Primary Identifier | IPR033833 | Type | Domain |
Short Name | Alpha2AP_serpin_dom |
description | Alpha2-antiplasmin (alpha2AP; plasmin inhibitor; MEROPS identifier I04.023) is the primary inhibitor of plasmin, a proteinase that digests fibrin, the main component of blood clots. Alpha2-antiplasmin forms an inactive 1:1 stoichiometric complex with plasmin. It also rapidly crosslinks to fibrin during blood clotting by activated coagulation factor XIII, and as a consequence fibrin becomes more resistant to fibrinolysis. Therefore alpha2AP is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin [, ]. Alpha2-antiplasmin corresponds to clade F2 of the serpin superfamily (MEROPS family I4) [, ]. |