| Primary Identifier | IPR044414 | Type | Domain |
| Short Name | PRDM2_PR-SET |
| description | This entry represents the PR/SET domain found in PR domain zinc finger protein 2 (PRDM2, also known as RIZ1). PRDM2 is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3 [, ].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes []. |
