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Search results 1 to 100 out of 244 for Xrcc4

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Hits by Pathway

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Hits by Strain

Type Details Score
Gene
7518 | XRCC4
Type: gene
Organism: human
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Gene
100127743 | xrcc4
Type: gene
Organism: frog, western clawed
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Gene
key_80434 | XRCC4
Type: gene
Organism: hamster, Chinese
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Gene
309995 | Xrcc4
Type: gene
Organism: rat
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Gene
488923 | XRCC4
Type: gene
Organism: dog, domestic
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Gene
471491 | XRCC4
Type: gene
Organism: chimpanzee
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Gene
613590 | XRCC4
Type: gene
Organism: cattle
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Gene
427325 | XRCC4
Type: gene
Organism: chicken
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Gene
393759 | xrcc4
Type: gene
Organism: zebrafish
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Gene
712291 | XRCC4
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:1333799 | Xrcc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
- | J:76693
   
First Author: Mori M
Year: 2001
Journal: GenBank Submission
Title: Mus musculus XRCC4 mRNA, complete cds
Pages: AB055154
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Publication
10786799 | J:61973
First Author: Gao Y
Year: 2000
Journal: Nature
Title: Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development.
Volume: 404
Issue: 6780
Pages: 897-900
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Publication
17606631 | J:125880
First Author: Soulas-Sprauel P
Year: 2007
Journal: J Exp Med
Title: Role for DNA repair factor XRCC4 in immunoglobulin class switch recombination.
Volume: 204
Issue: 7
Pages: 1717-27
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Publication
16670198 | J:109585
First Author: Yan CT
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice.
Volume: 103
Issue: 19
Pages: 7378-83
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Publication
8548796 | J:30403
First Author: Li Z
Year: 1995
Journal: Cell
Title: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination.
Volume: 83
Issue: 7
Pages: 1079-89
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Publication
34519267 | J:316933
   
First Author: Roch B
Year: 2021
Journal: Elife
Title: An XRCC4 mutant mouse, a model for human X4 syndrome, reveals interplays with Xlf, PAXX, and ATM in lymphoid development.
Volume: 10
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Publication
9875844 | J:65218
First Author: Gao Y
Year: 1998
Journal: Cell
Title: A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis.
Volume: 95
Issue: 7
Pages: 891-902
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Publication
18332040 | J:173075
First Author: Schulte-Uentrop L
Year: 2008
Journal: Nucleic Acids Res
Title: Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks.
Volume: 36
Issue: 8
Pages: 2561-9
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Publication
18093953 | J:141638
First Author: Guirouilh-Barbat J
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends.
Volume: 104
Issue: 52
Pages: 20902-7
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Publication
26740101 | J:316141
 
First Author: Chen Z
Year: 2016
Journal: J Hematol Oncol
Title: Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity.
Volume: 9
Pages: 2
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Publication
33725486 | J:305632
First Author: Maruoka M
Year: 2021
Journal: Mol Cell
Title: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
Volume: 81
Issue: 7
Pages: 1397-1410.e9
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Publication
23028374 | J:190448
First Author: Arlt MF
Year: 2012
Journal: PLoS Genet
Title: De novo CNV formation in mouse embryonic stem cells occurs in the absence of Xrcc4-dependent nonhomologous end joining.
Volume: 8
Issue: 9
Pages: e1002981
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Publication
11516951 | J:115412
First Author: d'Adda di Fagagna F
Year: 2001
Journal: Curr Biol
Title: Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells.
Volume: 11
Issue: 15
Pages: 1192-6
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Publication
8090368 | J:19354
First Author: Yamano M
Year: 1994
Journal: Neurosci Res
Title: Distribution of corticotropin-releasing factor and calcitonin gene-related peptide in the developing mouse cerebellum.
Volume: 19
Issue: 4
Pages: 387-96
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Publication
10716994 | J:110848
First Author: Gu Y
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.
Volume: 97
Issue: 6
Pages: 2668-73
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Protein
E0CZC8
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
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Protein
E0CY05
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
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Publication
12517771 | -
First Author: Lee JW
Year: 2003
Journal: Cancer Res
Title: Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro.
Volume: 63
Issue: 1
Pages: 22-4
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Publication
28759779 | J:277029
 
First Author: Xing M
Year: 2017
Journal: DNA Repair (Amst)
Title: Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.
Volume: 57
Pages: 133-138
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Publication
17713479 | J:126758
First Author: Yan CT
Year: 2007
Journal: Nature
Title: IgH class switching and translocations use a robust non-classical end-joining pathway.
Volume: 449
Issue: 7161
Pages: 478-82
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Publication
19103754 | J:145721
First Author: Malivert L
Year: 2009
Journal: Mol Cell Biol
Title: The C-terminal domain of Cernunnos/XLF is dispensable for DNA repair in vivo.
Volume: 29
Issue: 5
Pages: 1116-22
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Publication
34521752 | J:310613
 
First Author: Wang XS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Volume: 118
Issue: 38
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Publication
20133615 | J:157574
First Author: Rucci F
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome.
Volume: 107
Issue: 7
Pages: 3024-9
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Publication
26774286 | J:232858
First Author: Zhang Q
Year: 2016
Journal: Mol Cell
Title: FBXW7 Facilitates Nonhomologous End-Joining via K63-Linked Polyubiquitylation of XRCC4.
Volume: 61
Issue: 3
Pages: 419-433
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Protein
Q924T3
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
A0A0R4J1Y0
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
A0A0R4J024
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Publication
29077092 | J:274050
First Author: Abramowski V
Year: 2018
Journal: Cell Death Differ
Title: PAXX and Xlf interplay revealed by impaired CNS development and immunodeficiency of double KO mice.
Volume: 25
Issue: 2
Pages: 444-452
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Publication
28094268 | J:248007
 
First Author: Kang YJ
Year: 2017
Journal: Nat Commun
Title: Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.
Volume: 8
Pages: 14013
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Publication
30072430 | J:264598
First Author: Crowe JL
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.
Volume: 115
Issue: 34
Pages: 8615-8620
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Publication
17360556 | J:120145
First Author: Zha S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.
Volume: 104
Issue: 11
Pages: 4518-23
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Publication
12110179 | J:77972
First Author: Zhu C
Year: 2002
Journal: Cell
Title: Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations.
Volume: 109
Issue: 7
Pages: 811-21
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Publication
9889105 | J:51608
First Author: Barnes DE
Year: 1998
Journal: Curr Biol
Title: Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.
Volume: 8
Issue: 25
Pages: 1395-8
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Publication
9823897 | J:50865
First Author: Frank KM
Year: 1998
Journal: Nature
Title: Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV.
Volume: 396
Issue: 6707
Pages: 173-7
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Publication
16757976 | J:109354
First Author: Chao C
Year: 2006
Journal: EMBO J
Title: Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.
Volume: 25
Issue: 11
Pages: 2615-22
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Publication
17172844 | J:191183
First Author: Feng L
Year: 2006
Journal: Cell Cycle
Title: Ser46 phosphorylation regulates p53-dependent apoptosis and replicative senescence.
Volume: 5
Issue: 23
Pages: 2812-9
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Publication
20142431 | J:158825
First Author: Boboila C
Year: 2010
Journal: J Exp Med
Title: Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4.
Volume: 207
Issue: 2
Pages: 417-27
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Publication
21242524 | J:169152
First Author: Eccleston J
Year: 2011
Journal: J Immunol
Title: Mismatch repair proteins MSH2, MLH1, and EXO1 are important for class-switch recombination events occurring in B cells that lack nonhomologous end joining.
Volume: 186
Issue: 4
Pages: 2336-43
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Publication
11751629 | J:73443
First Author: Pierce AJ
Year: 2001
Journal: Genes Dev
Title: Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells.
Volume: 15
Issue: 24
Pages: 3237-42
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Publication
37307443 | J:360028
First Author: Zhu Y
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient and productive lymphocyte development in XLF-deficient mice.
Volume: 120
Issue: 25
Pages: e2221894120
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Publication
24913804 | J:215685
First Author: Lamparter C
Year: 2014
Journal: Toxicol Sci
Title: Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos.
Volume: 141
Issue: 1
Pages: 59-67
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Publication
12846809 | J:85021
 
First Author: Mills KD
Year: 2003
Journal: Immunol Rev
Title: The role of DNA breaks in genomic instability and tumorigenesis.
Volume: 194
Pages: 77-95
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Publication
28057860 | J:240170
First Author: Bhargava R
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Contribution of canonical nonhomologous end joining to chromosomal rearrangements is enhanced by ATM kinase deficiency.
Volume: 114
Issue: 4
Pages: 728-733
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Publication
19587764 | J:150339
First Author: Wang JH
Year: 2009
Journal: Nature
Title: Mechanisms promoting translocations in editing and switching peripheral B cells.
Volume: 460
Issue: 7252
Pages: 231-6
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Publication
25818648 | J:220823
First Author: Jiang W
Year: 2015
Journal: Mol Cell
Title: Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining.
Volume: 58
Issue: 1
Pages: 172-85
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Protein Coding Gene
MGP_CAROLIEiJ_G0018756 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0020801 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0020755 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0020728 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0020751 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0020545 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1333799 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021188 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020063 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0020504 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0020629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0020609 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0020702 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0020638 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021228 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0019816 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020121 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0015835 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0019639 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185813
Stage: TS13
Assay Id: MGI:5616608
Age: embryonic day 8.5
Specimen Label: Head
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610513
Stage: TS13
Assay Id: MGI:5616608
Age: embryonic day 8.5
Specimen Label: Heart
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185713
Stage: TS13
Assay Id: MGI:5616608
Age: embryonic day 8.5
Specimen Label: Trunk
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185815
Stage: TS15
Assay Id: MGI:5616615
Age: embryonic day 9.5
Specimen Label: Head
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:5616615
Age: embryonic day 9.5
Specimen Label: Heart
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5616600
Assay Type: RT-PCR
Annotation Date: 2015-02-24
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3185715
Stage: TS15
Assay Id: MGI:5616615
Age: embryonic day 9.5
Specimen Label: Trunk
Detected: true
Specimen Num: 3
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Publication
16354685 | J:104162
First Author: Weinstock DM
Year: 2006
Journal: Mol Cell Biol
Title: Alternative pathways for the repair of RAG-induced DNA breaks.
Volume: 26
Issue: 1
Pages: 131-9
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Publication
32989150 | J:296722
First Author: Wang XS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: CtIP-mediated DNA resection is dispensable for IgH class switch recombination by alternative end-joining.
Volume: 117
Issue: 41
Pages: 25700-25711
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Publication
27769169 | J:239329
First Author: Chen Z
Year: 2016
Journal: BMC Genomics
Title: Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing.
Volume: 17
Issue: 1
Pages: 823
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Publication
15194694 | J:92391
First Author: Wang YG
Year: 2004
Journal: J Biol Chem
Title: Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
Volume: 279
Issue: 36
Pages: 37282-90
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Publication
35764636 | J:332737
First Author: Vincendeau E
Year: 2022
Journal: Nat Commun
Title: SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.
Volume: 13
Issue: 1
Pages: 3707
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Publication
22308491 | J:182020
First Author: Boboila C
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).
Volume: 109
Issue: 7
Pages: 2473-8
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Publication
20133803 | J:157537
First Author: Boboila C
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70.
Volume: 107
Issue: 7
Pages: 3034-9
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Publication
20010689 | J:155801
First Author: Gostissa M
Year: 2009
Journal: Nature
Title: Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.
Volume: 462
Issue: 7274
Pages: 803-7
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Publication
23345432 | J:194333
First Author: Oksenych V
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
Volume: 110
Issue: 6
Pages: 2234-9
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Publication
14690602 | J:125414
First Author: Zhu XD
Year: 2003
Journal: Mol Cell
Title: ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes.
Volume: 12
Issue: 6
Pages: 1489-98
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Publication
21459848 | J:182963
First Author: Laulier C
Year: 2011
Journal: Nucleic Acids Res
Title: The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.
Volume: 39
Issue: 14
Pages: 5935-44
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Publication
19076778 | J:173443
First Author: Huse JT
Year: 2009
Journal: Brain Pathol
Title: Genetically engineered mouse models of brain cancer and the promise of preclinical testing.
Volume: 19
Issue: 1
Pages: 132-43
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Publication
28671691 | J:249066
First Author: Gompers AL
Year: 2017
Journal: Nat Neurosci
Title: Germline Chd8 haploinsufficiency alters brain development in mouse.
Volume: 20
Issue: 8
Pages: 1062-1073
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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