| First Author | Laureys G | Year | 1988 |
| Journal | Genomics | Volume | 3 |
| Issue | 3 | Pages | 224-9 |
| PubMed ID | 2852162 | Mgi Jnum | J:9629 |
| Mgi Id | MGI:58086 | Doi | 10.1016/0888-7543(88)90083-3 |
| Citation | Laureys G, et al. (1988) Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse. Genomics 3(3):224-9 |
| abstractText | The gene for insulin-like growth factor II (IGF-II) receptor (IGF2R) that has recently been found, by DNA sequencing, to be identical to the cation-independent mannose 6-phosphate receptor (CIM6PR) has been mapped in the human and murine species. Cloned cDNAs for human and rat IGF-II receptors were used to probe Southern blots of somatic cell hybrid DNA and for in situ chromosomal hybridization. The genes are located in a region of other conserved syntenic genes on the long arm of human chromosome 6, region 6q25----q27, and mouse chromosome 17, region A-C. The CIM6PR/IGF2R locus in man is asyntenic with the genes encoding IGF-II (IGF2), the IGF-I receptor (IGF1R), and the cation-dependent mannose 6-phosphate receptor (CDM6PR). |
