| First Author | Wilson CM | Year | 1978 |
| Journal | Proc Natl Acad Sci U S A | Volume | 75 |
| Issue | 11 | Pages | 5623-6 |
| PubMed ID | 281712 | Mgi Jnum | J:6070 |
| Mgi Id | MGI:54547 | Doi | 10.1073/pnas.75.11.5623 |
| Citation | Wilson CM, et al. (1978) Location on chromosome 1 of Rnr, a gene that regulates renin in the submaxillary gland of the mouse. Proc Natl Acad Sci U S A 75(11):5623-6 |
| abstractText | Renin activity (EC 3.4.99.19) was measured in submaxillary gland extracts from four sets of recombinant inbred mouse strains. Recombination between Rnr, a gene that mediates the susceptibility of submaxillary gland renin to induction by androgen, and Dip-1, a chromosome 1 marker, was found in only 1 of 51 recombinant inbred strains, indicating that the two genes are closely linked on chromosome 1. Renin activity in androgen-treated female mice of all recombinant inbred strains resembled that of one or the other progenitor strains, as expected if a single gene is responsible. Documentation that a single gene can have major effects on renin in the submaxillary gland of the mouse implies that single gene differences might explain known variations in renin in other species. |
