| Primary Identifier | MGI:99479 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12426 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and type B gastrin/cholecystokinin receptor binding activity. Acts upstream of or within several processes, including digestive tract development; gastric acid secretion; and pH reduction. Located in membrane. Is expressed in several structures, including central nervous system; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in pancreatic cancer and panic disorder. Orthologous to human CCKBR (cholecystokinin B receptor). PHENOTYPE: Nullizygous mice show gastic mucoca defects, high gastic pH and hypergastrenemia. Homozygotes for a null allele also exhibit higher energy intake and expenditure, less susceptibility to endotoxin shock, altered pain and mechanical sensitivity, and behavioral changes to isolation and addictive drugs. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
