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Search results 1 to 100 out of 307 for Zap70

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Type Details Score
Gene
7535 | ZAP70
Type: gene
Organism: human
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Gene
100271860 | ZAP70
Type: gene
Organism: dog, domestic
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Gene
504509 | ZAP70
Type: gene
Organism: cattle
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Gene
420086 | ZAP70
Type: gene
Organism: chicken
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Gene
553615 | zap70
Type: gene
Organism: zebrafish
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Gene
707555 | ZAP70
Type: gene
Organism: macaque, rhesus
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Gene
448557 | zap70
Type: gene
Organism: frog, western clawed
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Gene
301348 | Zap70
Type: gene
Organism: rat
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Gene
459427 | ZAP70
Type: gene
Organism: chimpanzee
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Protein Coding Gene
MGI:99613 | Zap70
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
29915297 | J:282544
First Author: Lo WL
Year: 2018
Journal: Nat Immunol
Title: Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT.
Volume: 19
Issue: 7
Pages: 733-741
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Publication
18465772 | J:136323
First Author: Fallah-Arani F
Year: 2008
Journal: Eur J Immunol
Title: Redundant role for Zap70 in B cell development and activation.
Volume: 38
Issue: 6
Pages: 1721-33
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Publication
24164480 | J:211510
First Author: Cauwe B
Year: 2014
Journal: Immunology
Title: A novel Zap70 mutation with reduced protein stability demonstrates the rate-limiting threshold for Zap70 in T-cell receptor signalling.
Volume: 141
Issue: 3
Pages: 377-87
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Publication
30992398 | J:284348
 
First Author: Xie J
Year: 2019
Journal: Sci Signal
Title: Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling.
Volume: 12
Issue: 577
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Publication
28159798 | J:241231
First Author: Hsu LY
Year: 2017
Journal: J Exp Med
Title: Destabilizing the autoinhibitory conformation of Zap70 induces up-regulation of inhibitory receptors and T cell unresponsiveness.
Volume: 214
Issue: 3
Pages: 833-849
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Publication
24596147 | J:211203
 
First Author: Jenkins MR
Year: 2014
Journal: Elife
Title: Distinct structural and catalytic roles for Zap70 in formation of the immunological synapse in CTL.
Volume: 3
Pages: e01310
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Publication
27869819 | J:259574
First Author: Katz ZB
Year: 2017
Journal: Nat Immunol
Title: A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
Volume: 18
Issue: 1
Pages: 86-95
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Publication
23267019 | J:192604
First Author: Borroto A
Year: 2013
Journal: J Immunol
Title: Nck recruitment to the TCR required for ZAP70 activation during thymic development.
Volume: 190
Issue: 3
Pages: 1103-12
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Publication
26390156 | J:233782
First Author: Yang M
Year: 2015
Journal: Nat Immunol
Title: K33-linked polyubiquitination of Zap70 by Nrdp1 controls CD8(+) T cell activation.
Volume: 16
Issue: 12
Pages: 1253-62
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Publication
17028588 | J:113565
First Author: Gu Y
Year: 2006
Journal: Nat Immunol
Title: RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development.
Volume: 7
Issue: 11
Pages: 1182-90
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Publication
26903241 | J:232930
First Author: Hu H
Year: 2016
Journal: J Exp Med
Title: Otud7b facilitates T cell activation and inflammatory responses by regulating Zap70 ubiquitination.
Volume: 213
Issue: 3
Pages: 399-414
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Publication
24908390 | J:258987
First Author: Au-Yeung BB
Year: 2014
Journal: Nat Immunol
Title: Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.
Volume: 15
Issue: 7
Pages: 687-94
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Publication
31911947 | J:288343
First Author: Thumkeo D
Year: 2020
Journal: Sci Adv
Title: mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse.
Volume: 6
Issue: 1
Pages: eaay2432
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Publication
16273097 | J:112654
First Author: Yokosuka T
Year: 2005
Journal: Nat Immunol
Title: Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.
Volume: 6
Issue: 12
Pages: 1253-62
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Publication
20332428 | J:165067
First Author: Saini M
Year: 2010
Journal: Sci Signal
Title: Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.
Volume: 3
Issue: 114
Pages: ra23
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Publication
21037577 | J:167326
First Author: Au-Yeung BB
Year: 2010
Journal: Nat Immunol
Title: A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity.
Volume: 11
Issue: 12
Pages: 1085-92
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Publication
20846526 | J:164659
First Author: Cha Y
Year: 2010
Journal: FEBS Lett
Title: SHP2 is a downstream target of ZAP70 to regulate JAK1/STAT3 and ERK signaling pathways in mouse embryonic stem cells.
Volume: 584
Issue: 19
Pages: 4241-6
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Publication
31019063 | J:276229
First Author: Matsuo T
Year: 2019
Journal: J Immunol
Title: Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation.
Volume: 202
Issue: 11
Pages: 3161-3172
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Publication
- | J:167119
     
First Author: Beutler B
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission 2011/01/07
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Publication
- | J:272864
     
First Author: Zhong X
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for want_to.
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Publication
11514606 | J:71098
First Author: Gong Q
Year: 2001
Journal: J Exp Med
Title: Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development.
Volume: 194
Issue: 4
Pages: 507-18
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Publication
14647385 | J:86607
First Author: Sakaguchi N
Year: 2003
Journal: Nature
Title: Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice.
Volume: 426
Issue: 6965
Pages: 454-60
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Publication
24266404 | J:211840
First Author: Siggs OM
Year: 2014
Journal: Immunology
Title: A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction.
Volume: 141
Issue: 4
Pages: 587-95
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Publication
17767948 | J:137446
First Author: Jakob T
Year: 2008
Journal: J Allergy Clin Immunol
Title: Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis.
Volume: 121
Issue: 1
Pages: 179-184.e7
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Publication
25136127 | J:214817
First Author: Au-Yeung BB
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A sharp T-cell antigen receptor signaling threshold for T-cell proliferation.
Volume: 111
Issue: 35
Pages: E3679-88
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Publication
15944285 | J:100876
First Author: Lysechko TL
Year: 2005
Journal: J Immunol
Title: Differential Src family kinase activity requirements for CD3 zeta phosphorylation/ZAP70 recruitment and CD3 epsilon phosphorylation.
Volume: 174
Issue: 12
Pages: 7807-14
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Publication
17785805 | J:152048
First Author: Chandok MR
Year: 2007
Journal: J Immunol
Title: A biochemical signature for rapid recall of memory CD4 T cells.
Volume: 179
Issue: 6
Pages: 3689-98
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Publication
27427418 | J:235142
First Author: Guerard S
Year: 2016
Journal: Am J Pathol
Title: Reactive Oxygen Species Regulate Innate But Not Adaptive Inflammation in ZAP70-Mutated SKG Arthritic Mice.
Volume: 186
Issue: 9
Pages: 2353-63
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Publication
27100879 | J:249206
First Author: Côme C
Year: 2016
Journal: PLoS One
Title: CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.
Volume: 11
Issue: 4
Pages: e0152996
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Publication
21248251 | J:169146
First Author: Peterson LK
Year: 2011
Journal: J Immunol
Title: SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.
Volume: 186
Issue: 4
Pages: 2273-81
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Publication
29980684 | J:268683
First Author: Zhao M
Year: 2018
Journal: Nat Commun
Title: Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.
Volume: 9
Issue: 1
Pages: 2627
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Publication
33974042 | J:322186
 
First Author: Nguyen TTT
Year: 2021
Journal: J Exp Med
Title: Cbl-b deficiency prevents functional but not phenotypic T cell anergy.
Volume: 218
Issue: 7
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Publication
18093540 | J:129169
First Author: Siggs OM
Year: 2007
Journal: Immunity
Title: Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.
Volume: 27
Issue: 6
Pages: 912-26
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Publication
19841086 | J:154166
First Author: Hsu LY
Year: 2009
Journal: J Exp Med
Title: A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity.
Volume: 206
Issue: 11
Pages: 2527-41
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Publication
15735649 | J:97608
First Author: Salvador JM
Year: 2005
Journal: Nat Immunol
Title: The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.
Volume: 6
Issue: 4
Pages: 396-402
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Publication
15735648 | J:97609
First Author: Salvador JM
Year: 2005
Journal: Nat Immunol
Title: Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.
Volume: 6
Issue: 4
Pages: 390-5
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Publication
25477210 | J:230916
First Author: Chiang YJ
Year: 2015
Journal: Int Immunol
Title: Regulation of T cell development by c-Cbl: essential role of Lck.
Volume: 27
Issue: 5
Pages: 245-51
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Publication
24584089 | J:209882
First Author: Roncagalli R
Year: 2014
Journal: Nat Immunol
Title: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Volume: 15
Issue: 4
Pages: 384-392
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Publication
20861360 | J:164718
First Author: White AJ
Year: 2010
Journal: J Immunol
Title: Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.
Volume: 185
Issue: 8
Pages: 4769-76
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Publication
31337738 | J:284364
 
First Author: Jun JE
Year: 2019
Journal: Sci Signal
Title: Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation.
Volume: 12
Issue: 591
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Publication
15699074 | J:96052
First Author: Round JL
Year: 2005
Journal: J Exp Med
Title: Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector function in T cells.
Volume: 201
Issue: 3
Pages: 419-30
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Publication
23620790 | J:200103
First Author: Chiang YJ
Year: 2013
Journal: PLoS One
Title: CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
Volume: 8
Issue: 4
Pages: e61761
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Protein Coding Gene
MGP_CAROLIEiJ_G0014045 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0015932 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0015916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0015871 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0015870 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0015703 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_99613 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0016323 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0015284 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0015675 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0015776 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0015778 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0015846 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0015798 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0016370 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0015067 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0015346 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0027291 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0014849 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
14985102 | J:88487
First Author: Kuroyama H
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Identification of a novel isoform of ZAP-70, truncated ZAP kinase.
Volume: 315
Issue: 4
Pages: 935-41
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Publication
9794398 | J:74974
First Author: Kadlecek TA
Year: 1998
Journal: J Immunol
Title: Differential requirements for ZAP-70 in TCR signaling and T cell development.
Volume: 161
Issue: 9
Pages: 4688-94
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Publication
31137740 | J:289320
 
First Author: Kugyelka R
Year: 2019
Journal: Cells
Title: ZAP-70 Regulates Autoimmune Arthritis via Alterations in T Cell Activation and Apoptosis.
Volume: 8
Issue: 5
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Publication
- | J:236698
     
First Author: Wang K-W
Year: 2016
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for waterfowl
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Publication
20644168 | J:162619
First Author: Tanaka S
Year: 2010
Journal: J Immunol
Title: Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function.
Volume: 185
Issue: 4
Pages: 2295-305
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Publication
24241693 | J:208981
First Author: Wencker M
Year: 2014
Journal: Nat Immunol
Title: Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.
Volume: 15
Issue: 1
Pages: 80-7
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Publication
18711120 | J:141043
First Author: Wakasa-Morimoto C
Year: 2008
Journal: Int Immunol
Title: Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis.
Volume: 20
Issue: 10
Pages: 1331-42
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Publication
31455730 | J:279361
First Author: Ashouri JF
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
Volume: 116
Issue: 37
Pages: 18517-18527
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Publication
14770180 | J:88469
First Author: Liu X
Year: 2004
Journal: Nat Immunol
Title: Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.
Volume: 5
Issue: 3
Pages: 280-8
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Publication
- | J:254832
     
First Author: Zeng M
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for mesa_verde
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Publication
10190908 | J:111810
First Author: Ashe JM
Year: 1999
Journal: J Exp Med
Title: ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).
Volume: 189
Issue: 7
Pages: 1163-8
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Publication
- | J:174837
   
First Author: Beutler B
Year: 2011
Journal: MGI Direct Data Submission
Title: Direct Data Submission
Volume: v
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Publication
- | J:254831
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for wanna4
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Publication
11238119 | J:68078
First Author: Iwabuchi K
Year: 2001
Journal: Blood
Title: Defective development of NK1.1+ T-cell antigen receptor alphabeta+ cells in zeta-associated protein 70 null mice with an accumulation of NK1.1+ CD3- NK-like cells in the thymus.
Volume: 97
Issue: 6
Pages: 1765-75
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Publication
23305740 | J:195435
First Author: de Barros SC
Year: 2013
Journal: Blood
Title: Intrathymic progenitor cell transplantation across histocompatibility barriers results in the persistence of early thymic progenitors and T-cell differentiation.
Volume: 121
Issue: 11
Pages: 2144-53
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Publication
15740591 | J:109808
First Author: Endo Y
Year: 2005
Journal: Exp Dermatol
Title: Zeta-chain-associated protein-70 molecule is essential for the proliferation and the final maturation of dendritic epidermal T cells.
Volume: 14
Issue: 3
Pages: 188-93
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Publication
10963813 | J:63739
First Author: Tone S
Year: 2000
Journal: Immunol Lett
Title: Induction of NK1.1(+) alpha beta TCR(+) T cells by bypassing TCR signals in ZAP-70 deficient mice.
Volume: 73
Issue: 1
Pages: 65-9
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Publication
- | J:225043
     
First Author: Choi JH
Year: 2015
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for wanna2
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Publication
- | J:254830
     
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for wanna3
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Publication
9021148 | J:38064
First Author: Saito T
Year: 1997
Journal: Mamm Genome
Title: Localization of Zap70, the gene for a T cell-specific protein tyrosine kinase, to mouse and rat chromosomes by fluorescence in situ hybridization and molecular genetic linkage analyses.
Volume: 8
Issue: 1
Pages: 45-6
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Publication
16116204 | J:113210
First Author: Davanture S
Year: 2005
Journal: J Immunol
Title: Selective defect in antigen-induced TCR internalization at the immune synapse of CD8 T cells bearing the ZAP-70(Y292F) mutation.
Volume: 175
Issue: 5
Pages: 3140-9
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Publication
23858460 | J:198776
First Author: Sinclair C
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system.
Volume: 110
Issue: 31
Pages: E2905-14
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876826
Stage: TS26
Assay Id: MGI:5013619
Age: embryonic day 18.0
Specimen Label: Fetal thymus
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876828
Stage: TS28
Assay Id: MGI:5013619
Age: postnatal month 3
Specimen Label: Adult thymus
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689426
Stage: TS26
Assay Id: MGI:5013619
Age: embryonic day 18.0
Specimen Label: Fetal brain
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:5013619
Age: postnatal month 3
Specimen Label: Adult brain
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1876728
Stage: TS28
Assay Id: MGI:5013619
Age: postnatal month 3
Specimen Label: Adult spleen
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684628
Stage: TS28
Assay Id: MGI:5013619
Age: postnatal month 3
Specimen Label: Adult liver
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
     
Probe: MGI:5013617
Assay Type: Northern blot
Annotation Date: 2011-07-08
Strength: Absent
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5013619
Age: postnatal month 3
Specimen Label: Adult testis
Detected: false
Specimen Num: 8
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