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Search results 1 to 100 out of 190 for Zbp1

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Gene
81030 | ZBP1
Type: gene
Organism: human
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Gene
101732530 | zbp1
Type: gene
Organism: frog, western clawed
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Gene
171091 | Zbp1
Type: gene
Organism: rat
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Gene
746148 | ZBP1
Type: gene
Organism: chimpanzee
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Gene
611825 | ZBP1
Type: gene
Organism: dog, domestic
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Gene
508333 | ZBP1
Type: gene
Organism: cattle
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Gene
696090 | ZBP1
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR042361 | ZBP1
Type: Family
Description: Z-DNA-binding protein 1 (ZBP1), also known as DAI (DNA-dependent activator of IFN regulatory factors), is a cytosolic DNA sensor that activates the innate immune system [].
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Protein Coding Gene
MGI:1927449 | Zbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17618271 | J:123411
First Author: Takaoka A
Year: 2007
Journal: Nature
Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Volume: 448
Issue: 7152
Pages: 501-5
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Publication
31076724 | J:279198
     
First Author: Yang D
Year: 2019
Journal: Cell Mol Immunol
Title: ZBP1 mediates interferon-induced necroptosis.
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Publication
33976222 | J:306106
First Author: Baik JY
Year: 2021
Journal: Nat Commun
Title: ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.
Volume: 12
Issue: 1
Pages: 2666
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Publication
35859175 | J:330287
First Author: de Reuver R
Year: 2022
Journal: Nature
Title: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
Volume: 607
Issue: 7920
Pages: 784-789
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Publication
21964071 | J:180195
First Author: Donnelly CJ
Year: 2011
Journal: EMBO J
Title: Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity.
Volume: 30
Issue: 22
Pages: 4665-77
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Publication
36191211 | J:353327
First Author: Rodriguez DA
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Caspase-8 and FADD prevent spontaneous ZBP1 expression and necroptosis.
Volume: 119
Issue: 41
Pages: e2207240119
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Publication
37352855 | J:338214
First Author: Lei Y
Year: 2023
Journal: Cell
Title: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Volume: 186
Issue: 14
Pages: 3013-3032.e22
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Publication
35666872 | J:341787
First Author: Muendlein HI
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF.
Volume: 119
Issue: 24
Pages: e2113872119
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Publication
33109609 | J:300942
First Author: Banoth B
Year: 2020
Journal: J Biol Chem
Title: ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).
Volume: 295
Issue: 52
Pages: 18276-18283
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Publication
32315377 | J:294928
 
First Author: Devos M
Year: 2020
Journal: J Exp Med
Title: Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
Volume: 217
Issue: 7
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Publication
33397971 | J:300952
First Author: Muendlein HI
Year: 2021
Journal: Nat Commun
Title: ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1.
Volume: 12
Issue: 1
Pages: 86
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Publication
31630209 | J:289451
First Author: Momota M
Year: 2020
Journal: Int Immunol
Title: ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity.
Volume: 32
Issue: 3
Pages: 203-212
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Publication
38548850 | J:348283
First Author: Solon M
Year: 2024
Journal: Cell Death Differ
Title: ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1.
Volume: 31
Issue: 5
Pages: 672-682
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Publication
34471287 | J:361095
First Author: Lee S
Year: 2021
Journal: Nature
Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Volume: 597
Issue: 7876
Pages: 415-419
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Publication
32350114 | J:295921
First Author: Kesavardhana S
Year: 2020
Journal: J Biol Chem
Title: The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.
Volume: 295
Issue: 24
Pages: 8325-8330
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Publication
30635240 | J:279203
First Author: Daniels BP
Year: 2019
Journal: Immunity
Title: The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Volume: 50
Issue: 1
Pages: 64-76.e4
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Protein
Q9QY24
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
A2APF7
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Publication
32096322 | J:302596
First Author: Koehler HS
Year: 2020
Journal: FEBS J
Title: Recognizing limits of Z-nucleic acid binding protein (ZBP1/DAI/DLM1) function.
Volume: 287
Issue: 20
Pages: 4362-4369
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Publication
31572318 | J:281883
 
First Author: Rothan HA
Year: 2019
Journal: Front Microbiol
Title: Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis.
Volume: 10
Pages: 2089
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Publication
22423968 | J:289066
First Author: Upton JW
Year: 2012
Journal: Cell Host Microbe
Title: DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.
Volume: 11
Issue: 3
Pages: 290-7
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Publication
35065966 | J:321601
First Author: Wang X
Year: 2022
Journal: J Biol Chem
Title: TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.
Volume: 298
Issue: 3
Pages: 101611
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Publication
28716805 | J:252669
First Author: Maelfait J
Year: 2017
Journal: EMBO J
Title: Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Volume: 36
Issue: 17
Pages: 2529-2543
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Publication
11524677 | J:74605
First Author: Schwartz T
Year: 2001
Journal: Nat Struct Biol
Title: Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Volume: 8
Issue: 9
Pages: 761-5
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Publication
32200799 | J:289082
First Author: Zhang T
Year: 2020
Journal: Cell
Title: Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis.
Volume: 180
Issue: 6
Pages: 1115-1129.e13
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Publication
30050136 | J:289074
First Author: Guo H
Year: 2018
Journal: Cell Death Dis
Title: Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.
Volume: 9
Issue: 8
Pages: 816
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Publication
35614224 | J:330230
First Author: Zhang T
Year: 2022
Journal: Nature
Title: ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
Volume: 606
Issue: 7914
Pages: 594-602
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Publication
28634194 | J:244643
First Author: Kesavardhana S
Year: 2017
Journal: J Exp Med
Title: ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.
Volume: 214
Issue: 8
Pages: 2217-2229
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Publication
34686350 | J:320929
First Author: Karki R
Year: 2021
Journal: Cell Rep
Title: ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Volume: 37
Issue: 3
Pages: 109858
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Publication
32298652 | J:290292
First Author: Zheng M
Year: 2020
Journal: Cell
Title: Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Volume: 181
Issue: 3
Pages: 674-687.e13
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Publication
27819681 | J:242991
First Author: Lin J
Year: 2016
Journal: Nature
Title: RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Volume: 540
Issue: 7631
Pages: 124-128
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Publication
38744293 | J:349097
     
First Author: Imai T
Year: 2024
Journal: Immunity
Title: The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation.
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Publication
27917412 | J:290369
 
First Author: Kuriakose T
Year: 2016
Journal: Sci Immunol
Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Volume: 1
Issue: 2
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Publication
35859176 | J:331944
First Author: Jiao H
Year: 2022
Journal: Nature
Title: ADAR1 averts fatal type I interferon induction by ZBP1.
Volume: 607
Issue: 7920
Pages: 776-783
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Publication
35859177 | J:331943
First Author: Hubbard NW
Year: 2022
Journal: Nature
Title: ADAR1 mutation causes ZBP1-dependent immunopathology.
Volume: 607
Issue: 7920
Pages: 769-775
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Publication
27819682 | J:242990
First Author: Newton K
Year: 2016
Journal: Nature
Title: RIPK1 inhibits ZBP1-driven necroptosis during development.
Volume: 540
Issue: 7631
Pages: 129-133
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Publication
31358656 | J:279199
First Author: Ingram JP
Year: 2019
Journal: J Immunol
Title: ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.
Volume: 203
Issue: 5
Pages: 1348-1355
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Protein Coding Gene
MGP_CAROLIEiJ_G0024748 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026673 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026131 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026650 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026189 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025668 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10564822 | J:58659
First Author: Fu Y
Year: 1999
Journal: Gene
Title: Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.
Volume: 240
Issue: 1
Pages: 157-63
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Publication
29073079 | J:289445
First Author: Koehler H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3.
Volume: 114
Issue: 43
Pages: 11506-11511
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Publication
31655343 | J:290405
 
First Author: Du XK
Year: 2019
Journal: Int Immunopharmacol
Title: Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1.
Volume: 77
Pages: 105944
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848867
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848867
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848867
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848867
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848867
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848867
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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Publication
32296175 | J:289452
First Author: Jiao H
Year: 2020
Journal: Nature
Title: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Volume: 580
Issue: 7803
Pages: 391-395
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Publication
27746097 | J:289096
First Author: Thapa RJ
Year: 2016
Journal: Cell Host Microbe
Title: DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
Volume: 20
Issue: 5
Pages: 674-681
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Publication
28607035 | J:289444
First Author: Sridharan H
Year: 2017
Journal: EMBO Rep
Title: Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis.
Volume: 18
Issue: 8
Pages: 1429-1441
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Publication
19590578 | J:157332
First Author: Rebsamen M
Year: 2009
Journal: EMBO Rep
Title: DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Volume: 10
Issue: 8
Pages: 916-22
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Publication
38157451 | J:352540
First Author: Yang X
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Excessive nucleic acid R-loops induce mitochondria-dependent epithelial cell necroptosis and drive spontaneous intestinal inflammation.
Volume: 121
Issue: 1
Pages: e2307395120
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Publication
29581256 | J:261388
First Author: Chen D
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Volume: 115
Issue: 15
Pages: 3930-3935
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Publication
23251783 | J:197877
 
First Author: Ferguson BJ
Year: 2012
Journal: Elife
Title: DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
Volume: 1
Pages: e00047
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Publication
20890285 | J:166541
First Author: Unterholzner L
Year: 2010
Journal: Nat Immunol
Title: IFI16 is an innate immune sensor for intracellular DNA.
Volume: 11
Issue: 11
Pages: 997-1004
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Publication
18256672 | J:132662
First Author: Ishii KJ
Year: 2008
Journal: Nature
Title: TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Volume: 451
Issue: 7179
Pages: 725-9
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Publication
24717539 | J:213251
 
First Author: Imanishi T
Year: 2014
Journal: Nat Commun
Title: Nucleic acid sensing by T cells initiates Th2 cell differentiation.
Volume: 5
Pages: 3566
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Publication
24335288 | J:205493
First Author: Ono C
Year: 2014
Journal: J Virol
Title: Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
Volume: 88
Issue: 4
Pages: 2157-67
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Publication
34380029 | J:310901
First Author: de Reuver R
Year: 2021
Journal: Cell Rep
Title: ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
Volume: 36
Issue: 6
Pages: 109500
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Publication
32723479 | J:302391
   
First Author: Piersma SJ
Year: 2020
Journal: Elife
Title: Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
Volume: 9
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Publication
19652017 | J:152182
First Author: McWhirter SM
Year: 2009
Journal: J Exp Med
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Volume: 206
Issue: 9
Pages: 1899-911
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Publication
39500322 | J:359312
First Author: Jena KK
Year: 2024
Journal: Cell
Title: Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.
Volume: 187
Issue: 26
Pages: 7533-7550.e23
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Publication
29786074 | J:275025
First Author: Sarhan J
Year: 2019
Journal: Cell Death Differ
Title: Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
Volume: 26
Issue: 2
Pages: 332-347
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Publication
21765404 | J:174513
First Author: Marichal T
Year: 2011
Journal: Nat Med
Title: DNA released from dying host cells mediates aluminum adjuvant activity.
Volume: 17
Issue: 8
Pages: 996-1002
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Publication
21903422 | J:176666
First Author: Li S
Year: 2011
Journal: Immunity
Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Volume: 35
Issue: 3
Pages: 426-40
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Publication
24557836 | J:209137
First Author: Newton K
Year: 2014
Journal: Science
Title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Volume: 343
Issue: 6177
Pages: 1357-60
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Publication
21820332 | J:175845
First Author: Sharma S
Year: 2011
Journal: Immunity
Title: Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Volume: 35
Issue: 2
Pages: 194-207
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Publication
26682986 | J:257995
First Author: Xu RH
Year: 2015
Journal: Immunity
Title: Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
Volume: 43
Issue: 6
Pages: 1148-59
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Publication
19158679 | J:145965
First Author: Bürckstümmer T
Year: 2009
Journal: Nat Immunol
Title: An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Volume: 10
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