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Search results 1 to 100 out of 106 for Ythdc1

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Hits by Category

Hits by Strain

Type Details Score
Gene
91746 | YTHDC1
Type: gene
Organism: human
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Gene
493483 | ythdc1
Type: gene
Organism: frog, western clawed
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Gene
170956 | Ythdc1
Type: gene
Organism: rat
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Gene
461291 | YTHDC1
Type: gene
Organism: chimpanzee
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Gene
475161 | YTHDC1
Type: gene
Organism: dog, domestic
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Gene
613858 | YTHDC1
Type: gene
Organism: cattle
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Gene
422656 | YTHDC1
Type: gene
Organism: chicken
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Gene
492769 | ythdc1
Type: gene
Organism: zebrafish
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Gene
709717 | YTHDC1
Type: gene
Organism: macaque, rhesus
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Protein Coding Gene
MGI:2443713 | Ythdc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33658714 | J:309584
First Author: Liu J
Year: 2021
Journal: Nature
Title: The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity.
Volume: 591
Issue: 7849
Pages: 322-326
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Publication
34255814 | J:322771
First Author: Sheng Y
Year: 2021
Journal: Blood
Title: A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Volume: 138
Issue: 26
Pages: 2838-2852
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Publication
36302453 | J:331492
 
First Author: Li X
Year: 2023
Journal: Metabolism
Title: Downregulation of the m(6)A reader protein YTHDC1 leads to islet β-cell failure and diabetes.
Volume: 138
Pages: 155339
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Publication
36878322 | J:339422
 
First Author: Yang K
Year: 2023
Journal: Diabetes Res Clin Pract
Title: Reduction of mRNA m(6)A associates with glucose metabolism via YTHDC1 in human and mice.
Volume: 198
Pages: 110607
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Publication
33886094 | J:309490
First Author: Chen C
Year: 2021
Journal: Protein Cell
Title: Nuclear m6A reader YTHDC1 regulates the scaffold function of LINE1 RNA in mouse ESCs and early embryos.
Volume: 12
Issue: 6
Pages: 455-474
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Publication
34657574 | J:326443
First Author: Liang D
Year: 2022
Journal: Autophagy
Title: m6A reader YTHDC1 modulates autophagy by targeting SQSTM1 in diabetic skin.
Volume: 18
Issue: 6
Pages: 1318-1337
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Publication
36892464 | J:350029
   
First Author: Qiao Y
Year: 2023
Journal: Elife
Title: Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export.
Volume: 12
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Publication
29799838 | J:262823
First Author: Kasowitz SD
Year: 2018
Journal: PLoS Genet
Title: Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.
Volume: 14
Issue: 5
Pages: e1007412
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Publication
29262316 | J:255330
First Author: Shima H
Year: 2017
Journal: Cell Rep
Title: S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1.
Volume: 21
Issue: 12
Pages: 3354-3363
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Publication
39367406 | J:355331
First Author: Mao Y
Year: 2024
Journal: J Neuroinflammation
Title: Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance.
Volume: 21
Issue: 1
Pages: 249
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Protein Coding Gene
MGP_CAROLIEiJ_G0027347 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029674 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029642 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029590 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029651 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0029374 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2443713 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0030105 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028782 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0029343 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0029488 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0029449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029575 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0029477 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0030138 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0028506 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028863 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0017126 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0028339 | -
Type: protein_coding_gene
Organism: Mus spretus
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434146
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434147
Age: embryonic day 18.0
Image: 1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:7434186
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287426
Stage: TS26
Assay Id: MGI:7434196
Age: embryonic day 18.0
Image: 5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7434257
Age: embryonic day 18.0
Image: S5
Specimen Label: CONV
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7433109
Assay Type: RT-PCR
Annotation Date: 2023-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684626
Stage: TS26
Assay Id: MGI:7434284
Age: embryonic day 18.0
Image: S1
Specimen Label: SPF
Detected: true
Specimen Num: 1
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Publication
35874829 | J:327184
 
First Author: Xiao Z
Year: 2022
Journal: Front Cell Dev Biol
Title: The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.
Volume: 10
Pages: 882994
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Publication
37269288 | J:337931
First Author: Li L
Year: 2023
Journal: Cell Rep
Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
Volume: 42
Issue: 6
Pages: 112596
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
GSE209840 | The effects of YTHDC1 on islet beta-cell function
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
F6Y6H7
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: true
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Protein
A2AWN7
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
E9PW90
Organism: Mus musculus/domesticus
Length: 51  
Fragment?: false
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Protein Domain
IPR007275 | YTH_domain
Type: Domain
Description: The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain []. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1. In Saccharomyces cerevisiae, Pho92 is a post-transcriptional regulator that regulates Pho4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. Its YTH domain exhibits RNA-binding activity []. In Schizosaccharomyces pombe, Mmi1 has been identified as eliminating meiosis-specific mRNAs []. Rat YTHDC1 (also known as YT521-B) is an alternative splicing regulator that recognises and binds N6-methyladenosine (m6A)-containing RNAs. The YTH domain of YT521-B is a RNA-binding domain with a very degenerate sequence-specificity [].
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Protein Domain
IPR045168 | YTH_prot
Type: Family
Description: The YTH (YT521-B homology) domain has been suggested to be an evolutionarily conserved m6A-dependent RNA binding domain []. Proteins containing this domain includes mammalian YTHD and YTDC proteins, Arabidopsis CPSF30 (At1g30460), budding yeast Pho92 and fission yeast Mmi1. In Saccharomyces cerevisiae, Pho92 is a post-transcriptional regulator that regulates Pho4 mRNA stability by binding to the 3'-UTR in a phosphate-dependent manner. Its YTH domain exhibits RNA-binding activity []. In Schizosaccharomyces pombe, Mmi1 has been identified as eliminating meiosis-specific mRNAs []. Rat YTHDC1 (also known as YT521-B) is an alternative splicing regulator that recognises and binds N6-methyladenosine (m6A)-containing RNAs. The YTH domain of YT521-B is a RNA-binding domain with a very degenerate sequence-specificity [].
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Protein
Q8BYK6
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: false
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Protein
Q91YT7
Organism: Mus musculus/domesticus
Length: 579  
Fragment?: false
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Protein
P59326
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
E9Q5K9
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
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Protein
Q3U8D6
Organism: Mus musculus/domesticus
Length: 89  
Fragment?: true
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Protein
A2AWN8
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Protein
D6RG95
Organism: Mus musculus/domesticus
Length: 545  
Fragment?: false
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Protein
Q7TN20
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
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Protein
Q3UNH5
Organism: Mus musculus/domesticus
Length: 584  
Fragment?: false
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Protein
Q8R5D2
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
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Protein
Q8BVC6
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
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Protein
Q3TH60
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein
Q3UST9
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: true
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Publication
16823445 | -
First Author: Harigaya Y
Year: 2006
Journal: Nature
Title: Selective elimination of messenger RNA prevents an incidence of untimely meiosis.
Volume: 442
Issue: 7098
Pages: 45-50
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Publication
24206186 | -
First Author: Kang HJ
Year: 2014
Journal: Biochem J
Title: A novel protein, Pho92, has a conserved YTH domain and regulates phosphate metabolism by decreasing the mRNA stability of PHO4 in Saccharomyces cerevisiae.
Volume: 457
Issue: 3
Pages: 391-400
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Publication
26318451 | -
First Author: Xu C
Year: 2015
Journal: J Biol Chem
Title: Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins.
Volume: 290
Issue: 41
Pages: 24902-13
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom