| First Author | Kaltschmidt B | Year | 2006 |
| Journal | Mol Cell Biol | Volume | 26 |
| Issue | 8 | Pages | 2936-46 |
| PubMed ID | 16581769 | Mgi Jnum | J:107412 |
| Mgi Id | MGI:3621100 | Doi | 10.1128/MCB.26.8.2936-2946.2006 |
| Citation | Kaltschmidt B, et al. (2006) NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling. Mol Cell Biol 26(8):2936-46 |
| abstractText | Synaptic activity-dependent de novo gene transcription is crucial for long-lasting neuronal plasticity and long-term memory. In a forebrain neuronal conditional NF-kappaB-deficient mouse model, we demonstrate here that the transcription factor NF-kappaB regulates spatial memory formation, synaptic transmission, and plasticity. Gene profiling experiments and analysis of regulatory regions identified the alpha catalytic subunit of protein kinase A (PKA), an essential memory regulator, as a new NF-kappaB target gene. Consequently, NF-kappaB inhibition led to a decrease in forskolin-induced CREB phosphorylation. Collectively, these results disclose a novel hierarchical transcriptional network involving NF-kappaB, PKA, and CREB that leads to concerted nuclear transduction of synaptic signals in neurons, accounting for the critical function of NF-kappaB in learning and memory. |
