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Search results 1 to 100 out of 860 for Zp3

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0.048s
Type Details Score
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Danio rerio
Gene
Type: gene
Organism: Rattus norvegicus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Domain
Type: Family
Description: At fertilization, mammalian sperm binds to the extracellular zona pellucida that surrounds ovulated eggs. The zona pellucida is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4 []. Fish eggs are also surrounded by an envelope, which consists of a few proteins homologous to mammalian ZP1, ZP3, and ZP4 [, ]. Glycoprotein ZP3 is essential for normal fertility []. It promotes fertilization by recognizing sperm binding and activating the acrosome reaction [, ]. It is also required for germinal vesicle breakdown in oocyte meiosis [].
Publication
First Author: Del Giacco L
Year: 2000
Journal: Dev Genes Evol
Title: Identification and spatial distribution of the mRNA encoding an egg envelope component of the Cyprinid zebrafish, Danio rerio, homologous to the mammalian ZP3 (ZPC).
Volume: 210
Issue: 1
Pages: 41-6
Gene
Type: gene
Organism: Homo sapiens
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Rankin TL
Year: 1998
Journal: Development
Title: Human ZP3 restores fertility in Zp3 null mice without affecting order-specific sperm binding.
Volume: 125
Issue: 13
Pages: 2415-24
Gene
Type: gene
Organism: Homo sapiens
Publication
First Author: Zhao M
Year: 2003
Journal: Mol Cell Biol
Title: Mutation of a conserved hydrophobic patch prevents incorporation of ZP3 into the zona pellucida surrounding mouse eggs.
Volume: 23
Issue: 24
Pages: 8982-91
Publication
First Author: Hoodbhoy T
Year: 2006
Journal: Mol Cell Biol
Title: ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida.
Volume: 26
Issue: 21
Pages: 7991-8
Publication
First Author: Tang F
Year: 2007
Journal: Genes Dev
Title: Maternal microRNAs are essential for mouse zygotic development.
Volume: 21
Issue: 6
Pages: 644-8
Publication
First Author: Yu C
Year: 2013
Journal: Science
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Volume: 342
Issue: 6165
Pages: 1518-21
Publication  
First Author: Gao LL
Year: 2017
Journal: Sci Rep
Title: ZP3 is Required for Germinal Vesicle Breakdown in Mouse Oocyte Meiosis.
Volume: 7
Pages: 41272
Publication
First Author: Chen T
Year: 2017
Journal: Am J Hum Genet
Title: A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility.
Volume: 101
Issue: 3
Pages: 459-465
Publication
First Author: Florman HM
Year: 1985
Journal: Cell
Title: O-linked oligosaccharides of mouse egg ZP3 account for its sperm receptor activity.
Volume: 41
Issue: 1
Pages: 313-24
Publication
First Author: Leyton L
Year: 1989
Journal: J Cell Biol
Title: Evidence that aggregation of mouse sperm receptors by ZP3 triggers the acrosome reaction.
Volume: 108
Issue: 6
Pages: 2163-8
Publication
First Author: Zhao M
Year: 2002
Journal: Mol Cell Biol
Title: Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice.
Volume: 22
Issue: 9
Pages: 3111-20
Publication
First Author: Borillo J
Year: 2008
Journal: J Reprod Immunol
Title: Antibodies to two ZP3 B cell epitopes affect zona pellucida assembly.
Volume: 78
Issue: 2
Pages: 149-57
Publication
First Author: Beebe SJ
Year: 1992
Journal: Dev Biol
Title: Recombinant mouse ZP3 inhibits sperm binding and induces the acrosome reaction.
Volume: 151
Issue: 1
Pages: 48-54
Publication
First Author: Jungnickel MK
Year: 2007
Journal: Dev Biol
Title: Phosphoinositide-dependent pathways in mouse sperm are regulated by egg ZP3 and drive the acrosome reaction.
Volume: 304
Issue: 1
Pages: 116-26
Publication
First Author: Kimura J
Year: 1994
Journal: Cell Mol Biol (Noisy-le-grand)
Title: Localization of ZP3 mRNA in mouse ovary by non-radioactive in situ hybridization with digoxigenin-labelled cDNA.
Volume: 40
Issue: 8
Pages: 1097-101
Publication
First Author: Liu W
Year: 2017
Journal: Hum Genet
Title: Dosage effects of ZP2 and ZP3 heterozygous mutations cause human infertility.
Volume: 136
Issue: 8
Pages: 975-985
Publication
First Author: Monné M
Year: 2008
Journal: Nature
Title: Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats.
Volume: 456
Issue: 7222
Pages: 653-7
Publication
First Author: Kinloch RA
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Mapping the mouse ZP3 combining site for sperm by exon swapping and site-directed mutagenesis.
Volume: 92
Issue: 1
Pages: 263-7
Publication
First Author: Jimenez-Movilla M
Year: 2011
Journal: J Cell Sci
Title: ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida.
Volume: 124
Issue: Pt 6
Pages: 940-50
Publication
First Author: Rankin T
Year: 1996
Journal: Development
Title: Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile.
Volume: 122
Issue: 9
Pages: 2903-10
Publication
First Author: O'Toole CM
Year: 2000
Journal: Mol Biol Cell
Title: Ca(2+) entry through store-operated channels in mouse sperm is initiated by egg ZP3 and drives the acrosome reaction.
Volume: 11
Issue: 5
Pages: 1571-84
Publication
First Author: Thall AD
Year: 1995
Journal: J Biol Chem
Title: Oocyte Gal alpha 1,3Gal epitopes implicated in sperm adhesion to the zona pellucida glycoprotein ZP3 are not required for fertilization in the mouse.
Volume: 270
Issue: 37
Pages: 21437-40
Publication
First Author: El-Mestrah M
Year: 2002
Journal: Biol Reprod
Title: Subcellular distribution of ZP1, ZP2, and ZP3 glycoproteins during folliculogenesis and demonstration of their topographical disposition within the zona matrix of mouse ovarian oocytes.
Volume: 66
Issue: 4
Pages: 866-76
Publication
First Author: Avella MA
Year: 2014
Journal: J Cell Biol
Title: A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans.
Volume: 205
Issue: 6
Pages: 801-9
Publication
First Author: Rankin TL
Year: 2003
Journal: Dev Cell
Title: Fertility and taxon-specific sperm binding persist after replacement of mouse sperm receptors with human homologs.
Volume: 5
Issue: 1
Pages: 33-43
Protein
Organism: Mus musculus
Length: 80  
Fragment?: true
Protein
Organism: Mus musculus
Length: 136  
Fragment?: true
Protein
Organism: Mus musculus
Length: 80  
Fragment?: true
Protein
Organism: Mus musculus
Length: 80  
Fragment?: true
Protein
Organism: Mus musculus
Length: 80  
Fragment?: true
Publication
First Author: Xu ZG
Year: 2003
Journal: Hepatology
Title: A novel liver-specific zona pellucida domain containing protein that is expressed rarely in hepatocellular carcinoma.
Volume: 38
Issue: 3
Pages: 735-44
Publication  
First Author: Litscher ES
Year: 2018
Journal: Curr Top Dev Biol
Title: The Fish Egg's Zona Pellucida.
Volume: 130
Pages: 275-305
Publication  
First Author: Gupta SK
Year: 2015
Journal: J Reprod Immunol
Title: Role of zona pellucida glycoproteins during fertilization in humans.
Volume: 108
Pages: 90-7
Protein
Organism: Mus musculus
Length: 82  
Fragment?: true
Protein
Organism: Mus musculus
Length: 82  
Fragment?: true
Protein
Organism: Mus musculus
Length: 82  
Fragment?: true
Protein
Organism: Mus musculus
Length: 82  
Fragment?: true
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Protein
Organism: Mus musculus
Length: 424  
Fragment?: false
Publication
First Author: Zhang X
Year: 1997
Journal: Biol Reprod
Title: Antibody responses and infertility in mice following oral immunization with attenuated Salmonella typhimurium expressing recombinant murine ZP3.
Volume: 56
Issue: 1
Pages: 33-41
Publication
First Author: Kinloch RA
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: Primary structure of the mouse sperm receptor polypeptide determined by genomic cloning.
Volume: 85
Issue: 17
Pages: 6409-13
Publication
First Author: Philpott CC
Year: 1987
Journal: Dev Biol
Title: Oocyte-specific expression and developmental regulation of ZP3, the sperm receptor of the mouse zona pellucida.
Volume: 121
Issue: 2
Pages: 568-75
Publication
First Author: Kolluri SK
Year: 1995
Journal: Reprod Fertil Dev
Title: Nucleotide sequence of cDNA encoding bonnet monkey (Macaca radiata) zona pellucida glycoprotein-ZP3.
Volume: 7
Issue: 5
Pages: 1209-12
Publication
First Author: Ringuette MJ
Year: 1988
Journal: Dev Biol
Title: Molecular analysis of cDNA coding for ZP3, a sperm binding protein of the mouse zona pellucida.
Volume: 127
Issue: 2
Pages: 287-95
Publication
First Author: O'Leary S
Year: 2008
Journal: Biol Reprod
Title: Immunization with recombinant murine cytomegalovirus expressing murine zona pellucida 3 causes permanent infertility in BALB/c mice due to follicle depletion and ovulation failure.
Volume: 79
Issue: 5
Pages: 849-60
Publication
First Author: Lloyd ML
Year: 2010
Journal: J Autoimmun
Title: Immunoglobulin to zona pellucida 3 mediates ovarian damage and infertility after contraceptive vaccination in mice.
Volume: 35
Issue: 1
Pages: 77-85
Publication
First Author: Chamberlin ME
Year: 1989
Journal: Dev Biol
Title: Genomic organization of a sex specific gene: the primary sperm receptor of the mouse zona pellucida.
Volume: 131
Issue: 1
Pages: 207-14
Publication
First Author: Lou YH
Year: 1995
Journal: J Immunol
Title: Altered target organ. A mechanism of postrecovery resistance to murine autoimmune oophoritis.
Volume: 155
Issue: 7
Pages: 3667-73
Publication
First Author: Clydesdale G
Year: 2004
Journal: Reproduction
Title: Contraception in mice immunized with recombinant zona pellucida subunit 3 proteins correlates with Th2 responses and the levels of interleukin 4 expressed by CD4+ cells.
Volume: 128
Issue: 6
Pages: 737-45
Publication
First Author: Gahlay G
Year: 2010
Journal: Science
Title: Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein.
Volume: 329
Issue: 5988
Pages: 216-9
Publication
First Author: Coonrod SA
Year: 2004
Journal: Reprod Fertil Dev
Title: Oocyte proteomics: localisation of mouse zona pellucida protein 3 to the plasma membrane of ovulated mouse eggs.
Volume: 16
Issue: 1-2
Pages: 69-78
Publication
First Author: Roller RJ
Year: 1989
Journal: Development
Title: Gene expression during mammalian oogenesis and early embryogenesis: quantification of three messenger RNAs abundant in fully grown mouse oocytes.
Volume: 106
Issue: 2
Pages: 251-61
Publication
First Author: Tong ZB
Year: 1995
Journal: J Biol Chem
Title: Inhibition of zona pellucida gene expression by antisense oligonucleotides injected into mouse oocytes.
Volume: 270
Issue: 2
Pages: 849-53
Publication
First Author: Harris JD
Year: 1994
Journal: DNA Seq
Title: Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families.
Volume: 4
Issue: 6
Pages: 361-93
Publication
First Author: Youakim A
Year: 1994
Journal: J Cell Biol
Title: Overexpressing sperm surface beta 1,4-galactosyltransferase in transgenic mice affects multiple aspects of sperm-egg interactions.
Volume: 126
Issue: 6
Pages: 1573-83
Publication
First Author: Lu Q
Year: 1997
Journal: Development
Title: Sperm from beta 1,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly.
Volume: 124
Issue: 20
Pages: 4121-31
Publication
First Author: Epifano O
Year: 1995
Journal: Development
Title: Coordinate expression of the three zona pellucida genes during mouse oogenesis.
Volume: 121
Issue: 7
Pages: 1947-56
Publication
First Author: Prasad SV
Year: 2000
Journal: Cells Tissues Organs
Title: Structure and function of the proteins of the mammalian Zona pellucida.
Volume: 166
Issue: 2
Pages: 148-64
Publication
First Author: Soyal SM
Year: 2000
Journal: Development
Title: FIGalpha, a germ cell-specific transcription factor required for ovarian follicle formation.
Volume: 127
Issue: 21
Pages: 4645-54
Publication  
First Author: Naz RK
Year: 2005
Journal: Front Biosci
Title: Gene knockouts that cause female infertility: search for novel contraceptive targets.
Volume: 10
Pages: 2447-59
Allele
Name: transgene insertion 1, Gerald W Hart
Allele Type: Transgenic
Attribute String: Recombinase
Publication categories: ProxyCollection
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus musculus
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Kinloch RA
Year: 1989
Journal: Nucleic Acids Res
Title: Nucleotide sequence of the gene encoding zona pellucida glycoprotein ZP3--the mouse sperm receptor.
Volume: 17
Issue: 7
Pages: 2861-3
Publication
First Author: Wassarman PM
Year: 1997
Journal: Proc Biol Sci
Title: Mutant female mice carrying a single mZP3 allele produce eggs with a thin zona pellucida, but reproduce normally.
Volume: 264
Issue: 1380
Pages: 323-8
Publication
First Author: Wassarman PM
Year: 1998
Journal: Histol Histopathol
Title: Ovarian development in mice bearing homozygous or heterozygous null mutations in zona pellucida glycoprotein gene mZP3.
Volume: 13
Issue: 1
Pages: 293-300
Publication
First Author: Liu C
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice.
Volume: 93
Issue: 11
Pages: 5431-6
Publication
First Author: Qi H
Year: 1999
Journal: Dev Genet
Title: Secretion of zona pellucida glycoprotein mZP2 by growing oocytes from mZP3(+/+) and mZP3(-/-) mice.
Volume: 25
Issue: 2
Pages: 95-102
Publication
First Author: Ringuette MJ
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Oocyte-specific gene expression: molecular characterization of a cDNA coding for ZP-3, the sperm receptor of the mouse zona pellucida.
Volume: 83
Issue: 12
Pages: 4341-5
Publication
First Author: Schickler M
Year: 1992
Journal: Mol Cell Biol
Title: A mouse oocyte-specific protein that binds to a region of mZP3 promoter responsible for oocyte-specific mZP3 gene expression.
Volume: 12
Issue: 1
Pages: 120-7
Publication
First Author: Lira SA
Year: 1993
Journal: Mol Reprod Dev
Title: cis-acting DNA elements involved in oocyte-specific expression of mouse sperm receptor gene mZP3 are located close to the gene's transcription start site.
Volume: 36
Issue: 4
Pages: 494-9
Publication
First Author: Ward CR
Year: 1994
Journal: J Biol Chem
Title: Selective activation of Gi1 and Gi2 in mouse sperm by the zona pellucida, the egg's extracellular matrix.
Volume: 269
Issue: 18
Pages: 13254-8
Publication
First Author: Litscher ES
Year: 1995
Journal: Biochemistry
Title: Oligosaccharide constructs with defined structures that inhibit binding of mouse sperm to unfertilized eggs in vitro.
Volume: 34
Issue: 14
Pages: 4662-9
Publication
First Author: Litscher ES
Year: 1996
Journal: Biochemistry
Title: Characterization of mouse ZP3-derived glycopeptide, gp55, that exhibits sperm receptor and acrosome reaction-inducing activity in vitro.
Volume: 35
Issue: 13
Pages: 3980-5
Publication
First Author: Johnston DS
Year: 1998
Journal: J Biol Chem
Title: Murine sperm-zona binding, a fucosyl residue is required for a high affinity sperm-binding ligand. A second site on sperm binds a nonfucosylated, beta-galactosyl-capped oligosaccharide.
Volume: 273
Issue: 4
Pages: 1888-95
GXD Expression      
Probe: MGI:5637971
Assay Type: RT-PCR
Annotation Date: 2015-06-01
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Stage: TS28
Assay Id: MGI:5637985
Age: postnatal day 4
Detected: true
Specimen Num: 2