| Primary Identifier | MGI:108448 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 11600 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables signaling receptor binding activity. Acts upstream of or within several processes, including blood vessel development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to be located in membrane raft; microvillus; and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including brain; cardiovascular system; liver; metanephros; and respiratory system. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; hereditary angioedema; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1). PHENOTYPE: Mice homozygous for disruptions in this gene display embryonic lethality by E12.5 and deficits in vascular development such as a reduction in vascular branching. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
