| First Author | Chen D | Year | 2005 |
| Journal | Science | Volume | 310 |
| Issue | 5754 | Pages | 1641 |
| PubMed ID | 16339438 | Mgi Jnum | J:104203 |
| Mgi Id | MGI:3611511 | Doi | 10.1126/science.1118357 |
| Citation | Chen D, et al. (2005) Increase in activity during calorie restriction requires Sirt1. Science 310(5754):1641 |
| abstractText | Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice. |
