| First Author | McKay LM | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 2 | Pages | 302-8 |
| PubMed ID | 1427847 | Mgi Jnum | J:2639 |
| Mgi Id | MGI:51161 | Doi | 10.1016/s0888-7543(05)80220-4 |
| Citation | McKay LM, et al. (1992) Mapping human X-linked genes in the phalangerid marsupial Trichosurus vulpecula. Genomics 14(2):302-8 |
| abstractText | We mapped 15 human X-chromosome markers in the common brush-tailed possum, Trichosurus vulpecula (Kerr), which represents the Australian marsupial family Phalangeridae. In situ hybridization was used to localize highly conserved human X-linked genes to chromosomes of T. vulpecula diploid lines. Ten genes located on the long arm of the human X (human Xq genes) all mapped to the possum X chromosome. However, all five genes located on the short arm of the human X (human Xp genes) mapped to autosomes. These findings confirm our previous work, which showed that the X chromosome in macropodid and dasyurid marsupials bears all the human Xq genes but none of the human Xp genes studied. This suggests that the marsupial X is highly conserved, but its gene content reflects that of only part of the eutherian X, a result consistent with our hypothesis that an autosomal region was added to the X early in eutherian divergence. |
