| Primary Identifier | MGI:1913332 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 66082 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables acylglycerol lipase activity and phospholipase activity. Involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Acts upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Located in late endosome membrane; lysosomal membrane; and mitochondrion. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic membrane. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol lipase). PHENOTYPE: Homozygous null mice show increased glucose-stimulated insulin secretion from islets which exhibit elevated monoacylglycerol content in response to glucose. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
