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Publication : Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration.

First Author  Horvath DH Year  1996
Journal  Gene Volume  171
Issue  2 Pages  305-6
PubMed ID  8666294 Mgi Jnum  J:33634
Mgi Id  MGI:81112 Doi  10.1016/0378-1119(96)00033-9
Citation  Horvath DH, et al. (1996) Probable exclusion of the cortexin-encoding gene as a candidate for mouse neurological mutants: nervous, tottering and motor neuron degeneration. Gene 171(2):305-6
abstractText  We have tested the gene encoding cortexin, Ctxn, which maps to chromosome 8, as a candidate for the mouse neurological mutants: nervous (nr), tottering (tg) plus tottering-leaner (tg(la)), and motor neuron degeneration (mnd) by Northern blot analysis of brain poly(A)(+) RNA and direct polymerase chain reaction (PCR) sequencing. No difference from wild-type was seen in any of these mutants. Based upon these observations, we conclude that Ctxn is not involved in the genetic defects found in nr, tg or mnd mice.
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