| First Author | Mak TW | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 8 | Pages | 765-72 |
| PubMed ID | 12833154 | Mgi Jnum | J:84668 |
| Mgi Id | MGI:2668806 | Doi | 10.1038/ni947 |
| Citation | Mak TW, et al. (2003) Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat Immunol 4(8):765-72 |
| abstractText | Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and temporal dynamics underlying its in vivo effects are poorly defined. Here we have shown that Icosl(-/-) and Icos(-/-) mice had similar phenotypes and that ICOS-ICOSL costimulation modulated the early but not late phases of IgG1 affinity maturation. Exploiting the adoptive transfer of T or B cells from primed Icosl(-/-) mice, we provided genetic evidence that costimulation through ICOSL was essential for primary but not secondary helper T cell responses and for the control of both T and B cell activities, resulting in T cell-dependent IgG1 production. |
