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Search results 1 to 93 out of 93 for Xrn2

0.043s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
22803 | XRN2
Type: gene
Organism: human
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Gene
733834 | xrn2
Type: gene
Organism: frog, western clawed
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Gene
362229 | Xrn2
Type: gene
Organism: rat
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Gene
458131 | XRN2
Type: gene
Organism: chimpanzee
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Gene
477133 | XRN2
Type: gene
Organism: dog, domestic
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Gene
517417 | XRN2
Type: gene
Organism: cattle
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Gene
421236 | XRN2
Type: gene
Organism: chicken
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Gene
321940 | xrn2
Type: gene
Organism: zebrafish
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Gene
700934 | XRN2
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:894687 | Xrn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
19915612 | J:160408
First Author: Lu Y
Year: 2010
Journal: Oncogene
Title: Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor.
Volume: 29
Issue: 7
Pages: 1041-9
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Publication
21036871 | J:173805
First Author: Wang M
Year: 2011
Journal: Nucleic Acids Res
Title: 5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay.
Volume: 39
Issue: 5
Pages: 1811-22
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Publication
27331609 | J:269711
   
First Author: Nimura K
Year: 2016
Journal: Elife
Title: Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development.
Volume: 5
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Publication
37697435 | J:342028
First Author: Krishnan R
Year: 2023
Journal: Nucleic Acids Res
Title: RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells.
Volume: 51
Issue: 19
Pages: 10484-10505
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Protein Coding Gene
MGP_CAROLIEiJ_G0024400 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026601 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026565 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026539 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026577 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026320 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_894687 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027022 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0025781 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026434 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026398 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026538 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026418 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027077 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025517 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0025855 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0025843 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025318 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
7885830 | J:23616
First Author: Shobuike T
Year: 1995
Journal: Nucleic Acids Res
Title: Characterization of cDNA encoding mouse homolog of fission yeast dhp1+ gene: structural and functional conservation.
Volume: 23
Issue: 3
Pages: 357-61
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Publication
22767893 | J:185950
First Author: Padmanabhan K
Year: 2012
Journal: Science
Title: Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.
Volume: 337
Issue: 6094
Pages: 599-602
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Publication
22057269 | J:180676
First Author: Noren Hooten N
Year: 2011
Journal: J Biol Chem
Title: Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).
Volume: 286
Issue: 52
Pages: 44679-90
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Publication
16919269 | J:112701
First Author: Bailey PJ
Year: 2006
Journal: Exp Cell Res
Title: A global genomic transcriptional code associated with CNS-expressed genes.
Volume: 312
Issue: 16
Pages: 3108-19
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10409438 | J:56711
First Author: Zhang M
Year: 1999
Journal: Genomics
Title: Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2.
Volume: 59
Issue: 2
Pages: 252-4
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Publication
26779609 | -
First Author: Richter H
Year: 2016
Journal: Nat Struct Mol Biol
Title: Structural basis and function of XRN2 binding by XTB domains.
Volume: 23
Issue: 2
Pages: 164-71
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Publication
24462208 | -
First Author: Miki TS
Year: 2014
Journal: Mol Cell
Title: PAXT-1 promotes XRN2 activity by stabilizing it through a conserved domain.
Volume: 53
Issue: 2
Pages: 351-60
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GO Term
GO:0180037 | rapid tRNA decay
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Protein Domain
IPR041412 | Xrn1_helical
Type: Domain
Description: This helical domain is part of the Xrn1 catalytic core []. Xrn1 is a cytoplasmic 5'-3' exonuclease that degrades decapped mRNAs. This domain can also be found in Xrn2 [].
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Protein
Q9D211
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
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Protein
F6XNW8
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: true
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Protein
A0A1I7Q4A1
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
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Publication
15109303 | -
First Author: Hasan MK
Year: 2004
Journal: Biochem J
Title: Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control.
Volume: 380
Issue: Pt 3
Pages: 605-10
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Publication
24825908 | -
First Author: Cheung CT
Year: 2014
Journal: J Biol Chem
Title: Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Volume: 289
Issue: 26
Pages: 18258-69
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Protein Domain
IPR021859 | XTBD
Type: Domain
Description: XRN2 is an essential eukaryotic exoribonuclease that processes and degrades various substrates. The ~80-residue XRN2-binding domain (XTBD) constitutes an XRN2-binding module that is employed by different metazoan proteins to link to XRN2 [, ], such as:Caenorhabditis elegans Partner of Xrn-Two protein 1, or PAXT-1 for short. Plays a role in maintenance of steady-state concentration and turnover ofmicroRNAs (miRNA) by degradation of mature miRNA in complex with theexoribonuclease XRN-2 [].Mammalian CDKN2A-interacting protein (CDKN2AIP) or Collaborator of ARF(CARF) that regulates DNA damage response in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis [, ]. Mammalian CDKN2AIP N-terminal-like protein (CDKN2AIPNL).The XTBD domain folds into a globular four-helix bundle (H1-H4) connected by three loops (L1-L3). H1-H3 form an antiparallel helical array and H4 folds back on top of H2 and H3 at a 90degree angle. The four-helical bundle is mainly stabilized by hydrophobic helix-helix interactions together with additional polar interactions between side chains located on neighbouring helices. The four-helix bundle of XTBD represents a structurally unique arrangement for XRN2 binding [].
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Protein
Q8BI72
Organism: Mus musculus/domesticus
Length: 563  
Fragment?: false
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Publication
21362555 | -
First Author: Jinek M
Year: 2011
Journal: Mol Cell
Title: Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.
Volume: 41
Issue: 5
Pages: 600-8
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Publication
18955505 | J:156043
First Author: Yang XC
Year: 2009
Journal: Mol Cell Biol
Title: Studies of the 5' exonuclease and endonuclease activities of CPSF-73 in histone pre-mRNA processing.
Volume: 29
Issue: 1
Pages: 31-42
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Protein
Q9DBR1
Organism: Mus musculus/domesticus
Length: 951  
Fragment?: false
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Publication
20188675 | -
First Author: Jimeno-González S
Year: 2010
Journal: Mol Cell
Title: The yeast 5'-3' exonuclease Rat1p functions during transcription elongation by RNA polymerase II.
Volume: 37
Issue: 4
Pages: 580-7
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Protein
A0A668KL68
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
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Protein
P97789
Organism: Mus musculus/domesticus
Length: 1719  
Fragment?: false
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Protein
A0A087WQN7
Organism: Mus musculus/domesticus
Length: 1719  
Fragment?: false
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Protein
A0A087WNV6
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
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Protein
F8VQ87
Organism: Mus musculus/domesticus
Length: 1723  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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