| First Author | Yin X | Year | 2018 |
| Journal | Biochem Biophys Res Commun | Volume | 495 |
| Issue | 1 | Pages | 672-678 |
| PubMed ID | 29129695 | Mgi Jnum | J:273422 |
| Mgi Id | MGI:6276790 | Doi | 10.1016/j.bbrc.2017.11.059 |
| Citation | Yin X, et al. (2018) Tetrahydroxystilbene glucoside modulates amyloid precursor protein processing via activation of AKT-GSK3beta pathway in cells and in APP/PS1 transgenic mice. Biochem Biophys Res Commun 495(1):672-678 |
| abstractText | Alternative splicing of amyloid precursor protein (APP) exon 7 generates the isoforms containing a Kunitz protease inhibitor (KPI) domain. APP-KPI levels in the brain are correlated with amyloid beta (Abeta) production. Here, we determined the effect of Tetrahydroxystilbene glucoside (TSG) on the AKT-GSK3beta pathway. We found GSK3beta increased APP-KPI inclusion level and interacted with the splicing factor ASF. TSG was intragastrically administered to 5-month-old APP/PS1 transgenic mice for 12 months. We found that the activated the AKT-GSK3beta signaling pathway suppressed APP-KPI inclusion. Moreover, TSG treatment attenuated amyloid deposition in APP/PS1 mice. This study demonstrates the neuroprotective effect of TSG on APP expression, suggesting that TSG may be beneficial for AD prevention and treatment. |
