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Search results 1 to 100 out of 175 for Zbp1

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Gene
81030 | ZBP1
Type: gene
Organism: human
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Gene
611825 | ZBP1
Type: gene
Organism: dog, domestic
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Gene
508333 | ZBP1
Type: gene
Organism: cattle
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Gene
696090 | ZBP1
Type: gene
Organism: macaque, rhesus
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Gene
101732530 | zbp1
Type: gene
Organism: frog, western clawed
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Gene
171091 | Zbp1
Type: gene
Organism: rat
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Gene
746148 | ZBP1
Type: gene
Organism: chimpanzee
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Protein Domain
IPR042361 | ZBP1
Type: Family
Description: Z-DNA-binding protein 1 (ZBP1), also known as DAI (DNA-dependent activator of IFN regulatory factors), is a cytosolic DNA sensor that activates the innate immune system [].
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Protein Coding Gene
MGI:1927449 | Zbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17618271 | J:123411
First Author: Takaoka A
Year: 2007
Journal: Nature
Title: DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
Volume: 448
Issue: 7152
Pages: 501-5
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Publication
31076724 | J:279198
     
First Author: Yang D
Year: 2019
Journal: Cell Mol Immunol
Title: ZBP1 mediates interferon-induced necroptosis.
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Publication
33976222 | J:306106
First Author: Baik JY
Year: 2021
Journal: Nat Commun
Title: ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.
Volume: 12
Issue: 1
Pages: 2666
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Publication
35859175 | J:330287
First Author: de Reuver R
Year: 2022
Journal: Nature
Title: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
Volume: 607
Issue: 7920
Pages: 784-789
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Publication
21964071 | J:180195
First Author: Donnelly CJ
Year: 2011
Journal: EMBO J
Title: Limited availability of ZBP1 restricts axonal mRNA localization and nerve regeneration capacity.
Volume: 30
Issue: 22
Pages: 4665-77
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Publication
37352855 | J:338214
First Author: Lei Y
Year: 2023
Journal: Cell
Title: Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity.
Volume: 186
Issue: 14
Pages: 3013-3032.e22
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Publication
35666872 | J:341787
First Author: Muendlein HI
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: ZBP1 promotes inflammatory responses downstream of TLR3/TLR4 via timely delivery of RIPK1 to TRIF.
Volume: 119
Issue: 24
Pages: e2113872119
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Publication
33109609 | J:300942
First Author: Banoth B
Year: 2020
Journal: J Biol Chem
Title: ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).
Volume: 295
Issue: 52
Pages: 18276-18283
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Publication
32315377 | J:294928
 
First Author: Devos M
Year: 2020
Journal: J Exp Med
Title: Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
Volume: 217
Issue: 7
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Publication
33397971 | J:300952
First Author: Muendlein HI
Year: 2021
Journal: Nat Commun
Title: ZBP1 promotes LPS-induced cell death and IL-1β release via RHIM-mediated interactions with RIPK1.
Volume: 12
Issue: 1
Pages: 86
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Publication
31630209 | J:289451
First Author: Momota M
Year: 2020
Journal: Int Immunol
Title: ZBP1 governs the inflammasome-independent IL-1α and neutrophil inflammation that play a dual role in anti-influenza virus immunity.
Volume: 32
Issue: 3
Pages: 203-212
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Publication
32350114 | J:295921
First Author: Kesavardhana S
Year: 2020
Journal: J Biol Chem
Title: The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development.
Volume: 295
Issue: 24
Pages: 8325-8330
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Publication
30635240 | J:279203
First Author: Daniels BP
Year: 2019
Journal: Immunity
Title: The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.
Volume: 50
Issue: 1
Pages: 64-76.e4
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Protein
Q9QY24
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Protein
A2APF7
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
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Publication
32096322 | J:302596
First Author: Koehler HS
Year: 2020
Journal: FEBS J
Title: Recognizing limits of Z-nucleic acid binding protein (ZBP1/DAI/DLM1) function.
Volume: 287
Issue: 20
Pages: 4362-4369
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Publication
31572318 | J:281883
 
First Author: Rothan HA
Year: 2019
Journal: Front Microbiol
Title: Z-DNA-Binding Protein 1 Is Critical for Controlling Virus Replication and Survival in West Nile Virus Encephalitis.
Volume: 10
Pages: 2089
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Publication
22423968 | J:289066
First Author: Upton JW
Year: 2012
Journal: Cell Host Microbe
Title: DAI/ZBP1/DLM-1 complexes with RIP3 to mediate virus-induced programmed necrosis that is targeted by murine cytomegalovirus vIRA.
Volume: 11
Issue: 3
Pages: 290-7
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Publication
35065966 | J:321601
First Author: Wang X
Year: 2022
Journal: J Biol Chem
Title: TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.
Volume: 298
Issue: 3
Pages: 101611
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Publication
28716805 | J:252669
First Author: Maelfait J
Year: 2017
Journal: EMBO J
Title: Sensing of viral and endogenous RNA by ZBP1/DAI induces necroptosis.
Volume: 36
Issue: 17
Pages: 2529-2543
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Publication
32200799 | J:289082
First Author: Zhang T
Year: 2020
Journal: Cell
Title: Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis.
Volume: 180
Issue: 6
Pages: 1115-1129.e13
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Publication
11524677 | J:74605
First Author: Schwartz T
Year: 2001
Journal: Nat Struct Biol
Title: Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.
Volume: 8
Issue: 9
Pages: 761-5
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Publication
30050136 | J:289074
First Author: Guo H
Year: 2018
Journal: Cell Death Dis
Title: Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1.
Volume: 9
Issue: 8
Pages: 816
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Publication
35614224 | J:330230
First Author: Zhang T
Year: 2022
Journal: Nature
Title: ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
Volume: 606
Issue: 7914
Pages: 594-602
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Publication
28634194 | J:244643
First Author: Kesavardhana S
Year: 2017
Journal: J Exp Med
Title: ZBP1/DAI ubiquitination and sensing of influenza vRNPs activate programmed cell death.
Volume: 214
Issue: 8
Pages: 2217-2229
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Publication
32298652 | J:290292
First Author: Zheng M
Year: 2020
Journal: Cell
Title: Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Volume: 181
Issue: 3
Pages: 674-687.e13
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Publication
34686350 | J:320929
First Author: Karki R
Year: 2021
Journal: Cell Rep
Title: ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis.
Volume: 37
Issue: 3
Pages: 109858
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Publication
27819681 | J:242991
First Author: Lin J
Year: 2016
Journal: Nature
Title: RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation.
Volume: 540
Issue: 7631
Pages: 124-128
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Publication
35859176 | J:331944
First Author: Jiao H
Year: 2022
Journal: Nature
Title: ADAR1 averts fatal type I interferon induction by ZBP1.
Volume: 607
Issue: 7920
Pages: 776-783
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Publication
27917412 | J:290369
 
First Author: Kuriakose T
Year: 2016
Journal: Sci Immunol
Title: ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways.
Volume: 1
Issue: 2
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Publication
35859177 | J:331943
First Author: Hubbard NW
Year: 2022
Journal: Nature
Title: ADAR1 mutation causes ZBP1-dependent immunopathology.
Volume: 607
Issue: 7920
Pages: 769-775
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Publication
27819682 | J:242990
First Author: Newton K
Year: 2016
Journal: Nature
Title: RIPK1 inhibits ZBP1-driven necroptosis during development.
Volume: 540
Issue: 7631
Pages: 129-133
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Publication
31358656 | J:279199
First Author: Ingram JP
Year: 2019
Journal: J Immunol
Title: ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1.
Volume: 203
Issue: 5
Pages: 1348-1355
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Protein Coding Gene
MGP_CAROLIEiJ_G0024748 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0026955 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0026922 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0026893 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0026931 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0026673 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1927449 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0027378 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0026131 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0026650 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0026788 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0026754 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0026889 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0026773 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027435 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0025868 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026204 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0026189 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025668 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10564822 | J:58659
First Author: Fu Y
Year: 1999
Journal: Gene
Title: Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display.
Volume: 240
Issue: 1
Pages: 157-63
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Publication
29073079 | J:289445
First Author: Koehler H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3.
Volume: 114
Issue: 43
Pages: 11506-11511
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Publication
31655343 | J:290405
 
First Author: Du XK
Year: 2019
Journal: Int Immunopharmacol
Title: Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1.
Volume: 77
Pages: 105944
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619815
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848867
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619817
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848867
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1619819
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848867
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610515
Pattern: Not Specified
Stage: TS15
Assay Id: MGI:4848867
Age: embryonic day 9.5
Specimen Label: Table S4 - E9.5
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610517
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:4848867
Age: embryonic day 10.5
Specimen Label: Table S4 - E10.5
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4845204
Assay Type: RNA in situ
Annotation Date: 2010-12-22
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1610519
Pattern: Not Specified
Stage: TS19
Assay Id: MGI:4848867
Age: embryonic day 11.5
Specimen Label: Table S4 - E11.5
Detected: true
Specimen Num: 3
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Publication
32296175 | J:289452
First Author: Jiao H
Year: 2020
Journal: Nature
Title: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Volume: 580
Issue: 7803
Pages: 391-395
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Publication
27746097 | J:289096
First Author: Thapa RJ
Year: 2016
Journal: Cell Host Microbe
Title: DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
Volume: 20
Issue: 5
Pages: 674-681
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Publication
28607035 | J:289444
First Author: Sridharan H
Year: 2017
Journal: EMBO Rep
Title: Murine cytomegalovirus IE3-dependent transcription is required for DAI/ZBP1-mediated necroptosis.
Volume: 18
Issue: 8
Pages: 1429-1441
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Publication
19590578 | J:157332
First Author: Rebsamen M
Year: 2009
Journal: EMBO Rep
Title: DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.
Volume: 10
Issue: 8
Pages: 916-22
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Publication
23251783 | J:197877
 
First Author: Ferguson BJ
Year: 2012
Journal: Elife
Title: DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
Volume: 1
Pages: e00047
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Publication
29581256 | J:261388
First Author: Chen D
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Volume: 115
Issue: 15
Pages: 3930-3935
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Publication
18256672 | J:132662
First Author: Ishii KJ
Year: 2008
Journal: Nature
Title: TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Volume: 451
Issue: 7179
Pages: 725-9
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Publication
24717539 | J:213251
 
First Author: Imanishi T
Year: 2014
Journal: Nat Commun
Title: Nucleic acid sensing by T cells initiates Th2 cell differentiation.
Volume: 5
Pages: 3566
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Publication
24335288 | J:205493
First Author: Ono C
Year: 2014
Journal: J Virol
Title: Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
Volume: 88
Issue: 4
Pages: 2157-67
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Publication
34380029 | J:310901
First Author: de Reuver R
Year: 2021
Journal: Cell Rep
Title: ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
Volume: 36
Issue: 6
Pages: 109500
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Publication
20890285 | J:166541
First Author: Unterholzner L
Year: 2010
Journal: Nat Immunol
Title: IFI16 is an innate immune sensor for intracellular DNA.
Volume: 11
Issue: 11
Pages: 997-1004
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Publication
29786074 | J:275025
First Author: Sarhan J
Year: 2019
Journal: Cell Death Differ
Title: Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
Volume: 26
Issue: 2
Pages: 332-347
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Publication
19652017 | J:152182
First Author: McWhirter SM
Year: 2009
Journal: J Exp Med
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Volume: 206
Issue: 9
Pages: 1899-911
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Publication
21765404 | J:174513
First Author: Marichal T
Year: 2011
Journal: Nat Med
Title: DNA released from dying host cells mediates aluminum adjuvant activity.
Volume: 17
Issue: 8
Pages: 996-1002
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Publication
32723479 | J:302391
   
First Author: Piersma SJ
Year: 2020
Journal: Elife
Title: Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
Volume: 9
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Publication
21903422 | J:176666
First Author: Li S
Year: 2011
Journal: Immunity
Title: Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Volume: 35
Issue: 3
Pages: 426-40
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Publication
24557836 | J:209137
First Author: Newton K
Year: 2014
Journal: Science
Title: Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis.
Volume: 343
Issue: 6177
Pages: 1357-60
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Publication
21820332 | J:175845
First Author: Sharma S
Year: 2011
Journal: Immunity
Title: Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome.
Volume: 35
Issue: 2
Pages: 194-207
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Publication
26682986 | J:257995
First Author: Xu RH
Year: 2015
Journal: Immunity
Title: Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection.
Volume: 43
Issue: 6
Pages: 1148-59
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Publication
19158679 | J:145965
First Author: Bürckstümmer T
Year: 2009
Journal: Nat Immunol
Title: An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome.
Volume: 10
Issue: 3
Pages: 266-72
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Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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