| Primary Identifier | MGI:96608 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 16410 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables integrin binding activity. Contributes to opsonin binding activity and protein kinase C binding activity. Involved in several processes, including ERK1 and ERK2 cascade; extrinsic apoptotic signaling pathway in absence of ligand; and positive regulation of osteoblast proliferation. Acts upstream of or within blood vessel development. Located in external side of plasma membrane. Part of integrin alphav-beta5 complex and integrin alphav-beta6 complex. Is expressed in several structures, including early conceptus; embryo mesenchyme; jaw; skeletal muscle; and ventricular layer. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and acute myeloid leukemia. Orthologous to human ITGAV (integrin subunit alpha V). PHENOTYPE: Homozygotes for a targeted null mutation exhibit placental defects, intracerebral and intestinal hemorrhages, and cleft palate, resulting in death occurring as early as midgestation and as late as shortly after birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
