| First Author | Speirs K | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 2 | Pages | 752-6 |
| PubMed ID | 14707043 | Mgi Jnum | J:87356 |
| Mgi Id | MGI:2686746 | Doi | 10.4049/jimmunol.172.2.752 |
| Citation | Speirs K, et al. (2004) Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function. J Immunol 172(2):752-6 |
| abstractText | RelB, a member of the NF-kappaB family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-kappaB2/p100. The studies presented in this report show that DCs lacking NF-kappaB2 have dramatically enhanced RelB activity, associated with increased MHC class II and costimulatory molecule expression and an enhanced ability to induce CD4(+) T cell responses. These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses. |
