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Protein Coding Gene : Lin28a lin-28 homolog A

Primary Identifier  MGI:1890546 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  83557
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables RNA binding activity and translation initiation factor binding activity. Involved in several processes, including RNA metabolic process; cellular response to glucose stimulus; and positive regulation of intracellular signal transduction. Acts upstream of or within several processes, including miRNA metabolic process; negative regulation of glial cell differentiation; and regulation of gene expression. Located in nucleolus and rough endoplasmic reticulum. Is expressed in several structures, including early conceptus; embryo ectoderm; gonad; limb primordium; and tooth. Orthologous to human LIN28A (lin-28 homolog A).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased birth weight and postnatal lethality. In another report, mice homozygous for the same or an identical allele exhibit reduced premordial germ cells and fertility. [provided by MGI curators]
  • synonyms:
  • Lin28a,
  • lin-28 homolog A,
  • testis expressed gene 17,
  • Tex17,
  • Lin-28,
  • AL024421,
  • expressed sequence AL024421,
  • lin-28 homolog (C. elegans),
  • MGI:2140415,
  • Lin28

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

0 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For