
717006 | XRCC2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1927345 | Xrcc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21276791 | J:170858
First Author: Cappelli E
Year: 2011
Journal: Exp Cell Res
Title: Homologous recombination proteins are associated with centrosomes and are required for mitotic stability.
Volume: 317
Issue: 8
Pages: 1203-13
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Publication
30042186 | J:280228
First Author: Yang Y
Year: 2018
Journal: J Med Genet
Title: XRCC2 mutation causes meiotic arrest, azoospermia and infertility.
Volume: 55
Issue: 9
Pages: 628-636
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Protein
Q9CX47
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
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Publication
9628903 | J:48438
First Author: Cartwright R
Year: 1998
Journal: Nucleic Acids Res
Title: The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family.
Volume: 26
Issue: 13
Pages: 3084-9
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Publication
11751635 | -
First Author: Masson JY
Year: 2001
Journal: Genes Dev
Title: Identification and purification of two distinct complexes containing the five RAD51 paralogs.
Volume: 15
Issue: 24
Pages: 3296-307
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Publication
23149936 | -
First Author: Chun J
Year: 2013
Journal: Mol Cell Biol
Title: Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.
Volume: 33
Issue: 2
Pages: 387-95
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Publication
20671066 | J:205233
First Author: Haines JW
Year: 2010
Journal: Mol Cancer Res
Title: Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice.
Volume: 8
Issue: 9
Pages: 1227-33
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Publication
11118202 | J:66529
First Author: Deans B
Year: 2000
Journal: EMBO J
Title: Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice.
Volume: 19
Issue: 24
Pages: 6675-85
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Publication
17116431 | J:120961
First Author: Adam J
Year: 2007
Journal: DNA Repair (Amst)
Title: A role for Xrcc2 in the early stages of mouse development.
Volume: 6
Issue: 2
Pages: 224-34
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Publication
14678973 | J:87096
First Author: Deans B
Year: 2003
Journal: Cancer Res
Title: Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice.
Volume: 63
Issue: 23
Pages: 8181-7
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Publication
20657597 | J:163929
First Author: Hasham MG
Year: 2010
Journal: Nat Immunol
Title: Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination.
Volume: 11
Issue: 9
Pages: 820-6
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Publication
18212067 | J:134209
First Author: Caddle LB
Year: 2008
Journal: Mol Cell Biol
Title: Homologous recombination is necessary for normal lymphocyte development.
Volume: 28
Issue: 7
Pages: 2295-303
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Publication
15979950 | J:105008
First Author: Griffin C
Year: 2005
Journal: DNA Repair (Amst)
Title: The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells.
Volume: 4
Issue: 9
Pages: 1019-27
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Publication
19327148 | J:157288
 
First Author: Gruver AM
Year: 2009
Journal: BMC Mol Biol
Title: Functional characterization and identification of mouse Rad51d splice variants.
Volume: 10
Pages: 27
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Protein Coding Gene
MGP_CAROLIEiJ_G0027031 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029363 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029329 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029280 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029340 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029060 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927345 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029027 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029178 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029262 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029165 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029827 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028196 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028552 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0021804 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028027 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:2662684
Assay Type: RT-PCR
Annotation Date: 2003-06-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2662685
Age: embryonic day 15.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:2662684
Assay Type: RT-PCR
Annotation Date: 2003-06-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2662685
Age: embryonic day 15.5
Specimen Label: +/-
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:2662684
Assay Type: RT-PCR
Annotation Date: 2003-06-13
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603923
Stage: TS23
Assay Id: MGI:2662685
Age: embryonic day 15.5
Specimen Label: -/-
Detected: false
Specimen Num: 3
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Publication
23352430 | J:193481
First Author: Barlow JH
Year: 2013
Journal: Cell
Title: Identification of early replicating fragile sites that contribute to genome instability.
Volume: 152
Issue: 3
Pages: 620-32
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Publication
20813759 | J:173816
First Author: Rajesh C
Year: 2011
Journal: Nucleic Acids Res
Title: The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion.
Volume: 39
Issue: 1
Pages: 132-45
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Publication
19615340 | J:152540
First Author: Kondo N
Year: 2009
Journal: Biochem Biophys Res Commun
Title: DNA ligase IV as a new molecular target for temozolomide.
Volume: 387
Issue: 4
Pages: 656-60
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Publication
19164512 | J:144617
First Author: Frappart PO
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency.
Volume: 106
Issue: 6
Pages: 1880-5
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Publication
16777961 | J:111068
First Author: Orii KE
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development.
Volume: 103
Issue: 26
Pages: 10017-22
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Publication
24899707 | J:211631
First Author: Lee Y
Year: 2014
Journal: J Neurosci
Title: Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.
Volume: 34
Issue: 23
Pages: 7836-44
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Publication
15741177 | J:126097
First Author: Cobellis G
Year: 2005
Journal: Nucleic Acids Res
Title: Tagging genes with cassette-exchange sites.
Volume: 33
Issue: 4
Pages: e44
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: DNA repair protein XRCC2
Type: chain
End: 278
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Publication
10422536 | J:159275
First Author: Cui X
Year: 1999
Journal: Mutat Res
Title: The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells.
Volume: 434
Issue: 2
Pages: 75-88
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Protein
A0A0G2JF58
Organism: Mus musculus/domesticus
Length: 41  
Fragment?: false
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DO Term
DOID:0111085 | Fanconi anemia complementation group U
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DO Term
DOID:0112272 | spermatogenic failure 50
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DO Term
DOID:0080874 | primary ovarian insufficiency 17
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Publication
12000837 | J:76620
First Author: Godthelp BC
Year: 2002
Journal: Nucleic Acids Res
Title: Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability.
Volume: 30
Issue: 10
Pages: 2172-82
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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