| First Author | Mathur R | Year | 2012 |
| Journal | Cell | Volume | 151 |
| Issue | 3 | Pages | 590-602 |
| PubMed ID | 23101627 | Mgi Jnum | J:189211 |
| Mgi Id | MGI:5444760 | Doi | 10.1016/j.cell.2012.08.042 |
| Citation | Mathur R, et al. (2012) A mouse model of salmonella typhi infection. Cell 151(3):590-602 |
| abstractText | Salmonella spp. are gram-negative flagellated bacteria that can cause food- and waterborne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S. Typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S. Typhimurium, S. Typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice, but not in humans, and remarkably, we find that tlr11(-/-) mice are efficiently infected with orally administered S. Typhi. We also find that tlr11(-/-) mice can be immunized against S. Typhi. Therefore, tlr11(-/-) mice represent a small-animal model for the study of the immune response to S. Typhi and for the development of vaccines against this important human pathogen. |
