| Primary Identifier | MGI:108088 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 14388 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables signaling adaptor activity. Involved in epidermal growth factor receptor signaling pathway and positive regulation of cell migration by vascular endothelial growth factor signaling pathway. Acts upstream of or within several processes, including cell surface receptor signaling pathway; labyrinthine layer development; and positive regulation of MAPK cascade. Located in cytoplasm. Is active in cell cortex. Is expressed in several structures, including brain; gonad; gut; hemolymphoid system gland; and primordial germ cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 26. Orthologous to human GAB1 (GRB2 associated binding protein 1). PHENOTYPE: Homozygotes for targeted null mutations exhibit developmental defects in the placenta, heart, eye, muscle, and skin, and die between embryonic day 13.5 and 18.5. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
