| First Author | Terem A | Year | 2020 |
| Journal | Curr Biol | Volume | 30 |
| Issue | 18 | Pages | 3522-3532.e6 |
| PubMed ID | 32707061 | Mgi Jnum | J:328630 |
| Mgi Id | MGI:6820680 | Doi | 10.1016/j.cub.2020.06.064 |
| Citation | Terem A, et al. (2020) Claustral Neurons Projecting to Frontal Cortex Mediate Contextual Association of Reward. Curr Biol 30(18):3522-3532.e6 |
| abstractText | The claustrum is a small nucleus, exhibiting vast reciprocal connectivity with cortical, subcortical, and midbrain regions. Recent studies, including ours, implicate the claustrum in salience detection and attention. In the current study, we develop an iterative functional investigation of the claustrum, guided by quantitative spatial transcriptional analysis. Using this approach, we identify a circuit involving dopamine-receptor expressing claustral neurons projecting to frontal cortex necessary for context association of reward. We describe the recruitment of claustral neurons by cocaine and their role in drug sensitization. In order to characterize the circuit within which these neurons are embedded, we apply chemo- and opto-genetic manipulation of increasingly specified claustral subpopulations. This strategy resolves the role of a defined network of claustrum neurons expressing dopamine D1 receptors and projecting to frontal cortex in the acquisition of cocaine conditioned-place preference and real-time optogenetic conditioned-place preference. In sum, our results suggest a role for a claustrum-to-frontal cortex circuit in the attribution of incentive salience, allocating attention to reward-related contextual cues. |
