| First Author | Cortés I | Year | 2012 |
| Journal | Proc Natl Acad Sci U S A | Volume | 109 |
| Issue | 28 | Pages | 11318-23 |
| PubMed ID | 22733740 | Mgi Jnum | J:186407 |
| Mgi Id | MGI:5432282 | Doi | 10.1073/pnas.1118138109 |
| Citation | Cortes I, et al. (2012) p85beta phosphoinositide 3-kinase subunit regulates tumor progression. Proc Natl Acad Sci U S A 109(28):11318-23 |
| abstractText | PIK3R2 encodes a ubiquitous regulatory subunit (p85beta) of PI3K, an enzyme that generates 3-polyphosphoinositides at the plasma membrane. PI3K activation triggers cell survival and migration. We found that p85beta expression is elevated in breast and colon carcinomas and that its increased expression correlates with PI3K pathway activation and tumor progression. p85beta expression induced moderate PIP(3) generation at the cell membrane and enhanced cell invasion. In accordance, genetic alteration of pik3r2 expression levels modulated tumor progression in vivo. Increased p85beta expression thus represents a cellular strategy in cancer progression. |
