| First Author | Cao D | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 1 | Pages | 364-76 |
| PubMed ID | 15601857 | Mgi Jnum | J:95385 |
| Mgi Id | MGI:3525929 | Doi | 10.1128/MCB.25.1.364-376.2005 |
| Citation | Cao D, et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol 25(1):364-76 |
| abstractText | Differentiation of smooth muscle cells is accompanied by the transcriptional activation of an array of muscle-specific genes controlled by serum response factor (SRF). Myocardin is a cardiac and smooth muscle-specific expressed transcriptional coactivator of SRF and is sufficient and necessary for smooth muscle gene expression. Here, we show that myocardin induces the acetylation of nucleosomal histones surrounding SRF-binding sites in the control regions of smooth muscle genes. The promyogenic activity of myocardin is enhanced by p300, a histone acetyltransferase that associates with the transcription activation domain of myocardin. Conversely, class II histone deacetylases interact with a domain of myocardin distinct from the p300-binding domain and suppress smooth muscle gene activation by myocardin. These findings point to myocardin as a nexus for positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation. |
