| First Author | Gao R | Year | 2024 |
| Journal | Dev Cell | Volume | 59 |
| Issue | 9 | Pages | 1146-1158.e6 |
| PubMed ID | 38574734 | Mgi Jnum | J:347803 |
| Mgi Id | MGI:7627941 | Doi | 10.1016/j.devcel.2024.03.015 |
| Citation | Gao R, et al. (2024) Defining a TFAP2C-centered transcription factor network during murine peri-implantation. Dev Cell 59(9):1146-1158.e6 |
| abstractText | Transcription factors (TFs) play important roles in early embryonic development, but factors regulating TF action, relationships in signaling cascade, genome-wide localizations, and impacts on cell fate transitions during this process have not been clearly elucidated. In this study, we used uliCUT&RUN-seq to delineate a TFAP2C-centered regulatory network, showing that it involves promoter-enhancer interactions and regulates TEAD4 and KLF5 function to mediate cell polarization. Notably, we found that maternal retinoic acid metabolism regulates TFAP2C expression and function by inducing the active demethylation of SINEs, indicating that the RARG-TFAP2C-TEAD4/KLF5 axis connects the maternal-to-zygotic transition to polarization. Moreover, we found that both genomic imprinting and SNP-transferred genetic information can influence TF positioning to regulate parental gene expressions in a sophisticated manner. In summary, we propose a ternary model of TF regulation in murine embryonic development with TFAP2C as the core element and metabolic, epigenetic, and genetic information as nodes connecting the pathways. |
